A Pilot Split-Face Study Comparing Conventional Methyl Aminolevulinate-Photodynamic Therapy (PDT) With Microneedling-Assisted PDT on Actinically Damaged Skin

Torezan, Luís; Chaves, Yuri Nogueira; Niwa, Ane Beatriz Mautari; Sanches, José Antônio; Festa-Neto, Cyro; Szeimies, Rolf‐Markus

doi:10.1111/dsu.12233

Cited by 87 publications

(59 citation statements)

References 5 publications

(13 reference statements)

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“…One study reported infections with herpes simplex virus (HSV), but it was unclear if these patients had acne scarring (Aust et al, 2008a). Reports of HSV infections have been noted in other articles (Fernandes, 2005, Torezan et al, 2013) and oral acyclovir was given to patients with a history of HSV in at least one study including patients with acne scarring (Alam et al, 2014). …”

Section: Resultsmentioning

confidence: 98%

“…Fine needles puncture the skin, resulting in increased dermal elastin and collagen, collagen remodeling, and thickening of the epidermis and dermis (Aust et al, 2008a, Aust et al, 2010a, Aust et al, 2010b, Aust et al, 2011, Fabbrocini et al, 2011a, Fernandes, 2005, Fernandes and Signorini, 2008, Kim et al, 2011, Park et al, 2012, Schwarz and Laaff, 2011). Additionally, skin needling creates small channels, which increase the absorption of topically applied preparations (Badran et al, 2009, Kalluri et al, 2011), a property which has been used in various dermatological treatments (Bencini et al, 2012, Budamakuntla et al, 2013, Clementoni et al, 2010, Fabbrocini et al, 2011b, Fabbrocini et al, 2014a, Kang et al, 2008, Torezan et al, 2013, Yoon et al, 2008, Yoon et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

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Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Harris

Naidoo

Murrell

2015

International Journal of Women's Dermatology

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BackgroundSkin needling is a technique used to improve the appearance of acne scarring.ObjectiveTo comprehensively review the medical literature regarding skin needling as a treatment for acne scarring.MethodsA literature search was performed using the PubMed, Medline, and Embase databases, in addition to reviewing the bibliographies of relevant articles.ResultsTen studies presented patients treated with skin needling alone, while eight studies discussed skin needling in combination with other treatments for acne scarring. All studies showed improvements in scarring after needling, with 12 reporting statistical significance. The median number of treatments when needling was used alone was three, the median duration between treatments was 4 weeks, and the median needle length used was 1.5 mm. Reported adverse events were infrequent and included post-inflammatory hyperpigmentation, “tram track” scarring, acne, and milia. There were no reports of bacterial infections.LimitationsThe studies reviewed were heterogeneous in design and of variable validity, with some not reporting statistical significance.ConclusionThere is moderate evidence to suggest that skin needling is beneficial and safe for the treatment of acne scarring. However, double-blinded, randomized controlled trials are required to make more definitive conclusions.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Harris

Naidoo

Murrell

2015

International Journal of Women's Dermatology

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“…The most recent studies include use of keratolytics, curettage/debulking, tape stripping, microdermabrasion, and laser ablation 21,45,46. One split-face study demonstrated slightly superior efficacy and long-term improvement of actinic keratoses when using microneedling as a delivery system 47. Use of microneedling in SCC in situ and BCC failed to demonstrate either increased fluorescence uptake or clinical superiority.…”

Section: Light Source and Methods Of Deliverymentioning

confidence: 99%

Current evidence and applications of photodynamic therapy in dermatology

Wan¹,

Lin²

2014

CCID

114

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In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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“…In one study, Torezan [37] et al reported treating ten patients with facial photodamage and actinic keratoses with MAL-PDT or microneedling-assisted PDT. In this prospective, randomized, split face study, they were able to demonstrate the effectiveness of both modalities in the treatment of photodamage, mottled pigmentation, roughness and sallowness, with the superior efficacy of microneedling-assisted PDT compared to MAL-PDT alone on fine lines at day 30.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Wen

Hamblin

2017

Photodiagnosis and Photodynamic Therapy

155

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Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.

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A Pilot Split-Face Study Comparing Conventional Methyl Aminolevulinate-Photodynamic Therapy (PDT) With Microneedling-Assisted PDT on Actinically Damaged Skin

Abstract: Microneedling-assisted PDT is a safe and effective method and can produce superior cosmetic results to conventional MAL-PDT for improving photodamaged skin. Further larger prospective studies are needed to determine whether the addition of MN decreases actinic keratosis.

Cited by 87 publications

References 5 publications

Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Skin needling as a treatment for acne scarring: An up-to-date review of the literature

Current evidence and applications of photodynamic therapy in dermatology

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

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