A pilot study on the use of silicone oil–RMN3 as heavier-than-water endotamponade agent

Rizzo, Stanislao; Genovesi-Ebert, Federica; Belting, Claudia; Vento, Andrea; Cresti, Federica

doi:10.1007/s00417-005-0015-6

Cited by 42 publications

(97 citation statements)

References 11 publications

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“…The BCVA improved in 71.4% of the patients, and retinal reattachment was achieved in 90.5% of the cases. This compared favorably with recent reports on the management of PVR (19)(20)(21). TA is a water-insoluble steroid that inhibits various postoperative inflammatory reactions, and TA granules have been shown to be safe for administration to the retina (14,22).…”

Section: Discussionsupporting

confidence: 65%

Long-Term Clinical Outcomes and Therapeutic Benefits of Triamcinolone-Assisted Pars Plana Vitrectomy for Proliferative Vitreoretinopathy: A Case Study

Ueno

Enaida

Hata

et al. 2007

European Journal of Ophthalmology

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Purpose. To investigate intraoperative visibility and long-term clinical outcome following triamcinolone acetonide (TA)-assisted pars plana vitrectomy (PPV) for proliferative vitreoretinopathy (PVR). Methods. A retrospective interventional noncomparative clinical study was carried out on 21 eyes from 21 patients with more than grade C2 PVR, all of whom underwent TA-assisted PPV. Two of the specimens were observed with an electron microscope. After treatment, outcome measures, including changes in best-corrected visual acuity (BCVA), intraocular pressure (IOP) elevation, corneal pathology, and occurrence of endophthalmitis, were recorded. Patient follow-up time was >36 months (mean ± standard deviation = 47.3 ± 6.7 months). Results. TA improved the intraoperative visualization of the epiretinal membrane (ERM), allowing it to be easily removed together with the partially internal limiting membrane (ILM) using microforceps. The excised tissue consisted of proliferative cells and an extracellular matrix underlying the ILM. After the operation, 71.4% of the eyes had improved BCVA. Three of the eyes showed sustained IOP elevation (14.3%); two of these cases were controlled by the administration of eyedrops, while the third required filtering surgery. In two cases, an absorption delay of the TA granule on the retinal surface was observed. One eye developed corneal stromal opacity. No other severe complications occurred during the observation period. Conclusions. TA-assisted PPV offers improved visualization during the surgical management of PVR, and allows surgeons to excise the ERM safely and effectively without the risk of serious complications.

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Section: Discussionsupporting

confidence: 65%

Long-Term Clinical Outcomes and Therapeutic Benefits of Triamcinolone-Assisted Pars Plana Vitrectomy for Proliferative Vitreoretinopathy: A Case Study

Ueno

Enaida

Hata

et al. 2007

European Journal of Ophthalmology

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“…This cloudiness is sufficient to interfere with vision and to impair fundal view. 32 Double filling has been tried with fluorinated silicone and conventional silicone. 47 When redetachment occurred, it occupied a 'new space horizontally between the bubbles and expanding in a triangular shape nasally to the optic disk and temporally to the macula'.…”

Section: Double Filling With F6h8 and Silicone Oilmentioning

confidence: 99%

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

116

125

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Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

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“…The intraocular inflammatory signs completely resolved following removal of the high-density silicone oil. In contrast, Rizzo et al 4 used Oxane Hd heavy silicone oil in 28 patients who were operated on for recurrent retinal detachment with proliferative vitreoretinopathy (stage ≥C2) after vitreoretinal surgery, penetrating trauma and combined rhegmatogenous and choroidal detachment. No patient showed intraocular inflammation with Oxane Hd in situ.…”

Section: >21mentioning

confidence: 99%

“…It is used especially in complex cases of rhegmatogenous retinal detachment if the condition is complicated by proliferative vitreoretinopathy and giant retinal tears [1][2][3] . In cases where the proliferative vitreoretinopathy and retinal breaks are found in the lower periphery of the retina, the use of heavy silicone oil is also considered 4,5 . It may be indicated too, in patients with proliferative diabetic retinopathy for conditions connected to repeated intravitreal hemorrhage, tractional retinal detachment, traction-rhegmatogenous retinal detachment and tractional retinal detachment with neovascular glaucoma 6,7 .…”

Section: Introductionmentioning

confidence: 99%