A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury

Waits, Charlotte Mae K.; Bower, Aaron; Simms, Kelli N; Feldman, Bradford; Kim, Nathan; Sergeant, Susan; Chilton, Floyd H.; VandeVord, Pamela J.; Langefeld, Carl D.; Rahbar, Elaheh

doi:10.1089/neu.2019.6734

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…Acute trauma is characterized by complex disease, a high disability rate and fatality rate, and it is difficult to treat. Currently, it is the main cause of death for people under the age of 45 [ 11 ]. Therefore, in order to improve the efficiency and quality of trauma diagnosis and treatment and reduce the mortality risk of acute trauma patients, it is particularly important to quickly and accurately assess the severity of acute trauma patients, triage trauma patients in a timely manner, and then take effective treatment measures.…”

Section: Discussionmentioning

confidence: 99%

Early Mortality Risk in Acute Trauma Patients: Predictive Value of Injury Severity Score, Trauma Index, and Different Types of Shock Indices

Dai

Xing

et al. 2022

JCM

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Objective: This study aimed to explore the predictive value of the Injury Severity Score (ISS), Trauma Index (TI) and different types of shock indices (SI) on the early mortality risk of acute trauma patients. Methods: Clinical data of acute trauma patients who met the inclusion and exclusion criteria of this study and were treated in the hospital from January 2020 to December 2020 were retrospectively collected, including gender, age, trauma mechanism, severe injury site, ISS, TI, admission vital signs, different types of shock indices (SI), death within 7 days, length of hospital stay, and Glasgow Outcome Score (GOS). The predictive value of the Injury Severity Score, Trauma Index, and different types of shock indices on the risk of early mortality in patients with acute trauma were compared using relevant statistical methods. Results: A total of 283 acute trauma patients (mean age 54.0 ± 17.9 years, 30.74% female) were included, and 43 (15.19%) of the patients died during 7 days of hospitalization. The admission ISS, TI, SI, MSI, and ASI in the survival group were significantly lower than those in the death group, and the difference was statistically significant (p < 0.05). Meanwhile, different trauma assessment tools included in the study have certain predictive value for early mortality risk of trauma patients. Conclusions: The TI indicates a better capability to predict the risk of early death in patients with acute trauma. As the most sensitive predictor, the SI has the greatest reference value in predicting the risk of early death in patients with traumatic shock.

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Section: Discussionmentioning

confidence: 99%

Early Mortality Risk in Acute Trauma Patients: Predictive Value of Injury Severity Score, Trauma Index, and Different Types of Shock Indices

Dai

Xing

et al. 2022

JCM

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“…Genetic variants and their association with PUFA status Regarding genetic analyses, previous studies described that people with the T allele of rs174537 polymorphism in FADS1 have lower AA levels and get more benefit from n-3 PUFA than those with the GG allele [16,72]. The GG genotype of rs174537 is linked with increased PUFA-derived eicosanoid levels that influence downstream inflammatory pathways [73,74]. The minor allele T of rs174537 is associated with decreased risk of major depressive disorder and breast cancer among women [72,75].…”

Section: Age-associated Changes In Fa Profilementioning

confidence: 99%

Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals

et al. 2022

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Gas chromatography was employed to determine the FA profile, and genotyping was performed using high-resolution melt (HRM) analysis. Blood levels of total polyunsaturated FA (PUFA) and total trans-FA decreased with age, while the levels of saturated FA (SFA) remained unchanged. Interestingly, distinctively higher circulatory levels of monounsaturated FA (MUFA) in LLIs compared to adults and older adults were observed. In addition, among LLIs, rs174537 in the FA desaturase 1/2 (FADS1/2) gene was associated with linoleic acid (LA, 18:2n-6) and docosatetraenoic acid (DTA, 22:4n-6) levels, and the rs953413 in the elongase of very long FA 2 (ELOVL2) was associated with DTA levels. We further observed that rs174579 and rs174626 genotypes in FADS1/2 significantly affect delta-6 desaturase (D6D) activity. In conclusion, our results suggest that the LLIs have a different FA profile characterized by high MUFA content, which indicates reduced peroxidation while maintaining membrane fluidity.

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Interaction analysis of FADS2 gene variants with chronic hepatitis B infection in Chinese patients

Sun

Gao

Shi

et al. 2022

Infection, Genetics and Evolution

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A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury

Cited by 4 publications

References 63 publications

Early Mortality Risk in Acute Trauma Patients: Predictive Value of Injury Severity Score, Trauma Index, and Different Types of Shock Indices

Early Mortality Risk in Acute Trauma Patients: Predictive Value of Injury Severity Score, Trauma Index, and Different Types of Shock Indices

Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals

Interaction analysis of FADS2 gene variants with chronic hepatitis B infection in Chinese patients

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