A Piezoelectric Immunosensor Based on Magnetic Carbon Nanocomposites for the Determination of Ciprofloxacin

Bizina, E. V.; Farafonova, O. V.; Zolotareva, N. I.; Grazhulene, S. S.; Ermolaeva, T. N.

doi:10.1134/s1061934822040049

Cited by 14 publications

(4 citation statements)

References 24 publications

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“…Introducing piezoelectricity into this concept, the composite was then used as the recognition layer for a novel piezoelectric immunosensor. The result of this creative approach was the sensitive and selective determination of ciprofloxacin in various food products with a LOD of 2 ng/mL for MCNC1 and 8 ng/mL for MCNC2 [100]. Furthermore, Bizina and colleagues reported that the linear range of the developed sensor was reported to be 5-400 ng/mL [100].…”

Section: Immunosensors Used For Quinolone Detectionmentioning

confidence: 99%

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Recent Trends in Biosensors for Quinolone Detection: A Comprehensive Review

Thurner,

Alatraktchi

2023

Chemosensors

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Quinolones represent a vast family of antibiotics used extensively around the globe in human and veterinary medicine. Over the past decade, the field of biosensors for quinolone detection has experienced significant growth, thanks to the advancements in nanotechnology. These biosensors have emerged as a promising tool for fast and accurate point-of-care detection of quinolones. Although research efforts have proven that it is possible to detect quinolones in complex matrices and in relevant concentration ranges, the complexity of the sensor functionalization and the risk of limited reproducibility has hindered the transfer to real-life applications. This review holistically summarizes existing electrochemical quinolone sensors in comparison to optical and piezoelectric sensors and discusses the challenges that remain to be solved.

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Section: Immunosensors Used For Quinolone Detectionmentioning

confidence: 99%

“…Bizina and colleagues managed to merge carbon nanotubes with magnetic nanoparticles (Fe 3 O 4 NPs) to form two kinds of magnetic carbon composites (MCNC1/2) [100]. Introducing piezoelectricity into this concept, the composite was then used as the recognition layer for a novel piezoelectric immunosensor.…”

Section: Immunosensors Used For Quinolone Detectionmentioning

confidence: 99%

Recent Trends in Biosensors for Quinolone Detection: A Comprehensive Review

Thurner,

Alatraktchi

2023

Chemosensors

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“…The immunosensor achieved the LOD of 9 ng mL −1 and 8 ng mL −1 for levofloxacin (LEV) and CIP, respectively. Similarly, Bizina et al ( 2022 ) developed a piezoelectric immunosensor with a recognition layer based on magnetic carbon nanocomposites for CIP detection in milk and meat sample. The receptor coating of the sensor was formed by the action of magnetic field on magnetic particles located on the surface of CNTs modified with a CIP conjugate.…”

Section: Electrochemical Biosensors For Fqsmentioning

confidence: 99%

Functionalities of electrochemical fluoroquinolone sensors and biosensors

Nepfumbada,

Mthombeni,

Sigwadi

et al. 2023

Environ Sci Pollut Res

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Fluoroquinolones (FQs) are a class of broad-spectrum antimicrobial agents that are used to treat variety of infectious diseases. This class of antibiotics was being used for patients exhibiting early symptoms of a human respiratory disease known as the COVID-19 virus. As a result, this outbreak causes an increase in drug-resistant strains and environmental pollution, both of which pose serious threats to biota and human health. Thus, to ensure public health and prevent antimicrobial resistance, it is crucial to develop effective detection methods for FQs determination in water bodies even at trace levels. Due to their characteristics like specificity, selectivity, sensitivity, and low detection limits, electrochemical biosensors are promising future platforms for quick and on-site monitoring of FQs residues in a variety of samples when compared to conventional detection techniques. Despite their excellent properties, biosensor stability continues to be a problem even today. However, the integration of nanomaterials (NMs) could improve biocompatibility, stability, sensitivity, and speed of response in biosensors. This review concentrated on recent developments and contemporary methods in FQs biosensors. Furthermore, a variety of modification materials on the electrode surface are discussed. We also pay more attention to the practical applications of electrochemical biosensors for FQs detection. In addition, the existing challenges, outlook, and promising future perspectives in this field have been proposed. We hope that this review can serve as a bedrock for future researchers and provide new ideas for the development of electrochemical biosensors for antibiotics detection in the future.

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“…Для определения содержания лекарственных соединений в биологических объектах требуются высокочувствительные, селективные и несложные методы. Такими преимуществами обладают пьезоэлектрические [5,6] и электрохимические иммуносенсоры [7,8] [9 -13]. Для более эффективного закрепления на поверхности трансдьюсеров модификаторы наносят совместно с гиперразветвленными структурами (полиэфирополиолы) или дендримерами [14].…”

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Amperometric Immunosensors Based on Carbon Nanomaterials and Rhenium Clusters for the Determination of Tricyclic Antidepressants in a Sequential Injection System

Medyantseva¹,

Gazizullina²,

Брусницын³

et al. 2022

АиК

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A method of sequential injection determination of tricyclic antidepressants (amitriptyline, desipramine, imipramine) using amperometric immunosensors based on screen-printed graphite electrodes modified by carbon nanomaterials (carbon nanotubes, graphene oxide or fullerene) in combination with hexarhenium chalcogenide clusters is proposed. Sequential injection analysis was performed at a sweep rate of 10 mV/s; the flow rate (supporting electrolyte – phosphate buffer solution with pH 7.0) was also varied from 20 to 40 µl/s. Composition of the modifier affects the analytical capability of immunosensors. Screening of various types of modifiers showed that the immunosensor based on graphene oxide and cyanide complexes of rhenium chalcogenide clusters exhibited the highest sensitivity of 23.9±0.9 with a range of working concentrations of 1·10–10–1·10–5 M, and even wider range of detectable concentrations, 1·10–10–1·10–4 M was observed for the immunosensor based on fullerene and cyanide complexes of rhenium chalcogenide clusters. The lowest limit of the determined contents was (4–7)·10–11 M. Relative standard deviation of repeatability (Sr) did not exceed 0.046. The results obtained show that the proposed immunosensors can be used in sequential injection determination of trace amounts of medicinal compounds (antidepressants) in biomedical objects.

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A Piezoelectric Immunosensor Based on Magnetic Carbon Nanocomposites for the Determination of Ciprofloxacin

Cited by 14 publications

References 24 publications

Recent Trends in Biosensors for Quinolone Detection: A Comprehensive Review

Recent Trends in Biosensors for Quinolone Detection: A Comprehensive Review

Functionalities of electrochemical fluoroquinolone sensors and biosensors

Amperometric Immunosensors Based on Carbon Nanomaterials and Rhenium Clusters for the Determination of Tricyclic Antidepressants in a Sequential Injection System

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