A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator ofAcinetobacterresistance and virulence
Nicole Raustad,
Yunfei Dai,
Akira Iinishi
et al.
Abstract:The nosocomial pathogenAcinetobacter baumanniiis a major threat to human health. The sensor kinase-response regulator system, BfmS-BfmR, is essential to multidrug resistance and virulence in the bacterium and represents a potential antimicrobial target. Important questions remain about how the system controls resistance and pathogenesis. Although BfmR knockout alters expression of >1000 genes, its direct regulon is undefined. Moreover, how phosphorylation controls the regulator is unclear. Here, we address … Show more
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