A Photochemical Protocol for the Synthesis of Weinreb and Morpholine Amides from Carboxylic Acids Cover Feature: (Eur. J. Org. Chem. 24/2023)

Abstract

The Cover Feature illustrates the photochemical conversion of carboxylic acids to Weinreb and morpholine amides. Sunlight or LED 370 nm irradiation mediates the direct coupling of carboxylic acids to N,O‐dimethylhydroxylamine or morpholine in the presence of 4‐dimethylaminopyridine and bromotrichloromethane, providing the corresponding amides in satisfactory to high yields. More information can be found in the Research Article by C. G. Kokotos, G. Kokotos et al.