Purpose: Aim of the present study is to report two possible scenarios, one optimistic and one cautelative, on ART activity in Italy and Lombardy County after the COVID-19 lockdown. Methods: Based on historical data from the ART Italian National Register in general and Lombardy County in particular, we derived two ipothesis, on how the lockdown in Italy after Covid-19 epidemic, could affect the reduction in ART activity. The first one is considered a "cautelative" hypothesis and we modeled a substantial ART activity reduction. Results: In both proposed scenarios there is data evidencing a reduction in the number of cycles and of babies born. In the cautelative hypothesis there is a reduction of the number of cycles by 55% and in the optimistic one by 35.5%. The total National loss in babies born will be between 6,719 and 5,913 and in Lombardy between 2,093 and 1,256 according to the 2 different scenarios. Conclusions: The impact of Covid-19 epidemic on ART treatments will greatly reduce the number of babies born in the foreseable future. This not only to lockdown measures but also to reduced accessibility to treatments, even in a region like Lombardy carries out 30% of all the ART cycles in the country, mostly supported by public resources. Italian ART centres will face a great challenge in the management of the new policies for covid 19 containment. It will be difficult to find the right balance between maintaining enough available procedures, keeping both couples and staff safe.