A Pilot Study on Human Circulating System Indicated That Regenerating Islet-Derived Protein 3 Gamma (REG3A) is a Potential Prognostic Biomarker for Sepsis

Ding, Xian Fei; Liu, Shuxiong; Zhu, Shouchao; Zhou, Bing; Ma, Hui

doi:10.1016/j.amjcard.2022.11.036

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Reg3γ is abundant in the intestine under normal conditions, where it serves as an antimicrobial peptide that maintains the distance between the gut bacteria and the host, prevents bacterial translocation and regulates intestinal inflammation 8,26,80 . Reg3γ was also found to be a diagnostic and prognostic biomarker for predicting host responses to systemic inflammation [81][82][83] . In addition to animal studies, accumulating results indicate the clinical relevance of Reg3γ and related signaling pathways to metabolic disorders (Fig.…”

Section: Future Perspectivesmentioning

confidence: 99%

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

Shin,

Bozadjieva-Kramer,

Seeley

2023

Exp Mol Med

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Regenerating family member gamma, Reg3γ (the mouse homolog of human REG3A), belonging to the antimicrobial peptides (AMPs), functions as a part of the host immune system to maintain spatial segregation between the gut bacteria and the host in the intestine via bactericidal activity. There is emerging evidence that gut manipulations such as bariatric surgery, dietary supplementation or drug treatment to produce metabolic benefits alter the gut microbiome. In addition to changes in a wide range of gut hormones, these gut manipulations also induce the expression of Reg3γ in the intestine. Studies over the past decades have revealed that Reg3γ not only plays a role in the gut lumen but can also contribute to host physiology through interaction with the gut microbiota. Herein, we discuss the current knowledge regarding the biology of Reg3γ, its role in various metabolic functions, and new opportunities for therapeutic strategies to treat metabolic disorders.

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Section: Future Perspectivesmentioning

confidence: 99%

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

Shin,

Bozadjieva-Kramer,

Seeley

2023

Exp Mol Med

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“…In addition, in ammation, tissue damage and the activation of immune cells, widely-spreading in microbial infections after HSCT, would be the major pathophysiology of aGVHD. Further, the levels of diagnostic markers, such as IL-6, soluble suppression of tumorigenicity-2 (sST2) and regenerating islet-derived protein 3α, which are secreted by damaged end organs, are also increased in transplant recipients who develop severe infection and pathological damage but do not develop to aGVHD [11][12][13][14][15]. Thus, it is still di cult to diagnose aGVHD in the early phase as the lack of speci c markers and clinical signs [10].…”

Section: Introductionmentioning

confidence: 99%

E-selectin combined with soluble CD44 as predictors of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

YANG,

WANG,

CHENG

et al. 2024

Preprint

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Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the mainly curable treatment options in children with high-risk malignancies, bone marrow failure diseases and inherited metabolic diseases. Acute graft-versus-host disease (aGVHD) accompanied with series of serious complications are the most severe obstacle of allo-HSCT because the early and accurate diagnostic markers and effective treatment are still lacked. Non-organ-specific injury induced activated endothelial cells and tissue integrity biomarkers may have higher specificity for the occurrence and development of aGVHD. Methods The blood from 52 pediatric patients who underwent allo-HSCT including 16 recipients with aGVHD and 36 recipients without aGVHD were collected to check the level of adhesion molecules. The vitro experiments, transwell experiments, and aGVHD mouse model are used to verify the effects of E-selectin in the occurrence and development of aGVHD. Results We found that E-selectin secreted by endothelial cells was remarkably increased while the level of soluble CD44, a widely distributed tissue structure molecule, was significantly decreased in aGVHD patients. The level of E-selectin was negatively correlated with the soluble CD44 and associated with the severity of the aGVHD. After that, the vitro experiments suggested the elevated E-selectin could recruit immune cells that result in a series of inflammatory response and tissue injury. The aGVHD mouse model revealed that the level of E-selectin in the intestine occurred aGVHD was obviously increased than that without aGVHD. The expression level of CD44 in organs was related to the incidence of organ aGVHD. More importantly, the area under the ROC curve (AUC) of E-selectin and CD44 can reach 0.85 indicating that these two parameters have strong prediction ability of aGVHD. Conclusions E-selectin and CD44 could play an important role in the occurrence and development of aGVHD. E-selectin combined with soluble CD44 could act as efficient biomarkers for the diagnosis of aGVHD.

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A Pilot Study on Human Circulating System Indicated That Regenerating Islet-Derived Protein 3 Gamma (REG3A) is a Potential Prognostic Biomarker for Sepsis

Cited by 2 publications

References 19 publications

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

Reg3γ: current understanding and future therapeutic opportunities in metabolic disease

E-selectin combined with soluble CD44 as predictors of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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