A pilot study of a culturally-appropriate, educational intervention to increase participation in cancer clinical trials among African Americans and Latinos

Cunningham-Erves, Jennifer; Mayo-Gamble, Tilicia; Hull, Pamela C.; Lu, Tao; Barajas, Claudia; McAfee, Caree; Sanderson, Maureen; Canedo, Juan; Beard, Katina; Wilkins, Consuelo H.

doi:10.1007/s10552-021-01449-7

Cited by 18 publications

(10 citation statements)

References 47 publications

(52 reference statements)

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“…Researchers have demonstrated the importance of culturally tailored education design to improve health outcomes and enhance diversity in clinical trials, which has significantly contributed to the field of health disparities ( 38 , 39 , 41 ). However, given the scarcity of culturally tailored community-based recruitment methodology for ADRD among older African Americans, this study provides evidence to support the potential utility of future culturally tailored community-based recruitment methods for ADRD clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…Cunningham-Erves et al (2021) examined the effect of a culturally tailored educational program to enhance participation in cancer trials among African Americans and Latinos. Results demonstrated that the culturally tailored curriculum increased willingness to participate in research and improved trust between the researchers and the community ( 41 ). This paper expands on the current literature around culturally tailored education by focusing on a disease that disproportionally impacts the African American community.…”

Section: Introductionmentioning

confidence: 99%

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Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

et al. 2022

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Alzheimer’s disease and related dementias (ADRD) is two times more prevalent among compared to non-Hispanic Whites. Despite the higher prevalence of ADRD among older African Americans, recent estimates suggest research enrollment by those who identify as African American remains limited. The purpose of the study is to 1) explore how a culturally tailored community education program impacts clinical trial interest and enrollment in ADRD research studies and to 2) identify how applicable the African American community perceived the culturally tailored curriculum. Using a community-engaged research approach, we collaborated with predominately African American serving community-based organizations to support content development and delivery of Aging with Grace (AWG), a culturally tailored ADRD educational curriculum. A total of five AWG presentations were given to 66 attendees. Most attendees (67%) expressed interest in participating in clinical trials after attending AWG. Enrollment increased within an observational study (84%) and lifestyle prevention clinical trials (52%) from 2018 to 2019. Attendees (32%) also perceived an increase in ADRD knowledge from attending AWG and 89.1% believed more African Americans should participate in research. Our work demonstrates the effectiveness of a culturally tailored community education program to enhance knowledge, clinical trial interest, and recruitment into observational studies and lifestyle ADRD clinical trials among older African Americans. Education programs developed in partnership with the community can serve as bridge to research participation for underrepresented minorities in clinical research. Future studies should assess long-term retention of knowledge and research readiness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

et al. 2022

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“…Exclusion criteria were as follows: (1) case studies, review articles, and studies focused only on identifying an inequity or disparity in cancer care. While educational programs to either increase knowledge, beliefs, and attitudes about cancer screening 16,17 or increase participation in clinical research trials 18 have been well-studied, we were specifically interested in methods or interventions that measured an impact on one or more cancer-related health equity metrics.…”

Section: Methodsmentioning

confidence: 99%

Cancer‐Specific health equity metrics in the United States of America: A scoping review

et al. 2023

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“…Given elevated disease burden and poorer cancer outcomes among the underserved, it is critical that trial participation disparities are investigated [7,9]. Moreover, recent literature indicates that implementation of patient-centered, culturally sensitive recruitment strategies tailored toward CCT engagement among underrepresented populations in cancer research have yielded positive implications for attenuating inequities in CCT participation [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Accrual and retention of diverse patients in psychosocial cancer clinical trials

Hanvey

Padrón

Kacel

et al. 2022

J. Clin. Trans. Sci.

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Background: Minority and older adult patients remain underrepresented in cancer clinical trials (CCTs). The current study sought to examine sociodemographic inequities in CCT interest, eligibility, enrollment, decline motivation, and attrition across two psychosocial CCTs for gynecologic, gastrointestinal, and thoracic cancers. Methods: Patients were approached for recruitment to one of two interventions: (1) a randomized control trial (RCT) examining effects of a cognitive-behavioral intervention targeting sleep, pain, mood, cytokines, and cortisol following surgery, or (2) a yoga intervention to determine its feasibility, acceptability, and effects on mitigating distress. Prospective RCT participants were queried about interest and screened for eligibility. All eligible patients across trials were offered enrollment. Patients who declined yoga intervention enrollment provided reasons for decline. Sociodemographic predictors of enrollment decisions and attrition were explored. Results: No sociodemographic differences in RCT interest were observed, and older patients were more likely to be ineligible. Eligible Hispanic patients across trials were significantly more likely to enroll than non-Hispanic patients. Sociodemographic factors predicted differences in decline motivation. In one trial, individuals originating from more urban areas were more likely to prematurely discontinue participation. Discussion: These results corroborate evidence of no significant differences in CCT interest across minority groups, with older adults less likely to fulfill eligibility criteria. While absolute Hispanic enrollment was modest, Hispanic patients were more likely to enroll relative to non-Hispanic patients. Additional sociodemographic trends were noted in decline motivation and geographical prediction of attrition. Further investigation is necessary to better understand inequities, barriers, and best recruitment practices for representative CCTs.

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A pilot study of a culturally-appropriate, educational intervention to increase participation in cancer clinical trials among African Americans and Latinos

Cited by 18 publications

References 47 publications

Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

Cancer‐Specific health equity metrics in the United States of America: A scoping review

Accrual and retention of diverse patients in psychosocial cancer clinical trials

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