A Pilot Study of Ovarian Cancer Chemoprevention Using Medroxyprogesterone Acetate in an Avian Model of Spontaneous Ovarian Carcinogenesis

Barnes, Mack N.; Berry, W. D.; Straughn, J. Michael; Kirby, Tyler O.; Leath, Charles A.; Huh, Warner K.; Grizzle, William E.; Partridge, Edward E.

doi:10.1006/gyno.2002.6806

Cited by 55 publications

(41 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The laying hen provides an excellent model for studying normal ovarian functions, in particular ovulation [27,28]. The hen also provides an important model for studying ovarian epithelial carcinoma [2,3,23,[29][30][31][32]. In the study reported here, the data demonstrate the relative expression and distribution of COX-1 and COX-2 in the normal ovary compared to alterations in expression observed in ovarian cancer.…”

Section: Discussionmentioning

confidence: 66%

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Hales

Zhuge

Lagman

et al. 2008

Endocr

View full text Add to dashboard Cite

Cyclooxygenase (COX) (PTGS) is the rate-limiting enzyme in the biosynthesis of prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2, which show distinct cell-specific expression and regulation. Ovarian cancer is the most lethal gynecological malignancy and the © Humana Press Inc. 2008 Correspondence to: Dale Buchanan Hales, dbhale@uic.edu. HHS Public Access Author ManuscriptAuthor Manuscript Author ManuscriptAuthor Manuscript disease is poorly understood due to the lack of suitable animal models. The laying hen spontaneously develops epithelial ovarian cancer with few or no symptoms until the cancer has progresses to a late stage, similar to the human disease. The purpose of this study was to examine the relative expression and distribution of COX-1 and COX-2 in the ovaries of normal hens and in hens with ovarian cancer. The results demonstrate that COX-1 was localized to the granulosa cell layer and cortical interstitium, ovarian surface epithelium (OSE) and postovulatory follicle (POF) of the normal ovary. In ovarian cancer, COX-1 mRNA was significantly increased and COX-1 protein was broadly distributed throughout the tumor stroma. COX-2 protein was localized to the granulosa cell layer in the follicle and the ovarian stroma. COX-2 mRNA expression did not change as a function of age or in ovarian cancer. There was significantly higher expression of COX-1 mRNA in the first POF (POF-1) compared to POF-2 and POF-3. COX-2 mRNA expression was not significantly different among POFs. There was no difference in COX-1 or COX-2 mRNA in the OSE isolated from individual follicles in the follicular hierarchy. The results confirm previous findings of the high expression of COX-1 in ovarian tumors further supporting the laying hen as a model for ovarian cancer, and demonstrate for the first time the high expression of COX-1 in POF-1 which is the source of prostaglandins needed for oviposition.

show abstract

Section: Discussionmentioning

confidence: 66%

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Hales

Zhuge

Lagman

et al. 2008

Endocr

View full text Add to dashboard Cite

show abstract

“…The hen maintains an ovulatory cycle lasting 24-26 hours, and the ovulated egg passes through the oviduct, which is roughly comparable to the human fallopian tube, although the oviduct functions as an endocrine organ to complete the development of the egg shell prior to laying (43). The hen does not have a luteal phase and some have postulated that the lack of circulating progesterone is responsible for the increased risk of cancer, not incessant ovulation (44). The hen also does not menstruate and some have speculated that retrograde menstruation is the mechanical force allowing for peritoneal dissemination of uterine cells or FTE (28).…”

Section: Animal Models That Develop Spontaneous Ovarian Carcinomamentioning

confidence: 99%

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

King

Burdette

2011

BMB Reports

View full text Add to dashboard Cite

“…The most relevant feature of the domestic fowl is its high incidence of spontaneous OVAC, which ranges from 11% to 35% between 4 and 6 years of life (6)(7)(8)(9). This makes the chicken unique, relative to other animals that require either experimental induction or genetic engineering to induce ovarian tumors .…”

Section: Introductionmentioning

confidence: 99%

Reduction of Ovarian and Oviductal Cancers in Calorie-Restricted Laying Chickens

Carver

Barnes

Anderson

et al. 2011

Cancer Prevention Research

View full text Add to dashboard Cite

Epithelial ovarian cancer (OVAC) remains a highly lethal malignancy. It is a leading cause of cancer deaths among women in the United States causing more deaths than all other gynecologic malignancies combined. The pathogenesis of OVAC is not completely understood, but the process of repeated ovulation is believed to lead to genetic damage in the ovarian epithelium. As part of a prospective trial designed to evaluate OVAC chemopreventive strategies using the chicken model, caloric restriction (55% less energy) was used to inhibit ovulation in groups of hens receiving chemopreventives, thereby minimizing the impact of ovulation on the incidence of reproductive tract cancer. A separate group of chickens was maintained concurrently in the same environment, and managed similarly, except that caloric intake was not restricted. Among birds not receiving chemopreventive agents, we compared caloric versus noncaloric restricted birds to determine the relations between calorie restriction and risk of developing adenocarcinoma of the reproductive tract. Mortality in the calorie-restricted group was almost half that of those on full feed. Calorie-restricted chickens maintained body weights averaging 1.423 kg compared with the full-fed birds at 1.892 kg. Ovulation rate varied with the full-fed group producing 64% more eggs than the calorierestricted group. Total reproductive cancers occurred in 57 (33.3%) birds for the full-fed group and 26 (10.3%) birds for the calorie-restricted group. On the basis of histopathology, 45 (26.3%) birds in the fullfed group had ovarian adenocarcinoma compared with 16 (6.3%) birds in the calorie-restricted group. Calorie restriction in laying hens resulted in a near five-fold reduction in OVAC. Cancer Prev Res; 4(4); 562-7. Ó2011 AACR.

show abstract

A Pilot Study of Ovarian Cancer Chemoprevention Using Medroxyprogesterone Acetate in an Avian Model of Spontaneous Ovarian Carcinogenesis

Cited by 55 publications

References 11 publications

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

Reduction of Ovarian and Oviductal Cancers in Calorie-Restricted Laying Chickens

Contact Info

Product

Resources

About