A Pilot Exercise Intervention to Improve Lower Extremity Functioning in Peripheral Arterial Disease Unaccompanied by Intermittent Claudication

McDermott, Mary M.; Tiukinhoy, Susan; Greenland, Philip; Liu, Kiang; Pearce, William H.; Guralnik, Jack M.; Unterreiner, Shay; Gluckman, Ty J.; Criqui, Michael H.; Ferrucci, Luigi

doi:10.1097/00008483-200405000-00010

Cited by 37 publications

(47 citation statements)

References 34 publications

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“…The observed improvements in WIQ domains were similar to those that have previously reported for claudication severity, distance, and speed after programs of treadmill walking exercise lasting 12 to 24 weeks in some studies. 11,12,34 This shows that alternative, relatively pain-free exercise modalities such as arm-cranking can evoke improvements in perceived lower-limb functional status that are comparable to the changes observed after programs of more painful lowerlimb weight-bearing exercise.…”

Section: Discussionmentioning

confidence: 74%

Upper- versus lower-limb aerobic exercise training on health-related quality of life in patients with symptomatic peripheral arterial disease

Saxton

Zwierska

Blagojevic

et al. 2011

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 74%

Upper- versus lower-limb aerobic exercise training on health-related quality of life in patients with symptomatic peripheral arterial disease

Saxton

Zwierska

Blagojevic

et al. 2011

Journal of Vascular Surgery

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“…In our cohort, the association between depressive symptoms and functional decline was present even after accounting for frequency of walking for exercise in multivariable models. Supervised and self-directed exercise has been shown to be associated with improvement or less decline in lower extremity performance among patients with PAD (27,36,37). However, other studies have not demonstrated consistent benefits of unsupervised exercise on walking performance (37,38).…”

Section: Discussionmentioning

confidence: 99%

Persistent Depressive Symptoms and Functional Decline Among Patients With Peripheral Arterial Disease

Ruo

Liu

Tian

et al. 2007

Psychosomatic Medicine

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Objective-Because depressive symptoms are prevalent among patients with peripheral arterial disease (PAD), our goal was to study the effect of depressive symptoms over time on functional decline among patients with PAD.Methods-We conducted a prospective cohort study of 417 patients with PAD followed annually for 2 years. A Geriatric Depression Scale Short Form (GDS-S) score >5 was considered positive for depressive symptoms. Depressive symptom categories based on annual GDS-S measures included persistent, new, resolved, and no depressive symptoms. Outcome variables were change in 6-minute walk distance, 4-meter fast walking velocity, and short physical performance battery (0-12 scale, 12 = best). Results are adjusted for age, sex, race, body mass index, marital status, exercise level, smoking, ankle brachial index, leg symptoms, comorbidities, beta-blocker medication use, antidepressant medications, and interim medical events.Results-In adjusted analyses, patients with new depressive symptoms had greater annual decline in fast walking velocity compared with that of patients with no depressive symptoms (−0.08 versus −0.01 meters/second per year, p = .02). Patients with persistent depressive symptoms had greater annual decline in 6-minute walk distance (−86.4 versus −41.5 feet/yr, p = .04), fast walking velocity (−0.08 versus −0.01 meters/second per year, p = .004), and short physical performance battery (−0.73 versus −0.18 per year, p = .005) compared with that of patients with no depressive symptoms.Conclusions-Among patients with PAD, persistent and new depressive symptoms are associated with greater annual decline in functional performance. Further study is needed to determine the mechanisms of these associations and whether treatment of depressive symptoms prevents functional decline in persons with PAD.

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“…The training benefits the patients by improving walking capacity, delaying occurrence of claudication and increasing tolerance to pain. [5][6][7][8] Research has examined whether the improved walking capacity was related to the changes in skeletal F o r P e e r R e v i e w muscle histology, 9 muscular enzyme activities, 9 walking economy, 6,10 and muscle strength or endurance. 7,11 However, the exact mechanism for the beneficial effects is still unclear.…”

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confidence: 99%

Effects of Supervised Treadmill Walking Training on Calf Muscle Capillarization in Patients with Intermittent Claudication

Wang

Zhou²,

Bronks³

et al. 2008

Angiology

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The aim of this study was to evaluate the effects of supervised treadmill-walking training on the calf muscle capillarization in patients with intermittent claudication. The first 12-week period was a non-exercise, within-subject control stage and the second 12-week period was an exercise training stage. Calf muscle biopsy samples were obtained at baseline, pre-and post-exercise training. Functional capacities were measured after each biopsy. Eleven subjects completed all procedures. Their average age was (mean ± SD) 73.9 ± 5.5 years, resting ankle-to-brachial index (ABI) 0.57 ± 0.11 and post-exercise ABI 0.40 ± 0.14 at baseline. After exercise training, there was no significant change in calf muscle capillarization, though walking capacity and peak oxygen uptake were increased significantly. The difference between the pre-and post-training capillaries in contact with type IIx and IIa muscle fibers for each subject was significantly correlated with an improved pain-free walking time, r=0.69 and r=0.62 (both p<0.05), respectively. This finding suggests that the change in calf muscle capillarization might contribute to improved walking capacity following exercise training in subjects with intermittent claudication.

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A Pilot Exercise Intervention to Improve Lower Extremity Functioning in Peripheral Arterial Disease Unaccompanied by Intermittent Claudication

Cited by 37 publications

References 34 publications

Upper- versus lower-limb aerobic exercise training on health-related quality of life in patients with symptomatic peripheral arterial disease

Upper- versus lower-limb aerobic exercise training on health-related quality of life in patients with symptomatic peripheral arterial disease

Persistent Depressive Symptoms and Functional Decline Among Patients With Peripheral Arterial Disease

Effects of Supervised Treadmill Walking Training on Calf Muscle Capillarization in Patients with Intermittent Claudication

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