A physical map of the mouse genome

Gregory, Simon G.; Sekhon, Mandeep; Schein, Jacqueline E.; Zhao, Shaying; Osoegawa, Kazutoyo; Scott, Carol; Evans, Richard S.; Burridge, Paul W.; Cox, Tony; Fox, Christopher A; Hutton, Richard D.; Mullenger, Ian R; Phillips, K.; Smith, James; Stalker, Jim; Threadgold, Glen; Birney, Ewan; Wylie, Kristine M.; Chinwalla, Asif T.; Wallis, John W.; Hillier, LaDeana W.; Carter, Jason; Gaige, Tony; Jaeger, Sara R.; Kremitzki, Colin; Layman, Dan; Maas, Jason E.; McGrane, Rebecca; Mead, Kelly; Walker, R D; Jones, Steven J.M.; Smith, Michael W.; Asano, Jennifer; Bosdet, Ian; Chan, Susanna; Chittaranjan, Suganthi; Chiu, Readman; Fjell, C.; Fuhrmann, D.R.; Girn, Noreen; Gray, Catharine; Guin, Ran; Hsiao, Letticia; Krzywinski, Martin; Kutsche, Reta; Lee, Soo Sen; Mathewson, Carrie; McLeavy, Candice; Messervier, Steve; Ness, Steven R.; Pandoh, Pawan; Prabhu, Anna‐Liisa; Saeedi, Parvaneh; Smailus, Duane E.; Spence, Lorraine; Stott, Jeff; Taylor, Sheryl Sheeres; Terpstra, W.; Tsai, Miranda; Vardy, Jill; Wye, Natasja; Yang, George; Shatsman, S.; Ayodeji, Bola; Geer, Keita; Tsegaye, Getahun; Shvartsbeyn, Alla; Gebregeorgis, Elizabeth; Krol, Margaret; Russell, Daniel A.; Overton, Larry; Malek, Joel A.; Holmes, Michael W.R.; Heaney, Michael T.; Shetty, Jyoti; Feldblyum, Tamara; Nierman, William C.; Catanese, Joseph J.; Hubbard, Tim; Waterston, Robert H.; Rogers, Jane; Jong, Pieter J. de; Fraser, Claire M.; Marra, Marco A.; Mcpherson, John Douglas; Bentley, David

doi:10.1038/nature00957

Cited by 298 publications

(201 citation statements)

References 46 publications

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“…The coverage attained using these arrays corresponds to more than 96% of the euchromatic mouse genome, and no gaps exist that are greater than 100 kb except in gap regions in the current physical map (Gregory et al, 2002). In contrast to previous approaches to the genetic analysis of mouse tumors, which relied upon the presence of informative markers in crosses between different mouse strains, CGH arrays can be used for quantitative genome-wide analysis of tumors from completely inbred strains.…”

Section: Genome Covering Bac Microarraymentioning

confidence: 99%

Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice

Mao

Jiang

et al. 2005

Oncogene

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Section: Genome Covering Bac Microarraymentioning

confidence: 99%

Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice

Mao

Jiang

et al. 2005

Oncogene

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“…The new whole-genome BAC arrays (19 k arrays) consist of more than 19,200 BAC clones that form a virtually complete tiling path, except in regions without clone coverage in the present mouse physical map 2 . We applied the 19 k BAC arrays to detect chromosomal imbalances in mouse tumor samples from a 129/Sv background, using normal DNA from C57BL/6J mice as the control, and identified several regions that consistently showed copy-number losses or gains ( Fig.…”

mentioning

confidence: 99%

Genomic segmental polymorphisms in inbred mouse strains

Jiang

Mao

et al. 2004

Nat Genet

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“…The hybrid cells in which tumorigenicity was suppressed exhibited the elongated morphology of a normal mature fibrocyte and were embedded in a dense collagenous matrix; malignant segregants derived from these hybrids showed no evidence of an organized collagenous matrix (3). Scrutiny of the physical map of the mouse genome (4) revealed that the gene encoding procollagen XVa1 was located within the suppressive region identified by cytogenetic analysis. This was the only known gene in that region that had any obvious connection with a collagenous extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Complete Suppression of Tumor Formation by High Levels of Basement Membrane Collagen

Harris

Hollingsworth

2007

Molecular Cancer Research

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Suppression of tumorigenicity was first shown in hybrids produced by the fusion of a range of different highly malignant tumor cells with diploid fibroblasts. Cytogenetic analysis of these hybrids revealed that suppression involved a genetic region located in one specific chromosome donated to the hybrid cell by the fibroblast parent. The identity of the gene responsible for this dramatic effect has remained obscure. We now present strong evidence that the primary determinant is the gene specifying collagen XV, a proteoglycan closely associated with the basement membrane. We transfected a line of highly tumorigenic human cervical carcinoma cells with an expression vector carrying the full-length cDNA of the human collagen XV gene. We selected clones making various amounts of collagen XV, examined their growth in vitro, and tested their tumorigenicity in nude mice. High levels of collagen XV altered the growth properties of the cells in three-dimensional cultures. Moreover, we found that, in a dose-dependent manner, the production of collagen XV completely suppressed tumorigenicity in clones that synthesized this molecule at high levels. Immunohistologic studies suggest that suppression is associated with extracellular deposition of the proteoglycan at the cell periphery. (Mol Cancer Res 2007;5(12):1241 -5)

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A physical map of the mouse genome

Cited by 298 publications

References 46 publications

Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice

Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice

Genomic segmental polymorphisms in inbred mouse strains

Complete Suppression of Tumor Formation by High Levels of Basement Membrane Collagen

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