“…Importantly, a comparison of in vitro-and in vivo-generated blastocysts found no differences in aneuploidy or mosaicism rates (48). Mosaicism after natural conception may also be underestimated, as recently higher rates were observed in first trimester miscarriages when multiple site sampling was performed (49). Overall, evidence from miscarriages, chorionic villus sampling, and analysis of term placentas shows that mosaicism associated with IVF persists beyond the preimplantation embryo at a rate similar to that associated with spontaneous conception (50)(51)(52).…”