A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling

Peterson, Mark; Riggs, Matthew M.

doi:10.1016/j.bone.2009.08.053

Cited by 164 publications

(225 citation statements)

References 60 publications

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“…Since MATLAB (Mathwork TM , Natick, MA, USA) is suitable for solving differential equations and enables easy coding due to internal functions and useful toolboxes, it was used to solve the model for the short-term dynamics of PTH in response to acute changes in serum Ca (Shrestha et al, 2010). Furthermore, alternative software developed for solving large-scale differential equations such as Berkeley Madonna, developed at the University of California at Berkeley, and Hummod (Biological Simulators, Inc.) for physiological models are available (Peterson and Riggs, 2010;Raposo et al, 2002).…”

Section: (Equation 4)mentioning

confidence: 99%

“…Another dynamic model was designed to predict changes in serum Ca in response to PTH action caused by citrate infusion, mimicking perturbations in space flight . The short-term dynamics of PTH in response to acute changes in serum Ca (Shrestha et al, 2010), and a physiology-based model integrating Ca homeostasis and bone remodeling (Peterson and Riggs, 2010) have also been reported. Recently, modeling to simulate Ca dynamics as a result of system perturbations has been used to aid in the design and interpretation of studies (Lee et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Review of Ca Metabolic Studies and a Model for Optimizing Gastrointestinal Ca Absorption and Peak Bone Mass in Adolescents

Park

Cho

Lee

2015

Journal of Biosystems Engineering

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Purpose:The objective of this study is to review researches regarding factors that potentially affect adolescent calcium (Ca) metabolism, and to suggest a potential modeling approach for optimizing gastrointestinal Ca absorption and peak bone mass. Background: Optimal gastrointestinal Ca absorption is a key to maximizing peak bone mass in adolescents. Urine Ca excretion in adolescents rises only after bone accretion is saturated, indicating that higher intestinal Ca absorption and bone retention is necessary to ensure maximum bone accretion. Hence, maximizing peak bone mass is possible by controlling the factors influencing gastrointestinal Ca absorption and bone accretion. However, a mechanism that explains the unique adolescent Ca metabolism has not yet been elucidated. Review: Dietary factors that enhance gastrointestinal Ca absorption may increase the available Ca pool usable for bone accretion, and a specific hormone may direct optimal Ca utilization to maximize peak bone mass. IGF-1 is an endocrine hormone whose levels peak during adolescence and increase fractional Ca absorption and bone Ca accretion. Prebiotics, generally obtained from dietary sources, have been reported to exert a beneficial effect on Ca absorption via microbiota activity. We selected and reviewed three candidates that could be used to propose a comprehensive Ca metabolic model for optimal Ca absorption and peak bone mass in adolescents. Modeling: Modeling has been used to investigate Ca metabolism and its regulators. Herein, we reviewed previous Ca modeling studies. Based on this review, we proposed a method for developing a comprehensive model that includes regulatory effectors of IGF-1 and prebiotics.

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Section: (Equation 4)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review of Ca Metabolic Studies and a Model for Optimizing Gastrointestinal Ca Absorption and Peak Bone Mass in Adolescents

Park

Cho

Lee

2015

Journal of Biosystems Engineering

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“…This model was further used to examine 3 steps in active calcium absorption, i.e., Ca entry, facilitated diffusion and Ca extrusion, and showed enhanced Ca absorption by calbindinD 9K (Feher et al, 1992;Slepchenko and Bronner, 2001). Urine excretion has not been individually modeled, but only as a part of the calcium balance model (Hurwitz et al, 1987a;Peterson and Riggs, 2010;Raposo et al, 2002). The bone remodeling process has been modeled as a function of bone cells and their regulators (Komarova, 2005;Komarova et al, 2003;Kroll, 2000;Lemaire et al, 2004;Rattanakul et al, 2003).…”

Section: Mechanistic Modeling In Calcium Studiesmentioning

confidence: 99%

“…In contrast to the bone cell models, bone mineralization was modeled as a function of mineral transport, diffusion and precipitation (Martin, 1994). However, few studies have linked calcium deposition/ resorption into bone with bone cell activity (Peterson and Riggs, 2010).…”

Section: Mechanistic Modeling In Calcium Studiesmentioning

confidence: 99%

“…Mechanism-based pharmacokinetics and pharmacodynamics (PK/PD) were used to model the PTH-regulated calcium homeostasis in rats and humans (Abraham et al, 2009). Most recently, a complete model that links calcium homeostasis and bone remodeling has been presented (Peterson and Riggs, 2010). As shown in the above models, mechanistic modeling is a powerful tool to investigate the mechanism of the dynamic response in calcium metabolism.…”

Section: Mechanistic Modeling In Calcium Studiesmentioning

confidence: 99%

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Review on Application of Biosystem Modeling: Introducing 3 Model-based Approaches in Studying Ca Metabolism

Lee

Cho²

2012

Journal of Biosystems Engineering

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Purpose:This review aims at introducing 3 modeling approaches classified into 3 categories based on the purpose (estimation or prediction), structure (linear or non-linear) and phase (steady-state or dynamic-state); 1) statistical approaches, 2) kinetic modeling and 3) mechanistic modeling. We hope that this review can be a useful guide in the model-based approach of calcium metabolism as well as illustrates an application of engineering tools in studying biosystems. Background: The meaning of biosystems has been expanded, including agricultural/food system as well as biological systems like genes, cells and metabolisms. This expansion has required a useful tool for assessing the biosystems and modeling has arisen as a method that satisfies the current inquiry. To suit for the flow of the era, examining the system which is a little bit far from the traditional biosystems may be interesting issue, which can enlarge our insights and provide new ideas for prospective biosystem-researches. Herein, calcium metabolic models reviewed as an example of application of modeling approaches into the biosystems. Review: Calcium is an essential nutrient widely involved in animal and human metabolism including bone mineralization and signaling pathways. For this reason, the calcium metabolic system has been studied in various research fields of academia and industries. To study calcium metabolism, model-based system analyses have been utilized according to the purpose, subject characteristics, metabolic sites of interest, and experimental design. Either individual metabolic pathways or a whole homeostasis has been modeled in a number of studies.

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Physics‐Based Modeling for the Physiome

Pruett

Hester

2016

The Digital Patient

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A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling

Cited by 164 publications

References 60 publications

Review of Ca Metabolic Studies and a Model for Optimizing Gastrointestinal Ca Absorption and Peak Bone Mass in Adolescents

Review of Ca Metabolic Studies and a Model for Optimizing Gastrointestinal Ca Absorption and Peak Bone Mass in Adolescents

Review on Application of Biosystem Modeling: Introducing 3 Model-based Approaches in Studying Ca Metabolism

Physics‐Based Modeling for the Physiome

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