A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers

Cognetti, John S.; Moen, Maya T; Bryan, Michael; Tice, Joshua D.; Brewer, Matthew G.; McGrath, James L.; Miller, Benjamin L.

doi:10.1039/d2lc00864e

Cited by 16 publications

(9 citation statements)

References 67 publications

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“…212 More recently, the group of Cognetti et al demonstrated the use of integrated microring resonators on so-called "disposable chips" embedding microfluidics for the detection of COVID-19 213 and real-time sensing of lung epithelial inflammatory markers (Figure 17). 214 In these original works, the researchers show the possibility to achieve organs-on-a-chip by measuring several targets secreted from cells maintained by a barrier. This innovative concept opens the way to new types of applications and real-time multiplexing.…”

Section: ■ Toward Practical Applicationsmentioning

confidence: 99%

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From Whispering Gallery Mode Resonators to Biochemical Sensors

et al. 2023

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Optical biosensors are frontrunners for the rapid and real-time detection of analytes, particularly for low concentrations. Among them, whispering gallery mode (WGM) resonators have recently attracted a growing focus due to their robust optomechanical features and high sensitivity, measuring down to single binding events in small volumes. In this review, we provide a broad overview of WGM sensors along with critical advice and additional “tips and tricks” to make them more accessible to both biochemical and optical communities. Their structures, fabrication methods, materials, and surface functionalization chemistries are discussed. We propose this reflection under a pedagogical approach to describe and explain these biochemical sensors with a particular focus on the most recent achievements in the field. In addition to highlighting the advantages of WGM sensors, we also discuss and suggest strategies to overcome their current limitations, leaving room for further development as practical tools in various applications. We aim to provide new insights and combine different knowledge and perspectives to advance the development of the next generation of WGM biosensors. With their unique advantages and compatibility with different sensing modalities, these biosensors have the potential to become major game changers for biomedical and environmental monitoring, among many other relevant target applications.

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Section: ■ Toward Practical Applicationsmentioning

confidence: 99%

Section: Toward Practical Applicationsmentioning

confidence: 99%

From Whispering Gallery Mode Resonators to Biochemical Sensors

et al. 2023

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“…In another study, Cognetti et al developed a photonic biosensor-based monitoring system for inflammatory cytokines in a lung-on-a-chip system [42]. The biosensor consisted of two sets of 14 silicon nitride photonic ring resonators, with each set featuring an edge-coupled 8-waveguide array.…”

Section: Optical Biosensingmentioning

confidence: 99%

In situ biosensing technologies for an organ-on-a-chip

Kim,

Jin

et al. 2023

Biofabrication

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The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying in vivo experiments. Organoids and organs-on-chips have been developed to model the in vitro, real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the in vitro, real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate the close representations of the in vivo environment. In this review, we discuss the biosensing technology that facilitates the in situ, real-time measurements of organ responses as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will be established by further advancing the development of chips, as well as their assessment techniques.

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“…Therefore, many researchers are interested in studying defective digestive, immune, and endocrine functions as well as diseases such as infection, inflammation, and cancer using animal models. These models have been enormously challenged by unethical and costly issues caused by using different kinds of animals [ 27 , 28 , 29 , 30 , 31 ]. Therefore, a lab-on-a-chip was proposed as a solution to replace animal models with many unsolvable problems.…”

Section: Introductionmentioning

confidence: 99%

Bio–Microfabrication of 2D and 3D Biomimetic Gut-on-a-Chip

Jang,

Jung,

2023

Micromachines

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Traditional goal of microfabrication was to limitedly construct nano- and micro-geometries on silicon or quartz wafers using various semiconductor manufacturing technologies, such as photolithography, soft lithography, etching, deposition, and so on. However, recent integration with biotechnologies has led to a wide expansion of microfabrication. In particular, many researchers studying pharmacology and pathology are very interested in producing in vitro models that mimic the actual intestine to study the effectiveness of new drug testing and interactions between organs. Various bio–microfabrication techniques have been developed while solving inherent problems when developing in vitro micromodels that mimic the real large intestine. This intensive review introduces various bio–microfabrication techniques that have been used, until recently, to realize two-dimensional and three-dimensional biomimetic experimental models. Regarding the topic of gut chips, two major review subtopics and two-dimensional and three-dimensional gut chips were employed, focusing on the membrane-based manufacturing process for two-dimensional gut chips and the scaffold-based manufacturing process for three-dimensional gut chips, respectively.

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A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers

Abstract: Tissue chip (TC) devices seek to mimic human physiology on a small scale. They are intended to improve upon animal models in terms of reproducibility and human relevance, at a...

Cited by 16 publications

References 67 publications

From Whispering Gallery Mode Resonators to Biochemical Sensors

From Whispering Gallery Mode Resonators to Biochemical Sensors

In situ biosensing technologies for an organ-on-a-chip

Bio–Microfabrication of 2D and 3D Biomimetic Gut-on-a-Chip

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