A Pilot Study of <i>Rhodiola rosea</i> (Rhodax<sup>®</sup>) for Generalized Anxiety Disorder (GAD)

Bystritsky, Alexander; Kerwin, Lauren; Feusner, Jamie D.

doi:10.1089/acm.2007.7117

Cited by 88 publications

(45 citation statements)

References 32 publications

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“…Several clinical trials have shown that SHR-5 improved mental performance and attention in cognitive function in fatigue after single and repeated administration [44, 53, 54], and prevented physical, emotional, and mental exhaustion in patients with fatigue syndrome [43]. SHR-5 was also shown to be effective in the treatment of mild to moderate depression [42] and generalized anxiety [54, 55] in clinical trials. Due to the rapidly growing demand for Rhodiola-based products on the market during a past few years, Rhodiola has been considered to be endangered plant species in many countries [16].…”

Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

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Purpose of review Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. Recent findings In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’s action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through down-regulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Summary Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.

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Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

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“…Despite its excellent safety profile, golden root might be not suitable for patients with bipolar spectrum disorders because of its activating effect, which could increase patients' risk of cycling (Iovieno et al, 2011). In addition, the most common side effects of golden root involve irritability and insomnia (Bystritsky et al, 2008). Minor effects on CYP3A4 and p-glycoprotein were reported (Hellum et al, 2010).…”

Section: Golden Root (Rhodiola Rosea)mentioning

confidence: 99%

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Baek

Nierenberg

Kinrys

2014

Aust N Z J Psychiatry

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Objectives: Patients with bipolar disorder frequently continue to experience residual anxiety and insomnia between mood episodes. In real-world practice, patients increasingly self-prescribe alternative medicines. Methods:We reviewed case reports, open-label, and placebo-controlled trials investigating the use of herbal medicines to treat anxiety and insomnia, and discussed their potential applications for bipolar disorder.Results: Eleven herbal medicines that have been studied in human subjects are included in this review. Mechanisms of action, efficacy, side effects, and drug-drug interactions are discussed. Based on currently available evidence, valerian seems to be the most promising candidate for insomnia and anxiety in bipolar disorder. Conclusions:Adjunctive herbal medicines may have the potential to alleviate these symptoms and improve the outcomes of standard treatment, despite limited evidence. Physicians need to have a more in-depth understanding of the evidence of benefits, risks, and drug interactions of alternative treatments.

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“…Several traditional herbal medicines, such as Valeriana officinalis ,[9394] Passiflora incarnata ,[9596] Matricaria recutita L.,[9798] Humulus lupulus ,[99100] Ginkgo bibola ,[101] Centella asiatica ,[102] Rhodiola rosea ,[103] Hypericum perforatum ,[104] Piper methysticum [105106] and Zizyphus jujuba [14] have been widely clinically reported to improve sleep and other mental disorders. Moreover, recently Wuling capsule, a single herb formula from mycelia of precious Xylaria nigripes was investigated for its efficacy and safety, through a multicenter, randomized, double-blind, placebo-controlled trail, in Chinese patients with insomnia.…”

Section: Clinical Studies Done On Polygonum Multiflorum And/or Its Bimentioning

confidence: 99%

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

Bounda

2015

Phcog Res

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Polygonum multiflorum Thunb. (PMT), officially listed in the Chinese Pharmacopoeia, is one of the most popular perennial Chinese traditional medicines known as He shou wu in China and East Asia, and as Fo-ti in North America. Mounting pharmacological studies have stressed out its key benefice for the treatment of various diseases and medical conditions such as liver injury, cancer, diabetes, alopecia, atherosclerosis, and neurodegenerative diseases as well. International databases such as PubMed/Medline, Science citation Index and Google Scholar were searched for clinical studies recently published on P. multiflorum. Various clinical studies published articles were retrieved, providing information relevant to pharmacokinetics-pharmacodynamics analysis, sleep disorders, dyslipidemia treatment, and neurodegenerative diseases. This review is an effort to update the clinical picture of investigations ever carried on PMT and/or its isolated bio-compounds and to enlighten its therapeutic assessment.

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A Pilot Study of Rhodiola rosea (Rhodax^®) for Generalized Anxiety Disorder (GAD)

Abstract: Significant improvement in GAD symptoms was found with R. rosea, with a reduction in HARS scores similar to that found in clinical trials. These preliminary findings warrant further exploration of treatment with R. rosea in clinical samples.

Cited by 88 publications

References 32 publications

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

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A Pilot Study of Rhodiola rosea (Rhodax®) for Generalized Anxiety Disorder (GAD)

Abstract: Significant improvement in GAD symptoms was found with R. rosea, with a reduction in HARS scores similar to that found in clinical trials. These preliminary findings warrant further exploration of treatment with R. rosea in clinical samples.

Cited by 88 publications

References 32 publications

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds

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A Pilot Study of Rhodiola rosea (Rhodax^®) for Generalized Anxiety Disorder (GAD)