A Pilot Study of Noninvasive Methods to Assess Healed Acute and Chronic Wounds

Ho, Diana Q.; Bello, Ysabel M.; Grove, Gary L.; Manzoor, Jasmin; López, Ana Palomares; Zerweck, Charles; Pierce, Elizabeth; Werkheiser, Jennifer L.; Phillips, Tania J.

doi:10.1046/j.1524-4725.2000.99143.x

Cited by 27 publications

(28 citation statements)

References 19 publications

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“…The most common underlying conditions are venous reflux, pressure, and diabetes mellitus 1,2,3,4,5 In the vast majority of surgical procedures, nearly all acute wounds heal by an orderly and timely process 6 , with a strength and integrity similar to normal skin. 7,8 Wounds refractory to moist healing, however, may be candidates for growth factor therapy, which is assumed to stimulate missing or dysfunctional components of the chronic wound [9][10][11] . An angiogenic growth factor may promote closure of chronic wounds exhibiting hypoxia and compromised vascularity.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vascular Endothelial Growth Factor in Wound Healing

Bao

Kodra

Tomic‐Canic

et al. 2009

Journal of Surgical Research

940

732

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Section: Introductionmentioning

confidence: 99%

The Role of Vascular Endothelial Growth Factor in Wound Healing

Bao

Kodra

Tomic‐Canic

et al. 2009

Journal of Surgical Research

940

732

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“…27-32 . Surface electrical capacitance can be used to measure SEM and evaluate restoration of an intact stratum corneum after injury with formation of the epidermal barrier as a function of hydration 27,29,31 . The impedance of the skin to electrical forces is used to calculate surface electrical capacitance, which directly reflects localized edema or water in the epidermal and sub-epidermal tissues.…”

Section: Introductionmentioning

confidence: 99%

Subepidermal Moisture Is Associated With Early Pressure Ulcer Damage in Nursing Home Residents With Dark Skin Tones

Bates‐Jensen

McCreath

Pongquan

2009

Journal of Wound, Ostomy &Amp; Continence Nursing

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OBJECTIVE To examine the relationship between a measure of skin and tissue water, sub-epidermal skin moisture (SEM), and visual assessment of early PU damage in nursing home (NH) residents with dark skin tones. DESIGN, SETTING AND PARTICIPANTS Descriptive, cohort study with 66 residents in four U.S. nursing homes (NH). METHODS Data were pooled from two previous NH studies to evaluate persons with dark skin tones. Data were analyzed for concurrent visual assessments and SEM which were obtained at the right and left buttocks and sacrum weekly for 20 weeks. SEM was measured with a surface electrical capacitance dermal phase meter, where higher readings indicate greater SEM (range: 0-999 dermal phase units [DPU]). Visual assessment was rated as normal, erythema/stage I PU, or stage II+ PU. SEM and specific SEM threshold values (50, 150, 300 DPU) were modeled as detectors of visual assessment of early PU one week later (controlling for clustering and incontinence); with concurrent SEM, and PU risk status, in separate analyses for persons with light and dark skin tones. RESULTS Participants had a mean age of 84 years, were 83% female, 77% non-Hispanic white. Higher SEM predicted greater likelihood of erythema/stage I PU and stage II+ PU in persons with dark skin tones the next week (OR=1.88 for every 100 DPU increase in SEM, p=0.004). When SEM was greater than 50, 150, and 300 DPU, persons with dark skin tones were 8.5, 13, and 10 times more likely to present with stage II+ PU the following week compared to persons with light skin who were 7.2, 3.5, and 4.3 times more likely to present with stage II PU (50, 150, 300 DPU, respectively). SEM threshold of 50 DPU was also significant for detecting erythema/stage I PU in persons with dark skin tones (OR 5.3, CI 1.87—15.11, P<.001). CONCLUSIONS SEM was associated with future (one week later) PU in persons with dark skin tones. SEM threshold values may assist in detecting early PU in persons with dark skin tones, allowing for earlier intervention to prevent PU. These findings should be further evaluated in persons with dark skin tones.

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“…Scar erythema of small wounds on the inner aspect of the upper arms fades over a period of approximately 7 months when evaluated by the naked eye (8). However, only preliminary information is available on the evolution of pigmentation of scars in humans (9).…”

mentioning

confidence: 99%

Erythema Persists Longer than One Year in Split-thickness Skin Graft Donor Sites

Danielsen¹,

Jørgensen²,

Jørgensen³

et al. 2013

Acta Derm Venerol

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The recovery of skin function and appearance after harvest of split-thickness skin autografts is incompletely described. We followed the kinetics of skin restoration after a partial-thickness skin excision relative to adjacent normal skin over 12 months. Standardized donor site wounds were made on the thigh using a pneumatic dermatome in 19 consecutive Caucasian patients, median age 70 years, age range 44-86 years, who were undergoing skin graft surgery for leg ulcers. Transepidermal water loss (TEWL), erythema and pigmentation were measured quantitatively using non-invasive devices. The macroscopically healed wound was compared with adjacent normal skin at 1, 3 and 12 months. At 1 month postoperatively, TEWL was 108% (p = 0.003), erythema 145% (p < 0.0005) and pigmentation 24% (p < 0.001) higher in the wounds compared with adjacent uninjured skin. The corresponding values at 3 months were 48% (p = 0.015), 89% (p < 0.0005) and 15% (p < 0.0005). After 12 months, erythema was elevated by 36% (p < 0.0005), while TEWL (p = 0.246) and pigmentation (p = 0.211) had returned to same levels as in the surrounding normal skin. Diabetes mellitus (p = 0.024) and smoking (p = 0.017) were associated with increased TEWL of normal skin, and erythema decreased with age (rs = -0.53, p = 0.020). In conclusion, erythema appears to be the significant component contributing to long-term postoperative donor site appearance. We hypothesize that this is due to increased microvasculature.

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A Pilot Study of Noninvasive Methods to Assess Healed Acute and Chronic Wounds

Cited by 27 publications

References 19 publications

The Role of Vascular Endothelial Growth Factor in Wound Healing

The Role of Vascular Endothelial Growth Factor in Wound Healing

Subepidermal Moisture Is Associated With Early Pressure Ulcer Damage in Nursing Home Residents With Dark Skin Tones

Erythema Persists Longer than One Year in Split-thickness Skin Graft Donor Sites

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