A photoCORM nanocarrier for CO release using NIR light

Pierri, Agustin E.; Huang, Po-Ju; Garcia, John V.; Stanfill, James G.; Chui, Megan; Wu, Guang; Zheng, Nanfeng; Ford, Peter C.

doi:10.1039/c4cc06766e

Cited by 119 publications

(119 citation statements)

References 42 publications

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“…However, there have been few reports on the effects of CO released into cells and tissues by light irradiation of the photoactive CORMs. [36][37][38] To adapt the reactivities of photoactive CORMs to cellular environments,i ti se ssential to design scaffolds with improved biocompatibility such as proteins because several proteins have great potential to deliver CORMs. [39][40][41][42][43] In this work, we developed ap hotoactive CO-releasing protein based on ferritin (Fr), an iron storage protein.…”

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confidence: 99%

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

et al. 2015

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Protein cages can serve as bioinorganic molecular templates for functionalizing metal compounds to regulate cellular signaling. We succeeded in developing a photoactive CO-releasing system by constructing a composite of ferritin (Fr) containing manganese-carbonyl complexes. When Arg52 adjacent to Cys48 of Fr is replaced with Cys, the Fr mutant stabilizes the retention of 48 Mn-carbonyl moieties, which can release the CO ligands under light irradiation, although wild-type Fr retains very few Mn moieties. The amount of released CO is regulated by the extent of irradiation. This could reveal an optimized dose for cooperatively activating the nuclear factor κB (NF-κB) in mammalian cells and the tumor necrosis factor α (TNF-α). These results suggest that construction of a CO-releasing protein cage will advance of research in CO biology.

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confidence: 99%

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

et al. 2015

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“…Ford and co-workers showedt hat the NIR irradiation of UCNPs loaded with either the Roussin black salt anion or the photoactivated CO-releasing moiety (photoCORM) trans-[Mn(2,2'-bipyridine)(PPh 3 ) 2 (CO) 2 ] results in the release of NO and CO, respectively. [13,14] Similarly, we have demonstrated that related upconversion nanosystems promoted the release of pyridine fromaR u-polypyridyl complex [16] and the generation of aP t II speciesf rom aP t IV prodrug candidate. [17] Alternatively,H ee tal.…”

Section: Introductionmentioning

confidence: 91%

Upconverting Nanoparticles Prompt Remote Near‐Infrared Photoactivation of Ru(II)–Arene Complexes

Ruggiero

Garino

Mareque‐Rivas

et al. 2016

Chemistry A European J

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The synthesis and full characterisation (including X-ray diffraction studies and DFT calculations) of two new piano-stool Ru(II) -arene complexes, namely [(η(6) -p-cym)Ru(bpy)(m-CCH-Py)][(PF)6]2 (1) and [(η(6) -p-cym)Ru(bpm)(m-CCH-Py)][(PF)6]2 (2; p-cym=p-cymene, bpy=2,2'-bipyridine, bpm=2,2'-bipyrimidine, and m-CCH-Py=3-ethynylpyridine), is described and discussed. The reaction of the m-CCH-Py ligand of 1 and 2 with diethyl-3-azidopropyl phosphonate by Cu-catalysed click chemistry affords [(η(6) -p-cym)Ru(bpy)(P-Trz-Py)][(PF)6]2 (3) and [(η(6) -p-cym)Ru(bpm)(P-Trz-Py)][(PF)6]2 (4; P-Trz-Py=[3-(1-pyridin-3-yl-[1,2,3]triazol-4-yl)-propyl]phosphonic acid diethyl ester). Upon light excitation at λ=395 nm, complexes 1-4 photodissociate the monodentate pyridyl ligand and form the aqua adduct ions [(η(6) -p-cym)Ru(bpy)(H2O)](2+) and [(η(6) -p-cym)Ru(bpm)(H2O)](2+). Thulium -doped upconverting nanoparticles (UCNPs) are functionalised with 4, thus exploiting their surface affinity for the phosphonate group in the complex. The so-obtained nanosystem UCNP@4 undergoes near-infrared (NIR) photoactivation at λ=980 nm, thus producing the corresponding reactive aqua species that binds the DNA-model base guanosine 5'-monophosphate.

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Section: Synthetic Polymer Materialsmentioning

confidence: 99%

“…58 Ford and co-workers utilized Tm and Yb-doped NaGdF 4 upconversion nanoparticle (UCNP) as a template for the construction of CORMs. 58 When the UCNP is irradiated with NIR light, the molecule emits visible range photons which have the potential to trigger CO release. To achieve NIR-induced CO release, the UCNP and a [Mn(bpy)(CO) 2 (PPh 3 ) 2 ] + complex were simultaneously encapsulated in an amphiphilic phospholipidfunctionalized PEG micelle (Fig.…”

Section: Synthetic Polymer Materialsmentioning

confidence: 99%

Design of biomaterials for intracellular delivery of carbon monoxide

2015

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Carbon monoxide (CO) is recognized as one of the most important gas signaling molecules involved in governing various therapeutic responses. Intracellular generation of CO is spatiotemporally controlled by catalytic reactions of heme oxygenases (HOs). Thus, the ability to control intracellular CO delivery with modulation of the CO-release rate in specific amounts and locations is expected to improve our fundamental understanding of the functions of CO and the development of clinical applications. For this purpose, CO-releasing molecules (CORMs) have been developed and investigated in vitro and in vivo. Most CORMs are based on transition metal carbonyl complexes. Recently, various biomaterials consisting of metal carbonyls with biomacromolecular scaffolds have been reported to improve the properties of bare metal carbonyls. In this mini-review, current progress in CO delivery, recent strategies for the development of CORMs, and future directions in this field are discussed.

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A photoCORM nanocarrier for CO release using NIR light

Abstract: Amphiphilic polymer conjugates with upconverting nanoparticles serve as water-soluble nanocarriers for NIR-photochemical delivery of CO from hydrophobic photoCORMS.

Cited by 119 publications

References 42 publications

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

Upconverting Nanoparticles Prompt Remote Near‐Infrared Photoactivation of Ru(II)–Arene Complexes

Design of biomaterials for intracellular delivery of carbon monoxide

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