A Pilot Study on Antiplaque Effects of Mastic Chewing Gum in the Oral Cavity

Takahashi, Keiso; Fukazawa, Munemoto; Motohira, Hitoshi; Ochiai, Kuniyasu; Nishikawa, Hirofumi; Miyata, Takashi

doi:10.1902/jop.2003.74.4.501

Cited by 70 publications

(46 citation statements)

References 17 publications

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“…41 Conversely, double-blind, randomized studies on 20 dental students were performed to determine whether gum mastic has any antiplaque activity. 44 The results showed that mastic chewing gum may be useful in reducing the bacterial growth in saliva and plaque formation on teeth. Finally, the results of the current study strongly suggest that gum mastic may have antiprostate cancer effect through its suppressive effect on the expression and function of the AR.…”

Section: Discussionmentioning

confidence: 99%

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Yuan

An-li

et al. 2006

Cancer

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Accumulating evidence suggests that the androgen receptor (AR) may play an important role in the development and progression of prostate cancer. To find new, useful compounds that effectively may attenuate the function of AR in prostate cancer cells, the authors investigated the effect of gum mastic, a natural resin, on AR activity. An androgen-responsive prostate cancer cell line LNCaP was used as a model for this study. Gene transfer, reverse transcriptase-polymerase chain reaction analysis, electrophoretic mobility shift assay, and Western blot analysis were used to test the effect of gum mastic on the expression and function of the AR. To demonstrate the inhibitory effect of gum mastic on the function of the AR, the expression of androgen-regulated genes, including prostate-specific antigen (PSA), human kallikrein 2 (hK2), and NKX3.1 were measured. In addition, transient transfection assays with the PSA promoter and the AR promoter also were used to test the effects of mastic. The results showed that gum mastic inhibited the expression of the AR at the transcriptional level, resulting in the down-regulation of both AR messenger RNA and protein levels. Therefore, the function of the AR was inhibited, as reflected by the reduced expression of NKX3.1 and PSA and by androgen-stimulated growth. Because gum mastic exhibited a strong in vitro potency to attenuate the expression and function of the AR, further investigation will be required to determine whether this naturally occurring substance has in vivo potency to inhibit prostate cancer development.

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Section: Discussionmentioning

confidence: 99%

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Yuan

An-li

et al. 2006

Cancer

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“…[5] Focusing on these treatment options which possess limited effectiveness in high-risk populations and in those with advanced periodontal disease, [6] and associated with adverse side-effects and antibiotic resistance, [7] people are opting for alternative therapeutic and preventative measures which are safe, effective, and free of side effects. [8] Increasing popularity of traditional medicine has led researchers to investigated the adjunctive methods that use nutrients and functional foods to maintain the health status of periodontal tissues; for example, extracts of plants, including mastic exudated from Pistacia lentiscus [9] and macrocarpals from Eucalyptus globulus, [10,11] have also been investigated for their effects on periodontal health, particularly because of their safety.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of curcumin (turmeric) against periopathogens - An in vitro evaluation

Bomdyal¹,

Shah²,

Doshi³

et al. 2017

JCRI

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“…Pistacia lentiscus mastic is a natural resin derived from the stem and leaves of the mastic tree, P. lentiscus Linn, native to Mediterranean areas (Takahashi et al 2003). Traditional healers used it for the relief of upper abdominal discomfort, stomachaches, dyspepsia and peptic ulcer (Koo et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Substantial evidence has also suggested that P. lentiscus mastic gum exhibits hepatoprotective, cardioprotective, anti-inflammatory and antioxidant properties (Giaginis and Theocharis 2011). Numerous studies showed that P. lentiscus mastic has impressive antibacterial and antimicrobial properties (Takahashi et al 2003). Balan et al (2007) suggested that P. lentiscus mastic gum might be developed into a chemotherapeutic agent for the treatment of human cancer colon and other cancers.…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil

Eldin

Badawy

2013

J Parasit Dis

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Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. Metronidazole is the drug of choice for T. vaginalis infections. The increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. Pistacia lentiscus mastic and Ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. The present study was carried out to investigate the in vitro effects of P. lentiscus mastic and O. basilicum oil on T. vaginalis trophozoites. The effects of different concentrations of P. lentiscus mastic (15, 10 and 5 mg/ml) and different concentrations of O. basilicum oil (30, 20 and 10 lg/ml) on multiplication of trophozoites at different time points (after 24, 48, 72 and 96 h) were determined, also morphological changes were reported by transmission electron microscopy (TEM). The results showed that both plants caused an inhibition of growth of T. vaginalis trophozoites. The minimal lethal concentration of P. lentiscus mastic was 15 mg/ml after 24 h incubation, 10 mg/ml after 48 h and 5 mg/ml after 96 h. The minimal lethal concentration of O. basilicum oil was 30 lg/ml after 24 h incubation, 20 lg/ml after 48 h and 10 lg/ml after 96 h. TEM study of trophozoites treated by P. lentiscus mastic or by O. basilicum oil showed considerable damage of the membrane system of the trophozoites, and extensive vacuolization of the cytoplasm. These results highly suggest that P. lentiscus mastic and O. basilicum oil may be promising phytotherapeutic agents for trichomoniasis treatment.

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A Pilot Study on Antiplaque Effects of Mastic Chewing Gum in the Oral Cavity

Abstract: These results suggest that mastic chewing gum is a useful antiplaque agent in reducing the bacterial growth in saliva and plaque formation on teeth.

Cited by 70 publications

References 17 publications

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Antibacterial activity of curcumin (turmeric) against periopathogens - An in vitro evaluation

In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil

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