A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence

Abstract

The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP’s clinical applications.

Platelets Rich Plasma Injections in The Treatment for Stress Urinary Incontinence in Postmenopausal Women

“…And only 5 cases not improved in grade of severity of incontinence with percentage of 16.7 % of the cases as shown in Table .9. In agreement to our work, a study done by Long, et al, (2021) [13] that aimed to estimate the efficacy of regional injection of autologous platelet rich plasma (A-PRP) as a handling for females suffering from stress urinary incontinence (SUI). In this potential intervention trial, 20 consecutive females suffering from SUI were cured with A-PRP injection at the frontal vaginal wall where mid-urethra is located; their average age was 44.5 years old, with 1.6 times average parity and a BMI of 22.7 mg/m2.…”

Therapeutic Efficacy and Mid-Term Durability of Urethral Sphincter Platelet-Rich Plasma Injections to Treat Postprostatectomy Stress Urinary Incontinence

“…Women with SUI who received PRP injections achieved a slightly higher treatment success rate, as defined by cure and improved symptoms, in the younger group [ 13 ]. The results herein and from our previous studies are not concurrent with previous findings in the reported literature, as the influence of age on clinical outcomes was not significant [ 12 , 14 ].…”

“…In 2016, the potential role of PRP in treating SUI was first proposed [ 9 ] and was applied in an animal model in 2019, in which a significant increase in leak point pressure was observed [ 10 ]. Based on the hypothesis that deficient urethral sphincter function improves following regenerated innervation and increased striated muscle cell volume via repeated PRP urethral sphincter injections, several recent studies have shown the safety and therapeutic efficacy of autologous PRP urethral sphincter injections for the treatment of SUI in humans [ 11 , 12 , 13 , 14 ].…”

Cosmetic Gynecology: Present and Future Perspectives

“…They found that PRP treatment is effective in relieving SUI symptoms without significant adverse reactions at both 1 month and 6 month follow up. PRP is also used as an adjunct therapy along with energy-based devices procedures to enhance the efficacy of the treatment [30] . In another study by Willison F et al 2021, feasibility, safety, and efficacy of FxCO 2 (Fractional Microablative CO 2 ) vaginal laser treatment and PRP was evaluated in 62 women with refractory urge urinary incontinence (UUI) with urinary function and sexual function as secondary outcome measures.…”