A pilot study evaluating the anti‐aging benefits of a CO₂‐emitting facial mask

Abstract

Background Since 1936, injectable carboxytherapy has been used for the treatment of circulatory issues and lack of tissue trophism. In the last 25 years, it has been applied to aesthetic issues, especially those related to the signs and symptoms of skin aging. Presently, carboxytherapy is available as a combination of transcutaneous gels that produce CO2 with benefit for atrophic skin. Objective The objective of this study was to investigate the efficacy and safety of a topical carboxy mask on facial photoaging after short term use of 4 weeks and long term use of 10 weeks. Methods The short term study was conducted for 14 days after 3 times weekly application of the facial mask for 1 h followed by a regression phase with evaluations at days 21 and 28. 11 healthy female subjects age 45–75 years were enrolled. Subjects applied the facial mask for 45 min, 3 times per week during the 2‐week treatment period. The long term study was conducted for 10 weeks on 35 subjects 35–65 years with mild to moderate facial photoaging of Fitzpatrick skin types I–VI. Subjects underwent photography, elasticity, hydration, and VAS questionnaire assessments. Results The short term 4 week study demonstrated improvement in laser‐Doppler measured blood flow and skin hydration. The long term 10 week study demonstrated improvement in firmness (16%, p = 0.001), sagging (9%, p = 0.023), and overall skin appearance (12%, p = 0.002). These findings were supported by the retraction time decrease at week 10 (−10%, p = 0.05). Summary The combination of two gels produced the liberation of CO2, which improved short term skin hydration after 4 weeks of use and improved longer term skin elasticity after 10 weeks of use.

The role of the beautician in reducing striae

“…More recently, treatments with carboxytherapy have been used to stimulate the growth of collagen and elastin, reduce fatty tissue, treat scars and striae, eliminate wrinkles, and solve many other skin problems. [34][35][36][37] Hodeib et al enrolled 20 patients with striae in their study. Each patient received one carboxytherapy treatment on the left side of the body and one PRP treatment on the right side of the body.…”

Effectiveness of Applying Anti-Aging Cream with Lemon Peel Extract (Citrus Limon) in Inhibiting the Skin Aging Process of Wistar Rats (Rattus Norvegicus) Exposed to Ultra Violet-B Rays

“…Wrinkles and fine lines signify premature aging. There are also dark spots and facial elasticity issues [1]. Premature aging causes skin to dry and darken, and acne scars take longer to erase.…”

The Effect of Giving Aloe Vera Gel on Collagen Growth in Wistar Rats (Rattus Norvegicus) with Exposure to Ultra Violet-B Light

“…However, premature aging is concerning. Several reasons cause aging, including psychological stress, pollution, and smoking [8]- [10].…”

“…This study was coordinated with prior studies that found PAHs (polycyclic aromatic hydrocarbons) attached to combustion nanoparticles, which cause facial pigmentation. This may explain why industrial or heavily polluted locations have more lentigines and melasma [10]. Another skin-damaging combustion is cigarette smoke.…”

“…Even short-term UV exposure increases MMP-1 activity in the skin, generating wrinkles and photoaging. UV light for several hours causes MMPs, especially gelatinase and collagenase, which degrade dermal collagen [3], [10], [21].…”