A Pilot Study of the Effect of (E, E)-2, 4-Undecadienal on the Offensive Odour of Trimethylamine

Garg, Pankaj; Carpenter, Kevin; Chong, Shanley; Christodoulou, John

doi:10.1007/8904_2012_149

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Thresholds of 62.5 ± 33.1 µmol L −1 for the detection and 188 ± 137 µmol L −1 for the recognition of TMA were established (Table S4, Supporting Information), which is in accordance with previous findings employing a similar setup. [ 45 ]…”

Section: Figurementioning

confidence: 99%

Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study

et al. 2020

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Trimethylamine (TMA) is a metabolite overtly present in patients suffering from trimethylaminuria (TMAU), a rare genetic disorder characterized by a strong “fishy” body odor. To date, no approved pharmacological treatment to sequester excess TMA on the skin of patients exists. Here, transmembrane pH gradient poly(isoprene)‐block‐poly(ethylene glycol) (PI‐b‐PEG) polymersomes are investigated for the topical removal of TMA. PI‐b‐PEG amphiphiles of varying chain length are synthesized and evaluated for their ability to form vesicular structures in aqueous media. The optimization of the PI/PEG ratio of transmembrane pH gradient polymersomes allows for the rapid and efficient capture of TMA both in solution and after incorporation into a topical hydrogel matrix at the pH of the skin. A subsequent double blind olfactory study reveals a significant decrease in perceived odor intensity after application of the polymersome‐based formulation on artificial skin substrates that has been incubated in TMA‐containing medium. This simple and novel approach has the potential to ease the burden of people suffering from TMAU.

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Section: Figurementioning

confidence: 99%