A physico-chemical and biological study of novel chitosan–chloroquinoline derivative for biomedical applications

Kumar, Santosh; Dutta, Pradip Kumar; Koh, Joonseok

doi:10.1016/j.ijbiomac.2011.05.017

Cited by 82 publications

(54 citation statements)

References 47 publications

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“…The medium intensity peak at 1414 cm -1 corresponding to O-H bending confirms the existence of this O-H functional group. The weak intensity band at 2879 cm -1 corresponds to C-H stretch [27]. Peaks at 1633, at 1537 and at 1383 cm -1 are assigned to -C=O amide, -NH 2 , and -NHCO amide, respectively [28,29].…”

Section: Chemical Resistibilitymentioning

confidence: 99%

Acidic pH resistance of grafted chitosan on dental implant

et al. 2014

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Over the last decade, access to dental care has increasingly become a service requested by the population, especially in the case of dental implants. However, the major cause of implant failure is an inflammatory disease: peri-implantitis. Currently, the adhesion strength of antibacterial coatings at implant surfaces remains a problem to solve. In order to propose a functionalized implant with a resistant antibacterial coating, a novel method of chitosan immobilization at implant surface has been investigated. Functionalization of the pre-active titanium (Ti) surface was performed using triethoxysilylpropyl succinic anhydride (TESPSA) as a coupling agent which forms a stable double peptide bond with chitosan. The chitosan presence and the chemical resistibility of the coating under acid pH solutions (pH 5 and pH 3) were confirmed by FTIR-ATR and XPS analyses. Furthermore, peel test results showed high adhesive resistance of the TESPSA/chitosan coating at the substrate. Cytocompatibility was evaluated by cell morphology with confocal imaging. Images showed healthy morphology of human gingival fibroblasts (HGF-1). Finally, the reported method for chitosan immobilization on Ti surface via peptide bindings allows for the improvement of its adhesive capacities and resistibility while maintaining its cytocompatibility. Surface functionalization using the TESPSA/chitosan coupling method is noncytotoxic and stable even in drastic environments as found in oral cavity, thus making it a valuable candidate for clinical implantology applications.

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Section: Chemical Resistibilitymentioning

confidence: 99%

Acidic pH resistance of grafted chitosan on dental implant

et al. 2014

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“…This polymer is still being modified to produce various derivatives with improved properties. We have recently demonstrated that chitosan-chloroquinoline conjugate has also potent antimicrobial activity [19]. Several previous studies have synthesized various thymine derivatives and reported potent anti-cancer effect [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A new chitosan–thymine conjugate: Synthesis, characterization and biological activity

Kumar

Koh

Kim

et al. 2012

International Journal of Biological Macromolecules

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“…Crosslinkers are molecules with at least two reactive functional groups that allow the formation of bridges between polymeric chains [15]. Various methods have been developed for the cross-linking of chitosan biopolymer, which result in gel formation [16][17][18][19][20][21]. Cross-linking chitosan has been reported with small molecular dialdehydes, such as glyoxal and glutaraldehyde to create directly hydrogels [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…In continuation of our interest in the modification of chitosan with aldehyde, [3,20,21,30] and no previous report of chitosan-terephthaldehyde derivative, the present work is intended to the preparation and characterization of chitosan-terephthaldehyde (CS/TPAL) derivative and study of their rheological and optical properties.…”

Section: Introductionmentioning

confidence: 99%