“…However, UBR4 does not contain a known E3 ligase motif, i.e., homology to E6AP-binding protein C-terminus (HECT) or RING domain (Tasaki et al, 2005), and its role as an E3 ligase for the degradation of STAT2 is still in question (Morrison and García-Sastre, 2014). Among other host proteins that can interact with NS5 of DENV, a member of human seven in absentia homolog, i.e., SIAH2, has also been reported forming interactions with NS5 (Le Breton et al, 2011;Khadka et al, 2011;Mairiang et al, 2013). SIAH2 protein is an E3 ligase and is involved in ubiquitination and proteosome-mediated degradation of specific proteins.…”