A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Jing, Maofeng; Guo, Baodian; Li, Haiyang; Yang, Bo; Wang, Haonan; Kong, Guanghui; Zhao, Yao; Xu, Huawei; Wang, Yan; Ye, Wenwu; Dong, Suomeng; Qiao, Yongli; Tyler, Brett M.; Ma, Wenbo; Wang, Yuanchao

doi:10.1038/ncomms11685

Cited by 113 publications

(109 citation statements)

References 64 publications

(91 reference statements)

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“…'Protein Processing' is represented by proteins with molecular functions in 'Ubiquitination', 'Protein Folding/Stability', 'Protein Degradation' and 'Protein Sorting'. For example, the Phytophthora sojae effector PsAvh262 targets multiple soybean BiP family of chaperones and the Magnaporthe oryzae effector AvrPiz-t targets multiple E3 ligases (APIPs; Park et al, 2012;Jing et al, 2016;Park et al, 2016;Tang et al, 2017). In terms of molecular functions, while bacteria predominantly target 'Kinases' (32%), oomycete targets are more diverse in molecular function, including 'Oxidoreductases' (19%), 'Protein Folding/Stability' (17%) 'Phosphatases' (14%), or 'Promoters' (14%), with 'Kinases' only representing 2% of the total (Figure 4(d)).…”

Section: Oomycete and Fungal Effector Targets: Same But Differentmentioning

confidence: 99%

Oh, the places they'll go! A survey of phytopathogen effectors and their host targets

et al. 2017

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SUMMARYPhytopathogens translocate effector proteins into plant cells where they sabotage the host cellular machinery to promote infection. An individual pathogen can translocate numerous distinct effectors during the infection process to target an array of host macromolecules (proteins, metabolites, DNA, etc.) and manipulate them using a variety of enzymatic activities. In this review, we have surveyed the literature for effector targets and curated them to convey the range of functions carried out by phytopathogenic proteins inside host cells. In particular, we have curated the locations of effector targets, as well as their biological and molecular functions and compared these properties across diverse phytopathogens. This analysis validates previous observations about effector functions (e.g. immunosuppression), and also highlights some interesting features regarding effector specificity as well as functional diversification of phytopathogen virulence strategies.

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Section: Oomycete and Fungal Effector Targets: Same But Differentmentioning

confidence: 99%

Oh, the places they'll go! A survey of phytopathogen effectors and their host targets

et al. 2017

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“…For P. sojae, RNA-seq data were obtained at different stages of the life cycle including the mycelium, zoospore, and germinated cyst, as well as soybean roots (cultivar: Williams 82) at 3, 6, 12, 24 and 48 h after inoculation with P6497 zoospores, as previously described (Jing et al, 2016). Similarly, P. capsici RNA-seq data were obtained at various stages of the life cycle including the mycelium, sporangium, zoospore, and germinated cyst, as well as pepper roots (cultivar: EC01) at the indicated time points after inoculation with JX1 zoospores (W. Cheng, unpublished).…”

Section: Rna-seq and Quantitative Real-time Pcrmentioning

confidence: 99%

Chitin synthase is involved in vegetative growth, asexual reproduction and pathogenesis of Phytophthora capsici and Phytophthora sojae

Wei

Lin

et al. 2019

Environmental Microbiology

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Summary Chitin is a structural and functional component of the fungal cell wall and also serves as a pathogen‐associated molecular pattern (PAMP) that triggers the innate immune responses of host plants. However, no or very little chitin is found in the fungus‐like oomycetes. In Phytophthora spp., the presence of chitin has not been demonstrated so far, although putative chitin synthase (CHS) genes, which encode the enzymes that synthesize chitin, are present in their genomes. Here, we revealed that chitin is present in the zoospores and released sporangia of Phytophthora, and this is most consistent with the transcriptional pattern of PcCHS in Phytophthora capsici and PsCHS1 in Phytophthora sojae. Disruption of the CHS genes indicated that PcCHS and PsCHS1, but not PsCHS2 (which exhibited very weak transcription), have similar functions involved in mycelial growth, sporangial production, zoospore release and the pathogenesis of P. capsici and P. sojae. We also suggest that chitin in the zoospores of P. capsici can act as a PAMP that is recognized by the chitin receptors AtLYK5 or AtCERK1 of Arabidopsis. These results provide new insights into the biological significance of chitin and CHSs in Phytophthora and help with the identification of potential targets for disease control.

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“…Interfering with the stability of target proteins or crucial immune components is commonly used by pathogen effectors. For instance, the P. sojae RxLR effector PsAvh262 targets and stabilizes BiPs (binding immunoglobulin proteins) to suppress ER stress‐mediated immunity and facilitate infection (Jing et al , ). The Xanthomonas oryzae pv.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the P. sojae RxLR effector PsAvh262 targets and stabilizes BiPs (binding immunoglobulin proteins) to suppress ER stress-mediated immunity and facilitate infection (Jing et al, 2016). The Xanthomonas oryzae pv.…”

Section: Pcavh103 Can Disrupt Eds1-pad4 Associationmentioning

confidence: 99%

A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1

Wang

Bai

et al. 2020

Molecular Plant Pathology

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EDS1 (Enhanced Disease Susceptibility 1) plays a crucial role in both effector‐triggered immunity activation and plant basal defence. However, whether pathogen effectors can target EDS1 or an EDS1‐related pathway to manipulate immunity is rarely reported. In this study, we identified a Phytophthora capsici Avirulence Homolog (Avh) RxLR (Arg‐any amino acid‐Leu‐Arg) effector PcAvh103 that interacts with EDS1. We demonstrated that PcAvh103 can facilitate P. capsici infection and is required for pathogen virulence. Furthermore, genetic evidence showed that PcAvh103 contributes to virulence through targeting EDS1. Finally, PcAvh103 specifically interacts with the lipase domain of EDS1 and can promote the disassociation of EDS1–PAD4 (Phytoalexin Deficient 4) complex in planta. Together, our results revealed that the P. capsici RxLR effector PcAvh103 targets host EDS1 to suppress plant immunity, probably through disrupting the EDS1–PAD4 immune signalling pathway.

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A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Cited by 113 publications

References 64 publications

Oh, the places they'll go! A survey of phytopathogen effectors and their host targets

Oh, the places they'll go! A survey of phytopathogen effectors and their host targets

Chitin synthase is involved in vegetative growth, asexual reproduction and pathogenesis of Phytophthora capsici and Phytophthora sojae

A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1

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