A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering

Calejo, Isabel; Costa‐Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.

doi:10.1016/j.tibtech.2019.06.003

Cited by 37 publications

(49 citation statements)

References 88 publications

(104 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar gradients have been produced for osteochondral tissue engineering 206 , an interesting yet challenging approach to the creation of life-like interfaces. Nevertheless, materials with 3D gradients in mechanical characteristics are still scarcely reported in the literature, and it will be interesting to see what the future holds with regard to this approach to interface tissue fabrication, as scientists begin to develop the toolbox for soft-to-hard tissue bioengineering 207 .…”

Section: [H2] Mechanical Stimulationmentioning

confidence: 99%

The stiffness of living tissues and its implications for tissue engineering

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: [H2] Mechanical Stimulationmentioning

confidence: 99%

The stiffness of living tissues and its implications for tissue engineering

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…These architectural features significantly contribute to normal tissue functions. [ 147 ] Failing to deliver or recover these anisotropic properties can lead to scar formation and tissue degeneration; while even only partially recapitulating these topographical characteristics has been shown to optimize the bio‐integration of implanted materials and enhanced regeneration outcome. [ 148 ]…”

Section: Design Principles Of Tissue Adhesivesmentioning

confidence: 99%

Multifaceted Design and Emerging Applications of Tissue Adhesives

2021

View full text Add to dashboard Cite

Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in a variety of medical settings such as wound closure, surgical sealants, regenerative medicine, and device attachment. The advantages of tissue adhesives include ease of implementation, rapid application, mitigation of tissue damage, and compatibility with minimally invasive procedures. The field of tissue adhesives is rapidly evolving, leading to tissue adhesives with superior mechanical properties and advanced functionality. Such adhesives enable new applications ranging from mobile health to cancer treatment. To provide guidelines for the rational design of tissue adhesives, here, existing strategies for tissue adhesives are synthesized into a multifaceted design, which comprises three design elements: the tissue, the adhesive surface, and the adhesive matrix. The mechanical, chemical, and biological considerations associated with each design element are reviewed. Throughout the report, the limitations of existing tissue adhesives and immediate opportunities for improvement are discussed. The recent progress of tissue adhesives in topical and implantable applications is highlighted, and then future directions toward next‐generation tissue adhesives are outlined. The development of tissue adhesives will fuse disciplines and make broad impacts in engineering and medicine.

show abstract

“…Even though several attempts to regenerate entheses have repeatedly been carried out in recent years, there is still no complete and functional solution to recreate their complexity in function and structure. The challenges of enthesis tissue engineering were also reviewed elsewhere, examples of recent review articles are [ 1 , 5 , 30 , 36 , 37 , 53 ]. As described above, the development of entheses during embryonic development is very extensive and influenced by many factors.…”

Section: Approaches Towards Restoration or Regeneration Of A Damagmentioning

confidence: 99%

Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor

Friese

Gierschner

Schadzek

et al. 2020

IJMS

View full text Add to dashboard Cite

Musculoskeletal dysfunctions are highly prevalent due to increasing life expectancy. Consequently, novel solutions to optimize treatment of patients are required. The current major research focus is to develop innovative concepts for single tissues. However, interest is also emerging to generate applications for tissue transitions where highly divergent properties need to work together, as in bone-cartilage or bone-tendon transitions. Finding medical solutions for dysfunctions of such tissue transitions presents an added challenge, both in research and in clinics. This review aims to provide an overview of the anatomical structure of healthy adult entheses and their development during embryogenesis. Subsequently, important scientific progress in restoration of damaged entheses is presented. With respect to enthesis dysfunction, the review further focuses on inflammation. Although molecular, cellular and tissue mechanisms during inflammation are well understood, tissue regeneration in context of inflammation still presents an unmet clinical need and goes along with unresolved biological questions. Furthermore, this review gives particular attention to the potential role of a signaling mediator protein, transforming growth factor beta-activated kinase-1 (TAK1), which is at the node of regenerative and inflammatory signaling and is one example for a less regarded aspect and potential important link between tissue regeneration and inflammation.

show abstract

A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering

Cited by 37 publications

References 88 publications

The stiffness of living tissues and its implications for tissue engineering

The stiffness of living tissues and its implications for tissue engineering

Multifaceted Design and Emerging Applications of Tissue Adhesives

Regeneration of Damaged Tendon-Bone Junctions (Entheses)—TAK1 as a Potential Node Factor

Contact Info

Product

Resources

About