A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing

Hu, Honghua; Zhai, Xinrang; Li, Wenyue; Ji, Shunxian; Dong, Wei; Chen, Wei-Yu; Wei, Wei; Lu, Zhihui

doi:10.1016/j.isci.2022.104619

Cited by 15 publications

(14 citation statements)

References 51 publications

(56 reference statements)

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“…A similar test was also performed for fresh pig skin with the standard ASTM F2255‐05 method. [ 98 ] First, the substrate was cleaned, the fat layer was removed, and the animal skin was cut into 15 × 20 mm rectangles before being moistened with PBS (pH = 7.4). 0.1 g of hydrogel was then coated on a 2.25 cm 2 area of one piece of pig skin followed by the application of a second piece of pig skin on top.…”

Section: Methodsmentioning

confidence: 99%

An Electroconductive and Antibacterial Adhesive Nanocomposite Hydrogel for High‐Performance Skin Wound Healing

Zheng,

Yang,

Wei

et al. 2023

Adv Healthcare Materials

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Multifunctional hydrogel adhesives inhibiting infections and enabling the electrical stimulation (ES) of tissue reparation are highly desirable for the healing of surgical wounds and other skin injuries. Herein, a therapeutic nanocomposite hydrogel is designed by integrating β‐cyclodextrin‐embedded Ag nanoparticles (CDAgNPs) in a polyvinyl alcohol (PVA) matrix enhanced with free β‐cyclodextrin (CD) and an atypical macromolecule made of β‐glucan grafted with hyaluronic acid (HAG). The main objective is to develop a biocompatible dressing combining the electroconductivity and antibacterial activity of CDAgNPs with the cohesiveness and porosity of PVA and the anti‐inflammatory, moisturizing, and cell proliferation‐promoting properties of HAG. The last component, CD, is added to strengthen the network structure of the hydrogel. PVA/CD/HAG/CDAgNP exhibited excellent adhesion strength, biocompatibility, electroconductivity, and antimicrobial activity against a wide range of bacteria. In addition, the nanocomposite hydrogel has a swelling ratio and water retention capacity suitable to serve as a wound dressing. PVA/CD/HAG/CDAgNP promoted the proliferation of fibroblast in vitro, accelerated the healing of skin wounds in an animal model, and is hemostatic. Upon ES, the PVA/CD/HAG/CDAgNP nanocomposite hydrogel became more efficient both in vitro and in vivo further speeding up the skin healing process thus demonstrating its potential as a next‐generation electroconductive wound dressing.

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Section: Methodsmentioning

confidence: 99%

An Electroconductive and Antibacterial Adhesive Nanocomposite Hydrogel for High‐Performance Skin Wound Healing

Zheng,

Yang,

Wei

et al. 2023

Adv Healthcare Materials

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“…A variety of biomaterials, including membranes, electrospun nanofibers, colloidal nanoparticles, and hydrogels, have been used to facilitate the controlled release of bioactive molecules for skin regeneration (Liang et al, 2019;Bai et al, 2022;Hu et al, 2022). Among them, hydrogels have recently attracted attention for applications as delivery systems and scaffold dressings with multifunctional properties such as antibacterial activity, hemostatic ability, tissue adhesion, anti-ultraviolet activity, injectability, and self-healing (Lokhande et al, 2018;Safari et al, 2022).…”

Section: Co-administration With Hydrogelsmentioning

confidence: 99%

“…Other strategies such as engineering of hybrid exosomes may also be used in exosome modification (Chen et al, 2020). Furthermore, encapsulating exosomes into hydrogel scaffolding can be used to form a sustained release system or wound dressing (Liang et al, 2019;Bai et al, 2022;Hu et al, 2022). Preclinical studies and clinical trials of chronic wound models have shown promising results, demonstrating that modified MSC-exosomes could promote angiogenesis, fibrogenesis, re-epithelization, and granulation tissue formation, as well as attenuating inflammation (Shi et al, 2020b;Li et al, 2020;Wu et al, 2021a;Xiong et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Bioengineered MSC-derived exosomes in skin wound repair and regeneration

Zhao

Wang

et al. 2023

Front. Cell Dev. Biol.

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Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed.

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“…The well-known therapeutic strategies for diabetic wound healing involve blood glucose regulation, wound debridement, revascularization, wound decompression, and wound dressing . Among these therapeutic regimens, wound dressing is applied widely in the clinic owing to the isolation from an external environment and the delivery of medicine to wound sites directly . Multiple kinds of wound dressings have been developed for accelerating diabetic wound healing, like biocompatible membranes, electrospun fibers, and functional hydrogels .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an Adhesive Small Intestinal Submucosa Acellular Matrix Hydrogel for Accelerating Diabetic Wound Healing

Chen,

Hu,

et al. 2023

ACS Omega

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The treatment of diabetic skin defects comes with enormous challenges in the clinic due to the disordered metabolic microenvironment. In this study, we therefore designed a novel composite hydrogel (SISAM@HN) with bioactive factors and tissue adhesive properties for accelerating chronic diabetic wound healing. Hyaluronic acid (HA) modified by N -(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitrosophenoxy) butanamide (NB) held the phototriggering tissue adhesive capacity. Decellularized small intestinal submucosa (SIS) was degreased and digested to form the acellular matrix, which facilitated bioactive factor release. The results of the burst pressure test demonstrated that the in situ formed hydrogel possessed a tissue adhesive property. In vitro experiments, based on bone marrow stromal cells, revealed that the SIS acellular matrix-containing hydrogel contributed to promoting cell proliferation. In vivo , a diabetic mouse model was created and used to evaluate the tissue regeneration function of the obtained hydrogel, and our results showed that the synthesized hydrogel could assist collagen deposition, attenuate inflammation, and foster vascular growth during the wound healing process. Overall, the SIS acellular matrix-containing HA hydrogel was able to adhere to the wound sites, promote cell proliferation, and facilitate angiogenesis, which would be a promising biomaterial for wound dressing in clinical therapy of diabetic skin defects.

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A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing

Cited by 15 publications

References 51 publications

An Electroconductive and Antibacterial Adhesive Nanocomposite Hydrogel for High‐Performance Skin Wound Healing

An Electroconductive and Antibacterial Adhesive Nanocomposite Hydrogel for High‐Performance Skin Wound Healing

Bioengineered MSC-derived exosomes in skin wound repair and regeneration

Fabrication of an Adhesive Small Intestinal Submucosa Acellular Matrix Hydrogel for Accelerating Diabetic Wound Healing

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