A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing

Liu, Yingying; Sui, Yulong; Liu, Chao; Liu, Changqing; Wu, Meiyan; Li, Bin; Li, Youming

doi:10.1016/j.carbpol.2018.01.093

Cited by 269 publications

(127 citation statements)

References 36 publications

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“…[19] Hydrogel-based products can be prepared in a variety of different formulations, spanning a wide range of drug administration routes. [11,15,[20][21][22][23][24][25] One important feature of hydrogels is related to the possibility to develop controlled drug release devices. The term "controlled release" refers to the ability of a system to maintain the drug concentration at an optimal value in the target tissues over an extended period of time, avoiding under-and overdosing problems.…”

Section: Introductionmentioning

confidence: 99%

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Castiglione

Casalegno

Ferro

et al. 2019

Journal of Controlled Release

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Polymeric hydrogels are promising candidates for drug delivery applications, thanks to their ability to encapsulate, transport and release a wide range of chemicals. The successful application of these materials requires a deep understanding of the mechanisms governing solute transport at the nanoscale and its impact on release kinetics. In this work, we investigate the translational diffusion of ibuprofen loaded in anionic agarose-carbomer (AC) hydrogels by 1 H high resolution magic angle spinning (HR-MAS) NMR spectroscopy, and compare it to its macroscopic release kinetics. The analysis of the experimental NMR data provides the first evidence of superdiffusion for ibuprofen in AC hydrogels. Superdiffusive transport is observed in the majority of our samples, especially those with the smallest mesh size (7 nm) and highest ibuprofen concentrations (90-120 mg/mL). This outcome is rationalized in terms of heavy-tailed distributions of spatial displacements (Lèvy flights) and of waiting times, which depend on the nanoscopic structural heterogeneity of the gels and the strong but reversible association between ibuprofen and the agarose matrix.

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Section: Introductionmentioning

confidence: 99%

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Castiglione

Casalegno

Ferro

et al. 2019

Journal of Controlled Release

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“…These surface chemical modifications can increase the dispersibility of nanocellulose in organic solvents and their compatibility with the polymer matrix [ 68 ]. Chemical modifications also make it possible to directly attach nanoparticles directly to the polymer matrix by covalent bonding without the use of coupling agents or surfactants [ 69 , 70 , 71 ].…”

Section: Surface Modificationmentioning

confidence: 99%

Research Progress and Development Demand of Nanocellulose Reinforced Polymer Composites

Shen

Xue

et al. 2020

Polymers

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Nanocellulose is a type of nanomaterial with high strength, high specific surface area and high surface energy. Additionally, it is nontoxic, harmless, biocompatible and environmentally friendly and can be extracted from biomass resources. The surface groups of cellulose show high surface energy and binding activity on the nanoscale and can be modified by using various methods. Because nanocellulose has a high elastic modulus, rigidity and a low thermal expansion coefficient, it is an excellent material for polymer reinforcement. This paper summarizes the reinforcement mechanisms of nanocellulose polymer composites with a focus on the role of theoretical models in elucidating these mechanisms. Furthermore, the influence of various factors on the properties of nanocellulose reinforced polymer composites are discussed in combination with analyses and comparisons of specific research results in related fields. Finally, research focus and development directions for the design of high-performance nanocellulose reinforced polymer composites are proposed.

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“…Gao et al fabricated a novel imidacloprid microcapsule with PDA followed by polyurea (PU) exhibited excellent dispersion stability 27 . Undeniably, PDA is considered to be a promising pesticide encapsulant for obtaining novel controlled release formulation [28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

Fabrication a controlled-release pesticide for improving UV-shielding properties and reducing toxicity via coating polydopamine

Zhang

et al. 2020

Preprint

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In modern agriculture, controlled-release formulations (CRF) is greatly desirable for achieving valid utilization and loss reduction of pesticides. It can also alleviate the adverse effect on non-target organism. In this study, we used polydopamine (PDA) as a depositing layer, constructed pyraclostrobin@SiO 2 @polydopamine microcapsule (Pyr@SiO 2 @PDA MC). The resulting microcapsule is a near-rod shape (about 1.152μm), which has a drug-loading efficiency of 55%. FT-IR and TG analysis revealed the successful entrapment of the pesticide. The microencapsulation had important function in the slow-release rate of the pyraclostrobin and superior UV-shielding properties. Moreover, bioactivity of the microcapsule against Fusarium oxysporum f.sp.vasinfectum was determined and it exhibited better inhibition activity than pyraclostrobin technical in the later stage. At last, acute toxicity tests demonstrated that Pyr@SiO 2 @PDA MC on zebrafish with lower toxicity on the first day. These results showed that Pyr@SiO 2 @PDA MC may process broader application potential in agriculture.In modern agriculture, controlled-release formulations (CRF) is greatly desirable for achieving valid utilization and loss reduction of pesticides. It can also alleviate the adverse effect on non-target organism. In this study, we used polydopamine (PDA) as a depositing layer, constructed pyraclostrobin@SiO 2 @polydopamine microcapsule (Pyr@SiO 2 @PDA MC). The resulting microcapsule is a near-rod shape (about 1.152μm), which has a drug-loading efficiency of 55%. FT-IR and TG analysis revealed the successful entrapment of the pesticide. The microencapsulation had important function in the slow-release rate of the pyraclostrobin and superior UV-shielding properties. Moreover, bioactivity of the microcapsule against Fusarium oxysporum f.sp.vasinfectum was determined and it exhibited better inhibition activity than pyraclostrobin technical in the later stage. At last, acute toxicity tests demonstrated that Pyr@SiO 2 @PDA MC on zebrafish with lower toxicity on the first day. These results showed that Pyr@SiO 2 @PDA MC may process broader application potential in agriculture.

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A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing

Cited by 269 publications

References 36 publications

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Evidence of superdiffusive nanoscale motion in anionic polymeric hydrogels: Analysis of PGSE- NMR data and comparison with drug release properties

Research Progress and Development Demand of Nanocellulose Reinforced Polymer Composites

Fabrication a controlled-release pesticide for improving UV-shielding properties and reducing toxicity via coating polydopamine

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