A Pilot Study of the FRAIL Scale on Predicting Outcomes in Chinese Elderly People With Type 2 Diabetes

Liu, Ying; Zou, Yuan; Wang, Shuang; Li, Jun; Jing, Xiaofan; Yang, Mengxuan; Wang, Lingxiao; Cao, Li; Yang, Xue; Xu, Ling; Dong, Birong

doi:10.1016/j.jamda.2015.05.019

Cited by 78 publications

(64 citation statements)

References 41 publications

(28 reference statements)

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“…Patients reporting 3–5, 1–2, and 0 factors are classified as frail, pre-frail, and robust, respectively. In addition, FRAIL is an independent risk factor for predicting mortality and adverse outcomes in specific populations 83–85…”

Section: Frail Scalementioning

confidence: 99%

Frailty assessment in older adults with chronic obstructive respiratory diseases

Guan¹,

Huang²

2018

CIA

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The number of patients with chronic obstructive pulmonary disease (COPD) has been rising with continued exposure to environmental risk factors and aging of populations around the world. Frailty is a geriatric syndrome with a decline in physiological reserve and often coexists with chronic diseases such as COPD. Frailty is an independent risk factor for the development and progression of COPD, and COPD can lead to frailty; treating one might improve the other. Thus, there is an increasing interest in the assessment of frailty in patients with COPD. Furthermore, early identification and assessment of frailty in patients with COPD may affect the choice of intervention and improve its effectiveness. Based on the current literature, the intent of this review was to summarize and discuss frailty assessment tools used for COPD patients and the relevant clinical practices for predicting outcomes. We ascertain that using suitable frailty assessment tools could facilitate physicians to screen and stratify physically frail patients with COPD. Screening appropriately targeted population can achieve better intervention outcomes and pulmonary rehabilitation among frail COPD patients.

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Section: Frail Scalementioning

confidence: 99%

Frailty assessment in older adults with chronic obstructive respiratory diseases

Guan¹,

Huang²

2018

CIA

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“…Frailty is an established risk factor for cardiovascular disease incidence and death in patients with cardiovascular disease, whereas cardiovascular comorbidity is a risk for frailty . A recent report from China showed that frailty is a risk factor independent from other classic vascular risk factors for adverse health outcomes including death in older adults with type 2 DM …”

Section: Adverse Outcomes Associated With Sarcopenia/frailty In Oldermentioning

confidence: 99%

Sarcopenia and frailty in older patients with diabetes mellitus

Umegaki

2016

Geriatrics Gerontology Int

134

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Sarcopenia is defined as age-associated loss of muscle mass and function, and is frequently accompanied by diabetes mellitus (DM) in older adults. Some of the mechanisms of the development of sarcopenia including insulin resistance, chronic inflammation and mitochondrial dysfunction are also associated with the pathogenesis of DM. Sarcopenia provides the basis for frailty, which is a state that is highly vulnerable to stressors, and can lead to disability, dependency and mortality, and older DM patients are often in a state of frailty. Given the background of an increasing number of older DM patients, the screening and early detection of sarcopenia/frailty and appropriate intervention would be expected to improve the prognosis and quality of life in older patients.

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“…We defined frailty using a modified version of the FRAIL scale, a widely used frailty-assessing instrument proposed by the International Association of Nutrition and Aging. The applicability of the FRAIL scale in patients with diabetes has been demonstrated in different populations, including Asian and domestic ones 9 10. The original FRAIL scale was created based on responses to five self-reported items, namely: fatigue, resistance, ambulation, illness, and loss of body weight;11 the scoring results of the FRAIL scale have been extensively found to correlate with medical outcomes, including disability, healthcare utilization, costs, and overall survival 7 12.…”

Section: Methodsmentioning

confidence: 99%

Frailty predicts a higher risk of incident urolithiasis in 525 368 patients with diabetes mellitus: a population-based study

Chao¹,

Wang

Hung³

et al. 2020

BMJ Open Diab Res Care

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ObjectivePatients with diabetes have an increased risk for urolithiasis, but the associated risk factors remain an active area of research. We investigated whether frailty influenced the probability of patients with diabetes developing urolithiasis.Research design and methodsUsing data from the Longitudinal Cohort of Diabetic Patients from 2004 to 2010, we identified those without and with frailty based on a validated, modified FRAIL scale. Patients were followed until they developed urolithiasis, and we used Kaplan-Meier and Cox proportional hazard regression analyses to examine the relationship between frailty, its severity, and the risk of urolithiasis, accounting for demographic profiles, comorbidities, frailty status changes over follow-up, and medications, with risk competition by mortality.ResultsAmong 525 368 patients with diabetes, 64.4% were not frail, while 28.5%, 6.6%, and 0.6% had 1, 2, and ≥3 FRAIL items at baseline. After 4.2 years of follow-up, 13.4% experienced incident urolithiasis. Cox proportional hazard regression analysis showed that patients with diabetes having at least one FRAIL criterion exhibited a significantly higher risk for urolithiasis compared with non-frail patients (for 1, 2, and ≥3 items, hazard ratio (HR)s: 1.04, 1.23, and 1.46; 95% confidence intervals (CIs) 0.99 to 1.09, 1.12 to 1.35, and 1.12 to 1.91, respectively). This increase in urolithiasis risk remained significant if we restricted analyses to renal stones or recurrent urolithiasis as the study outcomes.ConclusionsFrailty may pose a risk for incident urolithiasis in patients with diabetes. Treating frailty may potentially reduce their risk for urolithiasis.

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A Pilot Study of the FRAIL Scale on Predicting Outcomes in Chinese Elderly People With Type 2 Diabetes

Cited by 78 publications

References 41 publications

Frailty assessment in older adults with chronic obstructive respiratory diseases

Frailty assessment in older adults with chronic obstructive respiratory diseases

Sarcopenia and frailty in older patients with diabetes mellitus

Frailty predicts a higher risk of incident urolithiasis in 525 368 patients with diabetes mellitus: a population-based study

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