A pilot study on acute inflammation and cancer: a new balance between IFN-γ and TGF-β in melanoma

Abstract

Recent data have redefined the concept of inflammation as a critical component of tumor progression. However, there has been little development on cases where inflammation on or near a wound and a tumor exist simultaneously. Therefore, this pilot study aims to observe the impact of a wound on a tumor, to build a new mouse tumor model with a manufactured surgical wound representing acute inflammation, and to evaluate the relationship between acute inflammation or wound healing and the process of tumor growth. We focus on the two phases that are present when acute inflammation influences tumor. In the early phase, inhibitory effects are present. The process that produces these effects is the functional reaction of IFN-γ secretions from a wound inflammation. In the latter phase, the inhibited tumor is made resistant to IFN-γ through the release of TGF-β to balance the inflammatory factor effect on the tumor cells. A pair of cytokines IFN-γ/ TGF-β established a new balance to protect the tumor from the interference effect of the inflammation. The tumor was made resistant to IFN-γ through the release of TGF-β to balance the inflammatory effect on the tumor cells. This balance mechanism that occurred in the tumor cells increased proliferation and invasion. In vitro and in vivo experiments have confirmed a new view of clinical surgery that will provide more detailed information on the evaluation of tumors after surgery. This study also provides a better understanding of the relationship between tumor and inflammation, as well as tumor cell attacks on inflammatory factors.

Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

“…A previous study showed that IFN-γ induced by surgical wounds suppresses tumor growth in a syngeneic mouse tumor model [33]. Similar to our results, the growth suppression effect was lost over time and rapid tumor regrowth occurred.…”

The use of nitric oxide releasing nanoparticles as a treatment againstAcinetobacter baumanniiin wound infections

“…In fact, the downregulation of TGFβ, which can antagonize IFNγ effects, suggests that the NO-np might modulate the impairment of Ab to disseminate within immune cells. 34 Furthermore, downregulation of the pro-inflammatory cytokine, IL-1β by the NO-np are consistent with the fact that this cytokine can be expressed in late-stage of wound healing and the wounds in our experiments were excised in the early to middle stages of this coordinated process. 35 Incidentally, high levels of IL-1β promote Ab replication within phagocytic cells.…”

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

“…IFN-γ does inhibit human A172 glioma cell transmigration [192]; A172 cells do express gBK (Ge, Hoa and Jadus, unpublished results). B16 melanoma [193] and thyroid cancer cells, likewise are inhibited by IFN-γ in in vitro invasion assays, too [194]. …”