A Pilot Clinical Study of Short-Term Isoflavone Supplements in Breast Cancer Patients

Sartippour, Maryam R.; Rao, Jian Yu; Apple, Sophia K.; Wu, Debbie; Henning, Susanne M.; Wang, He-Jing; Elashoff, Robert M.; Rubio, Rosalio; Heber, David; Brooks, Mai N.

doi:10.1207/s15327914nc4901_8

Cited by 55 publications

(40 citation statements)

References 19 publications

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“…De récentes études ont montré que ni les protéines de soja, ni les aliments au soja, ni les compléments alimentaires d'isoflavones n'ont d'effet sur des marqueurs du risque de cancer du sein comme la densité mammographique (Hooper, 2010 ;Wu, 2015) ou la prolifération des cellules mammaires (Khan et al, 2012 ;Palomares, 2004 ;Sartippour, 2004 ;Shike, 2014).…”

Section: En Cas D'antécédents De Cancer Du Seinunclassified

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Chevalier¹,

Debeuf²,

Joubrel³

et al. 2016

OCL

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Résumé -Aujourd'hui, 4 Français sur 10 consomment des aliments au soja. Les consommateurs les ont intégrés dans leur alimentation, sans bouleverser leurs habitudes alimentaires, parce qu'ils les considèrent naturels et sains. Les non consommateurs sont en attente de plus d'informations (origine géographique du soja et qualités nutritionnelles). La consommation est assez récente et devrait progresser dans les prochaines années. Les aliments élaborés à partir de la graine de soja fournissent des protéines de très bonne qualité nutritionnelle, des acides gras insaturés, des fibres, des vitamines et des minéraux. La graine de soja contient des isoflavones, dont une grande partie est éliminée lors de l'élaboration des aliments au soja (qui en contiennent 1 à 3 mg/g de protéine). La consommation actuelle d'aliments au soja est largement compatible avec l'apport maximal de 1mg/kg/j recommandé par l'Afssa en 2005. Le développement infantile avec les préparations à base de protéines de soja est comparable à celui observé avec celles à base de protéines de lait de vache ou avec le lait maternel, sur tous les paramètres étudiés (croissance, santé osseuse et fonctions métaboliques, reproductives, endocrines, immunitaires et neurologiques). Les aliments au soja semblent exercer un effet protecteur vis-à-vis du risque de cancer du sein (probablement lié aux isoflavones), surtout si la consommation est débutée avant l'adolescence. Chez les femmes ayant des antécédents de cancer du sein, l'alimentation peut intégrer les aliments au soja. Introduire des aliments à base de soja dans l'alimentation contribue aussi à maintenir la santé cardiovasculaire, du fait de leur effet favorable sur le taux de LDL-cholestérol, sur la fonction endothéliale, et potentiellement sur la tension artérielle. Mots clés :Alimentation / soja / consommation / nutrition / santé Abstract -Soyfoods: consumption in France, nutritional qualities and recent scientific data on its contribution to health. Today, 4 French people out of 10 eat soyfoods. Consumers have adopted them in their diet, without changing their habits, because they consider them natural and healthy. The non-users are waiting for more information (geographical origin, nutritional benefits). The consumption is relatively new and is expected to grow in the coming years. Soyfoods produced from soybeans provide high quality proteins, unsaturated fatty acids, fibres, vitamins and minerals. Soybeans contain isoflavones, much of which is lost during the production of soyfoods, which contain between 1 and 3 mg per g protein. The current consumption of soyfoods is largely consistent with the maximum intake of 1 mg/kg/day recommended by the Afssa in 2005. Infant development with formulas based on soy protein is similar to that observed with those based on cow milk or with breast milk, on all studied parameters (growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions). Soyfoods may have a protective effect against the risk for breast cancer (probably due to isofla...

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Section: En Cas D'antécédents De Cancer Du Seinunclassified

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Chevalier¹,

Debeuf²,

Joubrel³

et al. 2016

OCL

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“…41 One study found that supplementation with 200 mg of soy isoflavones daily over two to six weeks before breast cancer surgery showed a nonsignificant trend toward inhibition of cancer growth compared with a control group. 43 A meta-analysis of five prospective cohort studies from the United States and China found that high consumption of soy protein or soy isoflavones after breast cancer diagnosis was associated with a 26% decrease in recurrence (HR 0.74, 95% CI 0.61-0.85) and a 16% reduction in breast cancer mortality (HR 0.84, 95% CI 0.71-0.99) compared with low consumption. 44 Another meta-analysis of four prospective cohort studies, two of which were included in the previous analysis, found a 16% reduced risk of recurrence among women consuming high levels of soy isoflavone (RR 0.84, 95% CI 0.65-0.86), with no significant heterogeneity among the studies.…”

Section: Soymentioning

confidence: 99%

Lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health

Hamer

Warner

2017

CMAJ

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A lthough more than 90% of patients with breast cancer have early stage disease at diagnosis, about 25% will eventually die of distant metastasis.1 Many patients with breast cancer seek information from a variety of sources about behaviours that may reduce their risk of recurrence.2 Making positive lifestyle changes can also be psychologically beneficial to patients by empowering them, since the feeling of loss of control is one of biggest challenges of a cancer diagnosis.In this review, we identify which lifestyle changes can be recommended to patients as an adjunct to standard breast cancer treatments, to reduce their risk of distant recurrence and death. We review the role of lifestyle factors, particularly weight management, exercise, diet, smoking, alcohol intake and vitamin supplementation, on the prognosis of patients with breast cancer. Our literature search is summarized in Box 1.It is challenging to study lifestyle factors independently, because patients who are more physically active often are leaner, eat a healthier diet and are typically less likely to drink excessive amounts of alcohol or smoke; however, many studies try to adjust for these confounders.3 Another limitation is the potential impact of lifestyle factors before diagnosis. 4 Regrettably, but understandably, we found very few randomized trials. How does body weight influence the prognosis for breast cancer?Women who gain weight during or after treatment of breast cancer have been consistently shown to be at higher risk of breast cancer-related death.5-7 Also, women who are overweight or obese at the time of diagnosis have a poorer prognosis.8 Proposed mechanisms of how obesity might affect breast cancer mortality include a rise in circulating insulin-like growth factor, elevated circulating sex hormones and production of proinflammatory cytokines.9-12 Another possible mechanism is metabolic syndrome (presence of at least three of the following five components: abdominal obesity, hypertension, low level of highdensity lipoproteins, high plasma glucose level and high triglyceride levels). 13 In a recent study involving early stage breast cancer survivors, patients with metabolic syndrome were at significantly increased risk of distant metastasis (hazard ratio [HR] 2.45, 95% confidence interval [CI] 1.24-4.82) compared with those without the syndrome. 13Most patients with breast cancer gain weight both during and after active treatment, and much of the weight is never lost. The average reported weight gain is 2.5-5 kg, 5 but a gain of 10 kg or more is not uncommon.14 The reasons for weight gain are multifactorial and include "stress eating," reduced activity because of fatigue or other treatment-related adverse effects, lowered metabolic rate from chemotherapy, and use of pre-and post-chemotherapy medications such as dexamethasone.14 Weight gain is most common in women who experience treatment-related menopause and is often accompanied by relative fat gain and muscle loss. 15Several observational studies have shown that gaining weight dur...

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“…Around the globe federal and government efforts have accumulated on consensus for statutory policy to use nutraceuticals on their daily requirements, supplementation, combinations and dosage to prevent or manage the cancer [79][80][81][82][83]. Randomized and double blind control trials indicated the increased importance of vitamins, herbs and fresh vegetables as likely protective supplements [84][85][86][87][88][89][90], tomato (lycopene) in prostate cancer prevention [91][92][93], nutritional intervention in different cancers of different body organs in the body [94][95][96][97][98][99][100]. New concept of Mediterranean diet was introduced to reduce the risk of cancer along with cardioprotection [101][102][103][104].…”

Section: Nutraceuticals In Cancer Prevention During Years 2002-2008mentioning

confidence: 99%

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

Sharma¹

2009

TONUTRAJ

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Nutraceuticals are natural and bioactive products with food value to keep energy balance in the body and promise substantial therapeutic value in several diseases. Major nutraceuticals are now part of nutrition supplements at nonprescription counters and their self-prescription is increased at large scale. The current literature suggests the nutraceutical use in most of cancer prevention and management. The biochemical mechanism of nutraceuticals is poorly reported and most of the literature indicates the success of nutaceuticals in experimental animals. Broadly nutraceuticals are antioxidants, omega-3 fatty acids, vitamins, minerals and dietary fibers. Most of the nutraceuticals are derived from plants and animal origin and act as biochemical metabolites either by direct intermediary metabolism or regulating immunity.

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A Pilot Clinical Study of Short-Term Isoflavone Supplements in Breast Cancer Patients

Cited by 55 publications

References 19 publications

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé

Lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

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