A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes

Begum, Thoin F.; Fujimoto, Victor Y.; Gerona, Roy; McGough, Alexandra; Lenhart, Nikolaus; Wong, Rebecca S. Y.; Mok-Lin, Evelyn; Melamed, Jonathan; Butts, Celeste D.; Bloom, Michael S.

doi:10.1016/j.reprotox.2020.11.014

Cited by 19 publications

(10 citation statements)

References 49 publications

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“…A considerable amount of epidemiological data are present in the literature linking phthalate exposure with poor IVF and fertility outcomes. In short, studies investigating IVF data have reported that increased urinary levels of phthalates were associated with lower total and mature egg yield, decreased numbers of clinical pregnancies, and decreased live births depending upon the cohort studied and metabolite measured (Begum et al, 2021 ; Deng et al, 2020 ; Hauser et al, 2016 ; Machtinger et al, 2018 ; Mínguez‐Alarcón et al, 2019 ). In fact, one study suggested that plasma levels of certain phthalates were increased in infertile women compared to fertile women (Pednekar et al, 2018 ), while another has reported that increased urinary levels of monoethyl phthalate (MEP) were associated with decreased fecundity and a longer time to pregnancy (Thomsen et al, 2017 ).…”

Section: Phthalatesmentioning

confidence: 99%

“…Following fertilization, monomethyl phthalate (MMP) and MEP levels were associated with reduced odds to gain a good quality blastocyst (Deng et al, 2020 ). Similarly, doublings in women's urinary MBP and monohexyl phthalate (MHxP) levels were associated with a lower likelihood of pregnancy and live birth, respectively (Begum et al, 2021 ). Interestingly, when follicular fluid is used as the matrix to measure phthalate levels, these associations with poor IVF outcomes are no longer present (Y. Y.…”

Section: Phthalatesmentioning

confidence: 99%

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The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Land

Miller

Fugate

et al. 2022

Molecular Reproduction Devel

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Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation. Defects in ovulation are the leading cause of infertility in women, and EDC exposures are contributing to the prevalence of infertility. Thus, investigating the effects of EDCs on the ovary and ovulation is an emerging area for research and is the focus of this review. The effects of EDCs on gametogenesis, uterine function, embryonic development, and other aspects of fertility are not addressed to focus on ovarian‐ and ovulation‐related fertility issues. Herein, findings from epidemiological and basic science studies are summarized for several EDCs, including phthalates, bisphenols, per‐ and poly‐fluoroalkyl substances, flame retardants, parabens, and triclosan. Epidemiological literature suggests that exposure is associated with impaired fecundity and in vitro fertilization outcomes (decreased egg yield, pregnancies, and births), while basic science literature reports altered ovarian follicle and corpora lutea numbers, altered hormone levels, and impaired ovulatory processes. Future directions include identification of the mechanisms by which EDCs disrupt ovulation leading to infertility, especially in women.

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Section: Phthalatesmentioning

confidence: 99%

Section: Phthalatesmentioning

confidence: 99%

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Land

Miller

Fugate

et al. 2022

Molecular Reproduction Devel

View full text Add to dashboard Cite

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“…In particular, women in the highest quartile of DEHP level had, on average, lower probabilities of implantation (−22%), clinical pregnancy (−24%) and live birth (−38%) compared to women of the lowest quartile [63]. High exposure to MnBP and MEHP was statistically significantly associated with a lower likelihood of pregnancy, and the same result was obtained with cumulative exposure of different phthalates (MEP, MnBP, and mono-n-pentylphthalate; MEHP, MEHHP, MiNP, MBzP, and mono(2-ethyl-5-carboxypentyl)phthalate) [64].…”

Section: Discussionmentioning

confidence: 69%

Female Reproductive Health and Exposure to Phthalates and Bisphenol A: A Cross Sectional Study

Caporossi

Viganò

Paci

et al. 2021

Toxics

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The xenoestrogenicity of some plasticisers (phthalates and bisphenol A) is documented in the literature and may pose a risk to female reproductive health. The aim of this study was to assess exposure to six phthalates. This was achieved by measuring their respective metabolites (mono-ethylphthalate (MEP); mono-n-butylphthalate (MnBP); mono-n-ottylphthalate (MnOP); and monobenzylphthalate (MBzP)), as well as the sum of two of the diethyl-hexyl phthalate metabolites-(∑DEHP) and bisphenol A (BPA) in a female population with infertility problems, and by conducting a correlation analysis between infertility factors, work activities, and lifestyle habits, in order to formulate a causal hypothesis. A cross-sectional epidemiological study was carried out and women under 43 years of age were recruited from an assisted reproduction technology (ART) center; the sample of 186 women was given a specific questionnaire and a spot urine sample was collected. Phthalate metabolites and urinary BPA were analyzed by HPLC/MS/MS. The results showed significantly higher mean values for MEP in women with recurrent pregnancy loss (RPL) (820.5 ± 1929.5 µg/g of creatinine) and idiopathic infertility (230.0 ± 794.2 µg/g of creatinine) than in women with other infertility factors (76.9 ± 171.8 µg/g of creatinine). Similarly, for MnOP levels, women with idiopathic infertility (2.95 ± 3.44 µg/g of creatinine) showed significantly higher values than women with the other infertility factors taken together (1.35 ± 2.05 µg/g of creatinine). Women with tubal factors of infertility, RPL, and endocrine dysfunctions show higher values of DEHP (p = 0.032). Considering occupations, women working in commerce showed more than twice as much urinary BPA levels (1.10 ± 0.48 µg/g of creatinine) compared to women working in other industries (0.45 ± 0.35 µg/g of creatinine). The presence of significantly higher values of certain phthalates, DEHP in particular, especially in women with RPL and idiopathic infertility, suggests a possible involvement of these compounds as competing factors in reproductive issues. The study of sources of exposure suggested that the working activity in trade, as a casher in particular, represents a major one for BPA (p = 0.015).

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“…Additionally, recent investigations demonstrated that paternal mixtures of urinary concentrations phthalate metabolites are related to higher failure to IVF (Begum et al, 2021;Mínguez-Alarcón et al, 2021). For this reason, the authors highlight the importance of studying the paternal role when carrying out studies of exposure to EDCs during pregnancy (Begum et al, 2021;Mínguez-Alarcón et al, 2021).…”

Section: In Vitro Fertilizationmentioning

confidence: 97%

Update about the disrupting‐effects of phthalates on the human reproductive system

Mesquita

Lorigo

Cairrão

2021

Molecular Reproduction Devel

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Phthalate esters are synthetic chemicals used in the plastic industry as plasticizers and consumable products. According to United Nations, about 400 million tons of plastic are produced every year. In parallel with increased production, the concerns about its effects on human health have increased because phthalates are endocrinedisrupting compounds. Humans are continuously exposed to phthalates through different routes of exposure. Experimental data have associated the phthalates exposure to adverse effects on development and reproduction in women (e.g., earlier puberty, primary ovarian insufficiency, endometriosis, preterm birth, or in vitro fertilization) and men (e.g., anogenital distance, cryptorchidism, hypospadias, and changes in adult reproductive function) although there is no consensus. Therefore, one question arises: could the increase in infertility be related to phthalates exposure? To answer this question, we aimed to assess the disruptingeffects of phthalates on the human reproductive system. For this, we reviewed the current literature based on epidemiological and experimental data and experimental studies in humans. The phthalate effects were discussed in a separate mode for female and male reproductive systems. In summary, phthalates induce toxicity in the reproductive system and human development. The increased plastic production may be related to the increase in human infertility.

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A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes

Cited by 19 publications

References 49 publications

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Female Reproductive Health and Exposure to Phthalates and Bisphenol A: A Cross Sectional Study

Update about the disrupting‐effects of phthalates on the human reproductive system

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