A pilot study on the use of outpatient fractionated ifosfamide, carboplatin and etoposide (ICE) and pegfilgrastim as a salvage and mobilizing regimen for relapsed and refractory non-Hodgkin's and Hodgkin's lymphoma

George, Biju; Benson, Warwick; Hertzberg, Mark

doi:10.1038/bmt.2011.197

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…13 The outpatient fractionated ICE treatment provides a practical and better acceptable alternative for such patients. 11 , 14 The overall response rate (ORR) (48.3%) to this regimen in our cohort is in the range of other previously described conventional salvage chemotherapy regimens (range 45–89%). 15–17,21 Of note, a significant number of the patients in our study had high risk features which included primary refractory (62.9%), advanced stages (87.7%) and extranodal disease (38.2%).…”

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confidence: 58%

Outpatient fractionated ICE protocol in relapsed/refractory lymphomas: Efficacy and safety

Dada

Abdelghani

Boubakra

et al. 2021

J Oncol Pharm Pract

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Methods In this retrospective trial, we analyzed data of patients with relapsed/refractory lymphoma who received outpatient fractionated ICE between 2011-2017 at a tertiary care center. The three weekly ICE protocol consisted of: ifosfamide 1500 mg/m2 infused over 2 h on days 1–3, carboplatin (5 AUC) on day 1, and etoposide 100 mg/m2 on days 1–3. Rituximab 375 mg/m2 was given to patients with CD20 positive B cell Non-Hodgkin lymphoma. Results Total of 89 patients were included in this research project. Majority of patients had Hodgkin lymphoma (64%). Mean number of ICE cycles received was 2.5. Complete remission and partial remission rates for primary refractory (62.9%) and non-primary refractory (36.4%) disease were 10.5% and 26.3% versus 41.9% and 29.0% respectively. Event free survival rate was 14.5 months (95% CI 7.7–28.0) and overall survival rate 88.7 months (95% CI 48.1–NR). Grade 3 hematological toxicities were documented in 19.1% of patients with 10.1% experiencing neutropenia and 9% thrombocytopenia. 5.6% had febrile neutropenia. Conclusions Our study included, to our knowledge, the largest number of patients treated with outpatient fractionated ICE. Results demonstrated that this regimen might be a reasonable replacement for classic ICE regimen in many patients with lymphoma. It has a favorable safety profile. However, patients with primary refractory lymphomas need more effective regimens.

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