A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Zhou, Chuncai; Li, Peng; Xiang-yang, QI; Sharif, Abdul Rahim Mohamed; Poon, Yin Fun; Cao, Yilin; Chang, Matthew Wook; Leong, Susanna Su Jan; Chan‐Park, Mary B.

doi:10.1016/j.biomaterials.2010.12.040

Cited by 217 publications

(177 citation statements)

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“…It has also been shown that PLL grafted with certain other materials for medical implants can have antimicrobial effects. 74 Various coating strategies/techniques exist, but here the focus is on adsorption processes as in Papers 1 and 2. The general adsorption of a polyelectrolyte onto a solid surface of the opposite charge follows the characteristics as in Figure 14.…”

Section: Figure 13 Chemical Structure Of Poly-l-lysine (Pll)mentioning

confidence: 99%

Electrodes and Electrokinetic Systems for Biotechnological Applications

Nilsson¹

2015

Linköping Studies in Science and Technology. Dissertations

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Research in bioelectronics studies biological systems and materials in combination with electronic interfaces for the development of devices, e.g., for medical applications, drug and toxicity tests, and biotechnology in general. Neural implants and pacemakers are examples of products developed from this area of research. Conducting polymers such as poly(3,4-ethylenedioxythiophene) (PEDOT) bridge biology and electronics with a combination of biocompatibility, flexibility, and capability to themselves undergo redox reactions. Electrokinetics, a related branch of science, describes the motion of fluids and particles caused by the application of an electric field, and includes various separation techniques such as gel electrophoresis. Applying an electric field in a sufficiently small diameter silica capillary can cause the liquid in the capillary to move. This phenomenon, referred to as electroosmosis, plays an important role in miniaturized microfluidic systems and can be used to drive flow in a so-called electroosmotic pump.This thesis describes research at the interface between biology, chemistry and electronics. The first two papers probe the adsorption mechanism of poly-L-lysine, often used in biotechnological applications, onto hard materials such as metals (platinum) and metal oxides (indium tin oxide). By employing a gravimetric technique, quartz crystal microgravimetry with dissipation monitoring (QCM-D) combined with electrochemistry, we studied the process by which poly-L-lysine is deposited onto two different conducting substrates under anodic conditions. We found that indium tin oxide is more suitable than platinum for anodic electrodeposition of PLL, however, the exact film deposition mechanism is not fully understood. Paper 3 demonstrates the applicability of using conducting polymers, (e.g., PEDOT) instead of platinum as electrode material in gel electrophoresis. The last paper describes the fabrication and characterization of an electroosmotic pump consisting of a potassium silicate stationary phase in a fused silica capillary and the integration of the pump into a system for use, e.g., as a bioreactor. Populärvetenskaplig sammanfattningBiologi och elektronik har historiskt varit två separata forskningsområden som i nuläget till stor del även kombineras inom fältet bioelektronik. Ett viktigt exempel inom bioelektroniken är utvecklingen av pacemakern under 1950-talet. Andra exempel på applikationer är bl. a. biosensorer, neurologiska implantat och miniatyriserade analyssystem, s.k. Lab-On-a-Chip. Inom bioelektronik syftar man till att studera och påverka biologiska system och material med elektroteknik. År 2000 gavs Nobelpriset i kemi till Heeger, MacDiarmid och Shirakawa för deras utveckling av elektriskt ledande polymerer samt möjligheten att öka dess ledningsförmåga genom en process som kallas dopning. Konjugerade polymerer såsom poly(3,4-ethylenedioxythiophene) (PEDOT) är viktiga verktyg för att binda samman biologi med elektronik genom deras flexibilitet, biokompatibilitet samt förmågan...

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Section: Figure 13 Chemical Structure Of Poly-l-lysine (Pll)mentioning

confidence: 99%

Electrodes and Electrokinetic Systems for Biotechnological Applications

Nilsson¹

2015

Linköping Studies in Science and Technology. Dissertations

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“…Consistently, internalisation of CXCR4 by the interaction with its ligand, CXCL12, has been previously described in lymphoma cells that come into contact with stromal cells, [43] and also in multiple myeloma cells. [52] Moreover, the antitumour activity of the nanoparticle was partially reversed by the pre-treatment with a CXCR4 antagonist, AMD3100, which demonstrates that its effect is, at least in part, mediated by CXCR4.…”

Section: Evaluation Of Silica Mesoporous Nanoparticles In the Toledo-mentioning

confidence: 53%

“…However, some ligands also promote rapid clearance by phagocytes. [43,44] One of the plausible reductionist approaches is the use of peptides that specifically bind to the target cells while being stealthy to phagocytes so as to inhibit their clearance.…”

Section: Biocompatibility-cytotoxicitymentioning

confidence: 99%

“…[39] The result of this One of the most used procedures to obtain colloidal mesoporous silica is the Stöber method. [40][41][42][43] This method used several bases (KOH, NaOH, ammonia, triethanolamine) and a silica source (tetraetylortosilicate, TEOS) to prepare mesoporous silica nanoparticles with diameters in the 20-150 nm interval.…”

Section: Scheme 12mentioning

confidence: 99%

“…[43] CXCR4 overexpression has also been associated with poor prognosis in several B-cell malignancies. [44,45] Moreover, in diffuse large B-cell lymphoma, the most frequent B-NHL subtype, CXCR4…”

Section: Introductionmentioning

confidence: 99%

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Nanotechnology and supramolecular chemistry in controlled release and molecular recognition proceses for biomedical applications"

Paredes¹

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CERTIFY:That the work "Nanotechnology and supramolecular chemistry in controlled release and molecular recognition processes for biomedical applications" has been AgradecimientosComo en cualquier carrera de fondo, lo importante de llegar a meta es todo lo que aprendes en el camino. Llegados a este punto, donde me encuentro en la recta final para cruzar la línea de meta, es importante echar la vista atrás y agradecer a todas esas personas que dia a dia te ayudan a continuar caminando, a no detenerte y a afrontar los distintos obstáculos que te encuentras.En primer lugar, agradecer a mi director, el Profesor Ramón Matinez Mañez por darme la oportunidad de realizar la tesis doctoral en su grupo de investigación. Gracias por confiar en mi desde el primer momento, siempre recordaré la entrevista en la que me comentabas que realizaría ensayos en células porque la doctora que se ocupa de ellos se marchaba en breve y yo te contesté, con total sinceridad, que no tenía ningún conocimiento de cultivos celulares pero que aprendería sin problemas (en ese momento en mi cabeza pensaba : "y yo que estudié dibujo técnico en lugar de biología en Bachillerato…mare meua!"). Gracias por darme la oportunidad de crecer "químicamente", por la libertad e independencia que me has dado durante este periodo ya que gracias a ello he aprendido a superar los obstáculos y problemas que surgen, a "buscarme las castañas".Como no, agradecer a Félix Sancenón por ser mi segundo director, por ser el filtro de todos los papers, la persona que siempre está disponible para responder tus dudas experimentales, para corregirte lo que necesites y siempre con una eficiencia difícil de mejorar. Considero que todo el trabajo realizado ha sido posible gracias a tu ayuda y a tus consejos y positividad. Haces las cosas mucho más fáciles, al principio, durante y ahora en la recta final, ayudándome con todos los trámites de la tesis.También agradecer la ayuda prestada a Loles, Jose Vicente, Jose Ramón Murguía y Luis Villaescusa (y sus clases y conversaciones en la sala del Rayos X). AgradecimientosGracias a Quique y Eva, por todos los trámites que nos facilitais, por solucionar los lios de compras en los que nos metemos a veces y por vuestra eficiencia.Muchisimas gracias a Mar Orzaez y Enrique Pérez Payá, por todo lo que me habéis enseñado y por la paciencia que tuvisteis conmigo en los inicios de la tesis.Gracias por aceptarme en vuestro laboratorio y hacer que fuera una más en él.Gracias a Maria José Alcaraz y a su laboratorio, en especial a Carmen Terencio.Gracias por lo que me has enseñado, por como me has tratado, de tú a tú y por la confianza que has puesto en mi. Gracias a Reynaldo por las colaboraciones que hemos realizado y el trabajo en equipo que tan bien organiza.Inifinitas gracias a Eduardo Ruiz, por recibirme con los brazos abiertos en su laboratorio de Dublin. "Una actitud positiva causa una reacción en cadena de pensamientos, sucesos y resultados positivos". Esta frase te define a la perfección.Durante el tiempo que estuvimos trabajando juntos des...

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Antimicrobial Biopolymers

Sayed¹,

Jardine²

2015

Advanced Functional Materials

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A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Cited by 217 publications

References 38 publications

Electrodes and Electrokinetic Systems for Biotechnological Applications

Electrodes and Electrokinetic Systems for Biotechnological Applications

Nanotechnology and supramolecular chemistry in controlled release and molecular recognition proceses for biomedical applications"

Antimicrobial Biopolymers

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