2008
DOI: 10.1016/j.bone.2007.12.067
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A physical mechanism for coupling bone resorption and formation in adult human bone

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Cited by 40 publications
(74 citation statements)
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“…35 Furthermore, as angiogenesis is required for initiation and maintenance of osteoclastic bone resorption, its inhibition by cilengitide might have contributed to the observed decrease of osteolysis we observed after cilengitide treatment. 36 As cilengitide cross reacts with human and rat a v integrins, the observed effects in our study are because of the inhibition of a v b 3 and a v b 5 integrins on both, MDA-MB-231 and host cells in particular of the vascular and bone compartments. Which compartments are targeted to produce the effects we report here is under investigation.…”
Section: Cancer Therapymentioning
confidence: 53%
“…35 Furthermore, as angiogenesis is required for initiation and maintenance of osteoclastic bone resorption, its inhibition by cilengitide might have contributed to the observed decrease of osteolysis we observed after cilengitide treatment. 36 As cilengitide cross reacts with human and rat a v integrins, the observed effects in our study are because of the inhibition of a v b 3 and a v b 5 integrins on both, MDA-MB-231 and host cells in particular of the vascular and bone compartments. Which compartments are targeted to produce the effects we report here is under investigation.…”
Section: Cancer Therapymentioning
confidence: 53%
“…19). Native bone surfaces are coated with a mantle of fibrillar collagen (20)(21)(22), which is expressed, and in turn covered by bone-lining cells of the OB lineage (23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%
“…While the exact location of MSC in vivo is still debated, recent evidence suggests that some of these cells are pericytes located on the outer surface of blood vessels and sinusoids in the bone marrow (Sacchetti et al, 2007). Also, recent studies demonstrated the presence of a canopy of flat cells expressing osteoblastic markers covering active bone remodeling sites and associated with capillaries (Andersen et al, 2009), suggesting that osteoblastic cells may be recruited from a number of sources including pericytes and osteoprogenitor cells present in peripheral circulation or periosteum. Based on current understanding of the cellular events of bone formation phase of bone remodeling, several investigators have examined potential mechanisms causing age-related osteoblastic cell failure.…”
Section: Introductionmentioning
confidence: 99%