A photoactivated nanofiber graft material for augmented Achilles tendon repair

Tien, Ni; Senthilkumar, P.; Dubbin, Karen; Aznar-Cervantes, Salvador D.; Datta, Néha; Randolph, Mark A.; Cenis, J. L.; Rutledge, Gregory C.; Kochevar, Irene E.; Redmond, Robert W.

doi:10.1002/lsm.22066

Cited by 43 publications

(39 citation statements)

References 29 publications

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“…Importantly, our mechanical measures are similar to those reported in the literature. We found a mean elastic modulus of 250 MPa and mean ultimate stress of 34 MPa, which are within the 20-350 MPa (Leek et al 2012, Kahn et al 2013; Nagasawa et al 2008; Ni et al 2012; Reddy et al 1999; Reddy 2004; Revel et al 2003) and 8-40 MPa (Leek et al 2002; Nagasawa et al 2008; Ni et al 2012; Reddy et al 1999; Reddy 2004) ranges reported for the elastic modulus and ultimate stress, respectively, of healthy rabbit Achilles tendons.…”

Section: Discussionsupporting

confidence: 81%

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength

Martin

Biedrzycki

Lee

et al. 2015

Ultrasound in Medicine & Biology

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The purpose of this study was to assess the potential for ultrasound shear wave elastography (SWE) to assess tissue elasticity and ultimate stress in both intact and healing tendons. The lateral gastrocnemius (Achilles) tendons of 41 New Zealand white rabbits were surgically severed and repaired with growth factor coated sutures. SWE imaging was used to measure shear wave speed (SWS) in both the medial and lateral tendons pre-surgery, and at 2 and 4 weeks post-surgery. Rabbits were euthanized at 4 weeks, and both medial and lateral tendons underwent mechanical testing to failure. SWS significantly (p<0.001) decreased an average of 17% between the intact and post-surgical state across all tendons. SWS was significantly (p<0.001) correlated with both the tendon elastic modulus (r = 0.52) and ultimate stress (r = 0.58). Thus, ultrasound SWE is a potentially promising noninvasive technology for quantitatively assessing the mechanical integrity of pre-operative and post-operative tendons.

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Section: Discussionsupporting

confidence: 81%

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength

Martin

Biedrzycki

Lee

et al. 2015

Ultrasound in Medicine & Biology

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“…First of all, the postoperative treatment has to be optimized with respect to its impact on the adhesion extent as it is well known that for example in Achilles tendon regeneration the ankle angle plays a crucial role [5]. Secondly, physical antiadhesion barriers consisting of biomaterials such as fibronectin [6], collagen [3], or silk [7] have been reported to show positive effects with respect to reducing adhesion formation. Finally, antiadhesive agents were beneficially administered such as 5-fluorouracil [8], hyaluronic acid, and ADCON-T/N, being a gelatine-polyglycan ester compound [9] or anti-inflammatory drugs like ibuprofen [10].…”

Section: Introductionmentioning

confidence: 99%

Prevention of Peritendinous Adhesions Using an Electrospun DegraPol Polymer Tube: A Histological, Ultrasonographic, and Biomechanical Study in Rabbits

Bürgisser

Calcagni

Müller

et al. 2014

BioMed Research International

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Purpose. One of the great challenges in surgical tendon rupture repair is to minimize peritendinous adhesions. In order to reduce adhesion formation, a physical barrier was applied to a sutured rabbit Achilles tendon, with two different immobilization protocols used postoperatively. Methods. Thirty New Zealand white rabbits received a laceration on the Achilles tendon, sutured with a 4-strand Becker suture, and half of the rabbits got a DegraPol tube at the repair site. While fifteen rabbits had their treated hind leg in a 180° stretched position during 6 weeks (adhesion provoking immobilization), the other fifteen rabbits were recasted with a 150° position after 3 weeks (adhesion inhibiting immobilization). Adhesion extent was analysed macroscopically, via ultrasound and histology. Inflammation was determined histologically. Biomechanical properties were analysed. Results. Application of a DegraPol tube reduced adhesion formation by approximately 20%—independently of the immobilization protocol. Biomechanical properties of extracted specimen were not affected by the tube application. There was no serious inflammatory reaction towards the implant material. Conclusions. Implantation of a DegraPol tube tightly set around a sutured tendon acts as a beneficial physical barrier and prevents adhesion formation significantly—without affecting the tendon healing process.

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“…Tissue engineering approaches using the rabbit model have been commonly used to address sequelae of Achilles pathology such as adhesions 88 and tendon defects. 89 For example, a recently developed electrospun silk wrap has been shown to be effective in providing significant reduction in adhesion formation in rabbit Achilles tendons, while also improving the biomechanical properties of the repaired tendon.…”

Section: Achillesmentioning

confidence: 99%

“…89 For example, a recently developed electrospun silk wrap has been shown to be effective in providing significant reduction in adhesion formation in rabbit Achilles tendons, while also improving the biomechanical properties of the repaired tendon. 88 Conversely, a new equine collagen membrane has shown histological signs of integrating into a rabbit Achilles tendon defect; however, the graft’s effects on resultant material properties or healing remains unknown. 89 As Achilles tendon ruptures appear to be on the rise, 90,91 this work could prove instrumental in improving both the strength and quality of operative tendon repair.…”

Section: Achillesmentioning

confidence: 99%

The role of animal models in tendon research

Hast

Zuskov

Soslowsky

2014

Bone & Joint Research

110

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Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing.Cite this article: Bone Joint Res 2014;3:193–202.

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A photoactivated nanofiber graft material for augmented Achilles tendon repair

Abstract: Photochemical sealing of a ES mat around the tendon repair site provides considerable benefit in Achilles tendon repair. Lasers Surg. Med. 44: 645-652, 2012. © 2012 Wiley Periodicals, Inc.

Cited by 43 publications

References 29 publications

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength

Prevention of Peritendinous Adhesions Using an Electrospun DegraPol Polymer Tube: A Histological, Ultrasonographic, and Biomechanical Study in Rabbits

The role of animal models in tendon research

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