A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population

Gounden, Verena; Warasally, Mohamed Zain; Magwai, Thabo; Naidoo, Rajen N.; Chuturgoon, Anil A.

doi:10.1016/j.reprotox.2021.01.004

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…In a study involving various populations, the lowest levels of BPA were found in pregnant women from South Africa and the United States of America. The urinary concentrations of BPA during late pregnancy were found to be 1.16 and 0.73 ng/mL, respectively, whereas those of other bisphenols were similar to those observed in other population cohorts [ 65 , 66 ]. A study from South Korea reported the presence of BPA at a concentration of 0.53 ng/g in the placenta, indicating that it can be transferred from the mother to the fetus through the placental barrier [ 62 ].…”

Section: Contamination Status Of Bisphenolssupporting

confidence: 79%

“…The detection rates and concentrations of BPS in serum samples from male infants in the Chinese and South Korean studies were 5.33% (0.32 ng/mL) and 16.00% (0.28 ng/mL), respectively, which were higher than those observed in serum samples from female infants in both studies [ 78 ]. However, in a study from South Africa, the concentrations of BPA in umbilical cord blood samples from 60 male and female infants were 0.53 and 1.09 ng/mL, respectively, which were different from those observed in Chinese infants [ 65 ].…”

Section: Contamination Status Of Bisphenolsmentioning

confidence: 90%

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Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their endocrine-disrupting effects on female reproductive health. To provide a basis for future research on environmental interference and reproductive health, we reviewed relevant studies on the exposure patterns and levels of bisphenols in environmental matrices and humans (including susceptible populations such as pregnant women and children). In addition, we focused on in vivo, in vitro, and epidemiological studies evaluating the effects of bisphenols on the female reproductive system (the uterus, ovaries, fallopian tubes, and vagina). The results indicate that bisphenols cause structural and functional damage to the female reproductive system by interfering with hormones; activating receptors; inducing oxidative stress, DNA damage, and carcinogenesis; and triggering epigenetic changes, with the damaging effects being intergenerational. Epidemiological studies support the association between bisphenols and diseases such as cancer of the female reproductive system, reproductive dysfunction, and miscarriage, which may negatively affect the establishment and maintenance of pregnancy. Altogether, this review provides a reference for assessing the adverse effects of bisphenols on female reproductive health.

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Section: Contamination Status Of Bisphenolssupporting

confidence: 79%

Section: Contamination Status Of Bisphenolsmentioning

confidence: 90%

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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“…The maternal BPA treatment of 0.5 mg/kg/day produced umbilical arterial levels of ~2.6 ng/mL of free BPA on day 90 of fetal life [ 62 ]. These levels are within the range of BPA found in cord blood samples (range of 0.53–4.75 ng/mL) [ 63 , 137 , 138 , 139 , 140 ] from human cohort studies and are relevant to environmental exposure levels. BPA is ubiquitously present in the environment, air, water, soil, animal feed, wildlife, and humans [ 141 , 142 , 143 ].…”

Section: Discussionmentioning

confidence: 66%

Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Motta,

Thangaraj,

Padmanabhan

2023

Toxics

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Prenatal exposure to endocrine disruptors such as bisphenol A (BPA) plays a critical role in the developmental programming of liver dysfunction that is characteristic of nonalcoholic fatty liver disease (NAFLD). Circadian and aging processes have been implicated in the pathogenesis of NAFLD. We hypothesized that the prenatal BPA-induced fatty-liver phenotype of female sheep is associated with premature hepatic senescence and disruption in circadian clock genes. The expression of circadian rhythm and aging-associated genes, along with other markers of senescence such as telomere length, mitochondrial DNA copy number, and lipofuscin accumulation, were evaluated in the liver tissue of control and prenatal BPA groups. Prenatal BPA exposure significantly elevated the expression of aging-associated genes GLB1 and CISD2 and induced large magnitude differences in the expression of other aging genes—APOE, HGF, KLOTHO, and the clock genes PER2 and CLOCK—in the liver; the other senescence markers remained unaffected. Prenatal BPA-programmed aging-related transcriptional changes in the liver may contribute to pathological changes in liver function, elucidating the involvement of aging genes in the pathogenesis of liver steatosis.

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“…7 These include effects such as preterm birth and low birthweight. 14 Because these adverse birth outcomes are likely to impact on lung growth, there is a strong case for exploring antenatal exposure. However, immunological effects associated with exposure may occur both antenatally and postnatally, giving rise to asthma and allergic responses affecting lung health.…”

mentioning

confidence: 99%

“…Much of the research has focused on antenatal exposures, particularly because of the reproductive effects in pregnant women and newborns 7 . These include effects such as preterm birth and low birthweight 14 . Because these adverse birth outcomes are likely to impact on lung growth, there is a strong case for exploring antenatal exposure.…”

mentioning

confidence: 99%

Environmental plastics and lung health: Increasing evidence for concern

Naidoo

2022

Respirology

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A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population

Cited by 13 publications

References 34 publications

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Environmental plastics and lung health: Increasing evidence for concern

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