A pilot study to determine vitiligo target size using a computer-based image analysis program

Sheth, Vaneeta M.; Rithe, Rahul; Pandya, Amit G.; Chandrakasan, Anantha P.

doi:10.1016/j.jaad.2015.04.035

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…The image analysis also detected improvement with therapeutic intervention and was able to measure marginal and perifollicular repigmentation which is in agreement with other studies. 14,15…”

Section: Discussionmentioning

confidence: 99%

<p>Effect of Topical 5-Fluorouracil Alone versus Its Combination with Erbium:YAG (2940 nm) Laser in Treatment of Vitiligo</p>

Abdelwahab

Salah

Samy

et al. 2020

CCID

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To compare the efficacy of topical 5-FU as monotherapy to combined therapy of topical 5-FU and Er:YAG (2940 nm) laser in the treatment of non-segmental vitiligo (NSV). Methods: This is a prospective randomized comparative study. Thirty patients diagnosed with NSV were recruited from the dermatology outpatient clinics of the Medical Research Centre of Excellence, the National Research Centre and the National Institute of Laser Enhanced Sciences. Our study group was divided into two subgroups, Group 1 was subjected to ablative Er:YAG and 5-FU cream and Group 2 applied topical 5-FU cream. Three treatment sessions were repeated every 4 to 6 weeks and patients were followed up to 9 months. Repigmentation was assessed by digital photography and subsequent computer based image analysis. Results: Repigmentation of Group 1 patients ranged from 0 to 70% (mean 12±7%) whilst in Group 2 this ranged from 0 to 5% (mean 1.4±0.8%). In Group 1 repigmentation was mild in 22/30 (73.3%) and moderate to severe in 3/30 (10%) starting after 3 months and persisted or increased during the period of follow up to 9 months. Groups 1 and 2 were subdivided into A and B, vitiligo involving non-resistant and resistant areas respectively. Group 1A showed more repigmentation (mean 13.8±8.5%) than Group 1B (mean 9.8±4.5%) and Group 2A showed more repigmentation (mean 1.5±1%) than Group 2B (mean 1.3±0.5%). Conclusion: The combination of Er:YAG with 5-FU is safe and effective in treating and improving outcome in vitiligo especially of non-resistant areas. Computer based image analysis of vitiliginous lesions and assessing post-therapy response is an easy, quick, and reliable method.

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Section: Discussionmentioning

confidence: 99%

<p>Effect of Topical 5-Fluorouracil Alone versus Its Combination with Erbium:YAG (2940 nm) Laser in Treatment of Vitiligo</p>

Abdelwahab

Salah

Samy

et al. 2020

CCID

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“…An objective assessment method of therapeutic efficacy is necessary in vitiligo management, in addition to standard photographing protocol 241 and helpful instruments (Wood's lamp, dermoscopy, and in vivo confocal microscopy). To meet the clinical needs, several studies employed imaging analysis to evaluate the changes of the depigmentation area, but restricted by factors like large depigmentation, curved body surface and complex repigmentation patterns 242–245 . A recent publication introduced a delicate method to generate VASI automatically, through superpixel‐generated computerized digital image analysis of clinical photographs with ImageJ 246 .…”

Section: Adaptive Immune Activationmentioning

confidence: 99%

Mechanisms of melanocyte death in vitiligo

Chen

2020

Medicinal Research Reviews

126

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Vitiligo is an autoimmune depigment disease results from extensive melanocytes destruction. The destruction of melanocyte is thought to be of multifactorial causation. Genome‐wide associated studies have identified single‐nucleotide polymorphisms in a panel of susceptible loci as risk factors in melanocyte death. But vitiligo onset can't be solely attributed to a susceptive genetic background. Oxidative stress triggered by elevated levels of reactive oxygen species accounts for melanocytic molecular and organelle dysfunction, a minority of melanocyte demise, and melanocyte‐specific antigens exposure. Of note, the self‐responsive immune function directly contributes to the bulk of melanocyte deaths in vitiligo. The aberrantly heightened innate immunity, type‐1‐skewed T helper, and incompetent regulatory T cells tip the balance toward autoreaction and CD8+ cytotoxic T lymphocytes finally execute the killing of melanocytes, possibly alarmed by resident memory T cells. In addition to the well‐established apoptosis and necrosis, we discuss several death modalities like oxeiptosis, ferroptosis, and necroptosis that are probably employed in melanocyte destruction. This review focuses on the various mechanisms of melanocytic death in vitiligo pathogenesis to demonstrate a panorama of that. We hope to provide new insights into vitiligo pathogenesis and treatment strategies by the review.

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“…Recent publications on the objective measurement of vitiligo have included an automated digital image analysis system that is able to transform and align identified lesions from follow‐up images with those in the initial image. This allows the percentage change in area over time, or ‘automated fill factor’, which represents the percentage of repigmentation to be determined (Sheth et al., ). The emerging technique of 3D imaging and analysis to quantify the affected body surface area of subjects with vitiligo has also been recently described (Kohli et al., ).…”

Section: Section Imentioning

confidence: 99%

Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference

Gan

Eleftheriadou

Esmat

et al. 2017

Pigment Cell Melanoma Res

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The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr. Treatment is defined as successful if repigmentation exceeds 80% and at least 80% of the gained repigmentation is maintained for over 6 months. No agreement was found on the best outcome measure for assessing target or global repigmentation, therefore highlighting the limitations of e-surveys in addressing clinical measurements. Until there is a clear consensus, existing tools should be selected according to the specific needs of each study. A workshop will be conducted to address the remaining issues so as to achieve a consensus.

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A pilot study to determine vitiligo target size using a computer-based image analysis program

Cited by 8 publications

References 4 publications

<p>Effect of Topical 5-Fluorouracil Alone versus Its Combination with Erbium:YAG (2940 nm) Laser in Treatment of Vitiligo</p>

<p>Effect of Topical 5-Fluorouracil Alone versus Its Combination with Erbium:YAG (2940 nm) Laser in Treatment of Vitiligo</p>

Mechanisms of melanocyte death in vitiligo

Repigmentation in vitiligo: position paper of the Vitiligo Global Issues Consensus Conference

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