A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings

Sanchez-Todo, Roser; Bastos, André M.; Lopez-Sola, Edmundo; Mercadal, Borja; Santarnecchi, Emiliano; Miller, Earl K.; Deco, Gustavo; Ruffini, Giulio

doi:10.1016/j.neuroimage.2023.119938

Cited by 8 publications

(5 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This distal influence, we suggest, creates an LFP power profile with a maximum alpha/beta power in deeper layers, creating the observed negative spatial correlation between alpha/beta LFP power and CR/CB cell body location. This proposal is consistent with biophysical modeling studies (Sanchez-Todo et al, 2023), as well as the observation of both superficial and deep generative sinks (Maier et al, 2011; van Kerkoerle et al, 2014) for alpha/beta oscillations.…”

Section: Discussionsupporting

confidence: 91%

“…This implies that one canonical function of the microcircuit is the generation of neuronal oscillations. These oscillations are thought to be generated by recurrent interactions between excitatory and inhibitory cells (Antonoudiou et al, 2020;Bartos et al, 2007;Carlén et al, 2012;Chen et al, 2017;Dupret et al, 2008;Mann Mody, 2010;Sanchez-Todo et al, 2023;Xu et al, 2016). The fact that there is a similar laminar organization of pyramidal cells and subtypes of inhibitory cells across layers provides a plausible explanation for the spectrolaminar motif, that is, a conserved functional pattern of stronger gamma (and theta) power in superficial layers and stronger alpha/beta power in the deep layers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The laminar organization of cell types in macaque cortex and its relationship to neuronal oscillations

Lichtenfeld,

Mulvey,

Nejat

et al. 2024

Preprint

View full text Add to dashboard Cite

The canonical microcircuit (CMC) has been hypothesized to be the fundamental unit of information processing in cortex. Each CMC unit is thought to be an interconnected column of neurons with specific connections between excitatory and inhibitory neurons across layers. Recently, we identified a conserved spectrolaminar motif of oscillatory activity across the primate cortex that may be the physiological consequence of the CMC. The spectrolaminar motif consists of local field potential (LFP) gamma-band power (40-150 Hz) peaking in superficial layers 2 and 3 and alpha/beta-band power (8-30 Hz) peaking in deep layers 5 and 6. Here, we investigate whether specific conserved cell types may produce the spectrolaminar motif. We collected laminar histological and electrophysiological data in 11 distinct cortical areas spanning the visual hierarchy: V1, V2, V3, V4, TEO, MT, MST, LIP, 8A/FEF, PMD, and LPFC (area 46), and anatomical data in DP and 7A. We stained representative slices for the three main inhibitory subtypes, Parvalbumin (PV), Calbindin (CB), and Calretinin (CR) positive neurons, as well as pyramidal cells marked with Neurogranin (NRGN). We found a conserved laminar structure of PV, CB, CR, and pyramidal cells. We also found a consistent relationship between the laminar distribution of inhibitory subtypes with power in the local field potential. PV interneuron density positively correlated with gamma (40-150 Hz) power. CR and CB density negatively correlated with alpha (8-12 Hz) and beta (13-30 Hz) oscillations. The conserved, layer- specific pattern of inhibition and excitation across layers is therefore likely the anatomical substrate of the spectrolaminar motif.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The laminar organization of cell types in macaque cortex and its relationship to neuronal oscillations

Lichtenfeld,

Mulvey,

Nejat

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Recent biophysical modeling, however, suggests an alternative interpretation: an alpha-beta power peak in deep layers in the LFP (referenced to the top of cortex), together with a superficial CSD power peak (as observed by previous studies 13 , 46 and in Extended Data Fig. 9 ), can both be modeled by considering the elongated cell bodies of deep-layer pyramidal neurons that receive synaptic inputs into apical dendrites in superficial layers as well as near the cell body in deep layers 47 , 48 . This modeling work suggests that the alpha-beta-generating circuitry includes both superficial and deep layers and is more spatially extended than the gamma-generating circuitry.…”

Section: Discussionmentioning

confidence: 78%

A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

Mendoza-Halliday,

Major,

Lee

et al. 2024

Nat Neurosci

Self Cite

View full text Add to dashboard Cite

The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity patterns exists across the cortex. Here we report such a motif in the power of local field potentials (LFPs). Using laminar probes, we recorded LFPs from 14 cortical areas across the cortical hierarchy in five macaque monkeys. The laminar locations of recordings were histologically identified by electrolytic lesions. Across all areas, we found a ubiquitous spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of high-frequency power peaking in layers 2/3 and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Laminar recordings from additional species showed that the spectrolaminar pattern is highly preserved among primates—macaque, marmoset and human—but more dissimilar in mouse. Our results suggest the existence of a canonical layer-based and frequency-based mechanism for cortical computation.

show abstract

“…Multielectrode data for MUA, CSD, and time-frequency analyses were centered around putative layer 4 based on the stimulus-triggered average responses to all stimuli. Criteria for alignment to layer 4 focused on i) the contact with the earliest MUA peak and current source/sink in the CSD (Niell and Stryker 2008;Ferro et al 2021) and ii) the more recently demonstrated shift from gamma to alpha/beta power spectra (which reflects supra-vs infra-granular layers; (Sanchez-Todo et al 2023)). This method also correlated well with the channel at which the LFP signals flipped polarity.…”

Section: Visual Stimulimentioning

confidence: 99%

Spatiotemporal dynamics across visual cortical laminae support a predictive coding framework for interpreting mismatch responses

Gallimore

Ricci

Hamm

2023

Preprint

View full text Add to dashboard Cite

Context modulates neocortical processing of sensory data. Unexpected visual stimuli elicit large responses in primary visual cortex (V1): a phenomenon known as deviance detection (DD) at the neural level, or mismatch negativity (MMN) when measured with EEG. It remains unclear how visual DD/MMN signals emerge across cortical layers, in temporal relation to the onset of deviant stimuli, and with respect to brain oscillations. Here we employed a visual oddball sequence (a classic paradigm for studying aberrant DD/MMN in neuropsychiatric populations) and recorded local field potentials in V1 of awake mice with 16-channel multielectrode arrays. Multiunit activity and current source density profiles showed that while basic adaptation to redundant stimuli was present early (50ms) in layer 4 responses, DD emerged later (150-230ms) in supragranular layers (L2/3). This DD signal coincided with increased delta/theta (2-7Hz) and high-gamma (70-80Hz) oscillations in L2/3 and decreased beta oscillations (26-36hz) in L1. These results clarify the neocortical dynamics elicited during an oddball paradigm at a microcircuit level. They are consistent with a predictive coding framework, which posits that predictive suppression is present in cortical feed-back circuits, which synapse in L1, while prediction errors engage cortical feed-forward processing streams, which emanate from L2/3.

show abstract

A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings

Cited by 8 publications

References 54 publications

The laminar organization of cell types in macaque cortex and its relationship to neuronal oscillations

The laminar organization of cell types in macaque cortex and its relationship to neuronal oscillations

A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

Spatiotemporal dynamics across visual cortical laminae support a predictive coding framework for interpreting mismatch responses

Contact Info

Product

Resources

About