A Pilot Study on BMI, Serum Testosterone and Estradiol Levels in Allergic Male Patients

Lokaj-Berisha, Violeta; Gacaferri-Lumezi, Besa; Berisha, Naser; Gashi-Hoxha, Sanije

doi:10.3889/oamjms.2015.101

Cited by 8 publications

(8 citation statements)

References 27 publications

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“…8,10,11 In the only study reported in the literature to investigate ED and the testosterone levels in male patients with allergic, it was shown that the testosterone level was lower in patients with asthma compared with the healthy control group, but there were no significant differences between two groups. 29 Similarly, in the current study, we detected that the testosterone level was lower in asthma patients compared with the control group, and differences between groups were significantly. Although the testosterone level in asthmatic patients is lower than the control group, the concentration of testosterone in our asthmatics (Mean ± SD:…”

Section: Discussionsupporting

confidence: 75%

“…In a few studies, it was reported that testosterone may be low in respiratory diseases such as COPD 8,10,11 . In the only study reported in the literature to investigate ED and the testosterone levels in male patients with allergic, it was shown that the testosterone level was lower in patients with asthma compared with the healthy control group, but there were no significant differences between two groups 29 . Similarly, in the current study, we detected that the testosterone level was lower in asthma patients compared with the control group, and differences between groups were significantly.…”

Section: Discussionmentioning

confidence: 96%

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Evaluation of erectile dysfunction in patients with asthma

Kılıç

Aydın²,

Berber

et al. 2021

Int J Clin Pract

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Objectives The aim of the current study was to investigate Erectile dysfunction (ED) in asthma patients without comorbidity and the relationship between the level of asthma control and ED. Methods Forty male patients aged 24‐50 years with controlled‐to‐uncontrolled asthma and 20 healthy volunteers were included in this study. The International Index of Erectile Function Questionnaire (IIEF) for ED was used. Results Evaluation of the IIEF scores for ED showed that 23 (57.5%) of the asthma patients and 4 (20.0%) of the controls had various degrees of ED, and the difference was statistically significant. In total, 25% of asthma patients had mild ED, 22.5% moderate ED, and 10% severe ED. Severe, moderate and mild ED was more frequent in the asthma group. Of the 23 patients who had various degrees of ED, 13 were in the uncontrolled asthma group. While all asthma patients with severe ED were in the uncontrolled asthma group, of the 9 asthma patients with moderate ED, 6 were in the uncontrolled asthma group, 2 were in the partially controlled asthma group and one was in the controlled asthma group. Additionally, of the 10 asthma patients with mild ED, 3 were in the uncontrolled asthma group, 2 were in the partially controlled asthma group and 5 were in the controlled asthma group. Conclusion The current study showed that ED is frequent and more severe in asthma patients than controls with same age. A highly negative correlation was found between ED degree and asthma control severity.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Evaluation of erectile dysfunction in patients with asthma

Kılıç

Aydın²,

Berber

et al. 2021

Int J Clin Pract

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“…Although obesity has been associated with increased IgE responses and allergic symptoms, whether it predisposes to an increased food allergy risk remains to be tested. [48][49][50][51] To investigate whether HFD feeding confers an increased risk of food allergy, wild-type C57BL/6J mice were fed an HFD (45 kcal% fat, D12451i; Research Diets), a matching control diet (10 kcal% fat, D12450H; Research Diets), or an SCD (4.5 kcal% fat; Provimim Kliba SA) for 12 weeks before induction of experimental food allergy (Fig 1, A). After establishment of obesity in the HFD group (Fig 1, B-D, and see Fig E1 in this article's Online Repository at www.jacionline.…”

Section: High Dietary Fat Intake Potentiates Food-induced Allergic Rementioning

confidence: 99%

High dietary fat intake induces a microbiota signature that promotes food allergy

Hussain

Bonilla-Rosso

Chung

et al. 2019

Journal of Allergy and Clinical Immunology

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Background: Diet-induced obesity and food allergies increase in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested. Objective: We sought to test the role of high dietary fat intake, diet-induced obesity, and associated changes in gut microbial community structure on food allergy pathogenesis. Methods: Mice were fed a high-fat diet (HFD) for 12 weeks before food allergen sensitization on an atopic dermatitis-like skin lesion, followed by intragastric allergen challenge to induce experimental food allergy. Germ-free animals were colonized with a signature HFD or lean microbiota for 8 weeks before induction of food allergy. Food-induced allergic responses were quantified by using a clinical allergy score, serum IgE levels, serum mouse mast cell protease 1 concentrations, and type 2 cytokine responses. Accumulation of intestinal mast cells was examined by using flow cytometry and chloroacetate esterase

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“…Generally, testosterone has been considered to act as immunosuppressant, and earlier studies have found low testosterone levels in atopic diseases patients, including atopic dermatitis [ 24 ], asthma alone and asthma with allergic rhinitis [ 25 ]. These studies support low levels of testosterone may be associated with the presence of atopic diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between GnRH analogue use and atopic diseases in patients with prostate cancer: A population-based retrospective cohort study

Lin

Lee

et al. 2022

PLoS ONE

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Purpose Gonadotropin-releasing hormone (GnRH) analogues reduce testosterone levels to castration levels in patients with prostate cancer. However, the role of testosterone in atopic diseases has remained undefined. We aimed to investigate this role. Materials and methods This retrospective cohort study was conducted using the National Health Insurance Research Database (NHIRD). Patients with prostate cancer were categorized into two groups according to whether they received GnRH analogue treatment (study group I) or not (study group II), and men without prostate cancer and with no GnRH analogue use were defined to comprise the comparison group after their ages and index years were matched with group II. Cox proportional hazard models were used to assess the hazard ratio (HR) of atopic diseases. Results Group I, group II, and the comparison group comprised 663, 2,172, and 8,688 individuals, respectively. Group I had a significantly lower risk of atopic diseases (adjusted HR: 0.66, 95% CI, 0.49–0.89, p < 0.01) than did group II. A reduced risk of atopic diseases was found when GnRH analogues were prescribed for 2 months (adjusted HR 0.53, 95% CI, 0.29–0.97, p = 0.04) and 2–14 months (adjusted HR 0.66, 95% CI, 0.49–0.89, p = 0.007). No significant difference in the risk of atopic diseases between group II and the comparison group was observed. Conclusions A decreased risk of atopic diseases was observed in patients with prostate cancer treated with GnRH analogues. Further studies are warranted to verify the association between testosterone levels and atopic diseases.

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A Pilot Study on BMI, Serum Testosterone and Estradiol Levels in Allergic Male Patients

Cited by 8 publications

References 27 publications

Evaluation of erectile dysfunction in patients with asthma

Evaluation of erectile dysfunction in patients with asthma

High dietary fat intake induces a microbiota signature that promotes food allergy

Association between GnRH analogue use and atopic diseases in patients with prostate cancer: A population-based retrospective cohort study

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