A photoresponsive recombinant human amelogenin‐loaded hyaluronic acid hydrogel promotes bone regeneration

Hsia, Tung‐Liang; Lin, Zhikai; Xia, Yiru; Shu, Rong; Xie, Yufeng

doi:10.1111/jre.13235

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…The hydrogel system designed by 2016) developed a pH-responsive hydrogel containing anti-glycation agents that slowed the progression of periodontitis and promoted recovery. Beyond environmentally sensitive hydrogels, there are also stimulus-responsive hydrogels and multisensitive hydrogels that offer combined advantages for drug delivery mechanisms, showing significant potential for future applications (Lin et al, 2020;Hsia et al, 2024).…”

Section: Hydrogels As Drug Delivery Systemsmentioning

confidence: 99%

Hydrogels promote periodontal regeneration

Sun,

Luan,

Dong

2024

Front. Bioeng. Biotechnol.

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Periodontal defects involve the damage and loss of periodontal tissue, primarily caused by periodontitis. This inflammatory disease, resulting from various factors, can lead to irreversible harm to the tissues supporting the teeth if not treated effectively, potentially resulting in tooth loss or loosening. Such outcomes significantly impact a patient’s facial appearance and their ability to eat and speak. Current clinical treatments for periodontitis, including surgery, root planing, and various types of curettage, as well as local antibiotic injections, aim to mitigate symptoms and halt disease progression. However, these methods fall short of fully restoring the original structure and functionality of the affected tissue, due to the complex and deep structure of periodontal pockets and the intricate nature of the supporting tissue. To overcome these limitations, numerous biomaterials have been explored for periodontal tissue regeneration, with hydrogels being particularly noteworthy. Hydrogels are favored in research for their exceptional absorption capacity, biodegradability, and tunable mechanical properties. They have shown promise as barrier membranes, scaffolds, carriers for cell transplantation and drug delivery systems in periodontal regeneration therapy. The review concludes by discussing the ongoing challenges and future prospects for hydrogel applications in periodontal treatment.

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Section: Hydrogels As Drug Delivery Systemsmentioning

confidence: 99%

Hydrogels promote periodontal regeneration

Sun,

Luan,

Dong

2024

Front. Bioeng. Biotechnol.

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Native vs. ribosome‐crosslinked collagen membranes for periodontal regeneration: A randomized clinical trial

Wang,

Xia,

Qian

et al. 2024

J of Periodontal Research

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AimTo evaluate whether the ribosome‐crosslinked collagen membrane (RCCM) is non‐inferior to the natural collagen membrane (NCM) used in regeneration surgery in terms of clinical attachment level (CAL) gain at 6 months.MethodsEighty patients diagnosed as generalized periodontitis presenting with isolated infrabony defect (≥4 mm deep) were enrolled and randomized to receive regenerative surgery, either with NCM or RCCM, both combined with deproteinized bovine bone mineral (DBBM). CAL, pocket probing depth (PPD), and gingival recession (GR) were recorded at baseline, 3, and 6 months postoperatively. Periapical radiographs were taken at baseline, immediately, and 6 months after surgery. Early wound healing index (EHI) and patients' responses were recorded at 2 weeks postoperatively.ResultsAt 6 months post‐surgery, the mean CAL gain was 3.1 ± 1.5 mm in the NCM group and 2.9 ± 1.5 mm in the RCCM group, while the mean PPD was 4.3 ± 1.1 mm in the NCM group and 4.2 ± 1.0 mm in the RCCM group. Both groups demonstrated a statistically significant improvement from the baseline (p < .01). RCCM was non‐inferior to NCM concerning the primary outcome (CAL gain at 6 months). The GR at 6 months postoperatively was 1.3 ± 1.2 and 1.2 ± 1.1 mm, which showed no difference compared with baseline. At 6 months follow‐up, the radiographic linear bone fill (RLBF) was 6.5 ± 2.8 and 5.5 ± 2.6 mm (p > .05), while the bone fill percentage (BF%) was 102.3 ± 53.5% and 92.3 ± 40.1% (p > .05), in the NCM and RCCM groups, respectively. There was no significant difference in EHI and postoperative responses between two groups.ConclusionRCCM + DBBM resulted in no‐inferior clinical and radiographic outcomes to NCM + DBBM for the treatment of isolated infrabony defect in 6 months.

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A photoresponsive recombinant human amelogenin‐loaded hyaluronic acid hydrogel promotes bone regeneration

Cited by 2 publications

References 40 publications

Hydrogels promote periodontal regeneration

Hydrogels promote periodontal regeneration

Native vs. ribosome‐crosslinked collagen membranes for periodontal regeneration: A randomized clinical trial

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