A phospholipase A2 inhibitor fromArisaema amurense Max. var.serratum Nakai

Chung, Won-Yoon; Goo, Yang Mo; Na, Do Sun; Kim, Kyeong Ja

doi:10.1007/bf02976416

Cited by 12 publications

(6 citation statements)

References 5 publications

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“…Comparative analysis of NMR data with the reported literature identified compounds 4-11 as (3S,4S)-sclerotinin A (4) [8], (R)-6-hydroxymellein (5) [9], chrodrimanin E (6) [3], (9Z,12Z)-octadeca-9,12-dienoic acid (7) [10], methyl (9Z,12Z)-octadeca-9,12-dienoate (8) [11], 2,3-dihydroxypropyl (9Z,12Z)-octadecadienoate (9) [12], phenyl acetic acid (10) [13], and (S)-3-amino-2-phenylpropionic acid (11) [14], respectively. Compound 2 was characterized by a proton adduct ion, m/z 429.2280 (Figure S9), from which the molecular formula C25H32O6 was inferred, indicating a total of ten degrees of unsaturation.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Pentaketide-Sesquiterpenes from the Marine-Derived Fungus Talaromyces variabilis M22734

Tang,

Xia,

Chen

et al. 2024

Marine Drugs

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Talaromyces, a filamentous fungus widely distributed across terrestrial and marine environments, can produce a diverse array of natural products, including alkaloids, polyketones, and polyketide-terpenoids. Among these, chrodrimanins represented a typical class of natural products. In this study, we isolated three previously undescribed pentaketide-sesquiterpenes, 8,9-epi-chrodrimanins (1–3), along with eight known compounds (4–11). The structures of compounds 1–3 were elucidated using nuclear magnetic resonance (NMR) and mass spectrometry (MS), while their absolute configurations were determined through X-ray crystallography and electronic circular dichroism (ECD) computations. The biosynthetic pathways of compounds 1–3 initiate with 6-hydroxymellein and involve multiple stages of isoprenylation, cyclization, oxidation, and acetylation. We selected four strains of gastrointestinal cancer cells for activity evaluation. We found that compound 3 selectively inhibited MKN-45, whereas compounds 1 and 2 exhibited no significant inhibitory activity against the four cell lines. These findings suggested that 8,9-epi-chrodrimanins could serve as scaffold compounds for further structural modifications, potentially leading to the development of targeted therapies for gastric cancer.

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Section: Resultsmentioning

confidence: 99%

Cytotoxic Pentaketide-Sesquiterpenes from the Marine-Derived Fungus Talaromyces variabilis M22734

Tang,

Xia,

Chen

et al. 2024

Marine Drugs

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“…The tested phytoconstituents chemical structures were collected from the literature (Scifinder, Pubmed, Google Scholar). [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]…”

Section: Methodsmentioning

confidence: 99%

IN- SILICO DISCOVERY OF NATURAL LEAD HITS FROM THE GENUS OF Arisaema AGAINST HUMAN RHINO VIRUS

Kant

Lal

Ghosh

2016

Proceedings of the 20th International Electronic Conference on Synthetic Organic Chemistry

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Human rhino viruses (HRVs) serve as an imperative precursor for frequent cases of the common cold among children worldwide. An in-silico molecular docking attempt was made of some chief phytochemical entities (Arisaema plant species) as inhibitors of HRVs with selective therapeutic target action and minimal side effects. Around 60 phytoconstituents of different Arisaema species were docked against HRV receptor (PDB: 2XYA). Binding conformers of test ligands were compared with internal ligand. Finally, Syringaresinol 4'-O-β-D-glucopyranoside (glide score: -10.86), Rutin (glide score: -9.04) & Apigenin-6,8-di-C-β-D-glucopyranoside (glide score: -7.88) have resulted in most promising hits which can be further act as an effective template to experimentally validate or further designed their choosy and budding analogue agents against HRVSs.

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“…Among these, six compounds -p-hydroxybenzaldehyde (1), p-coumaric acid (6), naringenin (10), 3-O-p-coumaroyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-O-βglucopyranosylpropanol (11), tricin (12), and tricin 7-O-b-D-glucopyranoside ( 13) -have been previously reported. [22][23][24][25][26][27][28] The remaining seven -salicylic acid (2), syringaldehyde (3), methyl cisp-hydroxycinnamate (4), methyl trans-p-hydroxycinnamate (5), 2,3-dihydrozypropyl 9Z,12Z-octadecadienoate ( 7), (+)-(6S,7aS)-epilolide ( 8), (-)-(6 R,7aS)-loliolide ( 9) -were first identified from the Sasa species (Figure 1).…”

Section: Phenolic Contents and Phytochemicalsmentioning

confidence: 99%

“…These seven compounds were identified from 1 H and 13 C NMR spectra analyses and confirmed to be consistent with the data reported in the literature. [22][23][24][25][26][27][28] The 1 H-NMR spectrum of compound 2 displayed resonance signals owing to aromatic protons at δ 7.67 (dd, J = 15.8, 2.3 Hz), 7.13 (dd, J = 9.0, 2.3 Hz), and 6.60 (2 H, dd, J = 15.8, 3.2 Hz). In contrast, in the 13 C-NMR spectrum, two displayed a prominent resonance signal at δ C 171.7 (C-7) for carbonyl carbon, a chemical shift of oxygen-bonded (C-3a) and two oxygenated carbons signal at δ C 65.2 (C-6) and 88.5 (C-7a).…”

Section: Phenolic Contents and Phytochemicalsmentioning

confidence: 99%

Elucidation of phytochemicals and antioxidants properties ofSasa quelpaertensis

Jang

Kim

et al. 2021

International Journal of Food Properties

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Sasa quelpaertensis Nakai extract (SQE) has long been used as a traditional medicine and health drink. The present study aims to examine the properties and antioxidant activity of the phytochemicals isolated from S. quelpaertensis. Therefore, the SQE was fractionated with n-hexane, chloroform (CHCl 3 ), ethyl acetate (EtOAc), and n-butanol (BuOH). Phytochemicals present in the solvent fraction were also isolated using a high-performance liquid chromatography (HPLC) system. In addition, their DPPH radical scavenging ability and NO production inhibitory effect were compared. The results showed that phytochemicals p-hydroxybenzaldehyde (1), salicylic acid (2), syringaldehyde (3), methyl cis-p-hydroxycinnamate (4), methyl trans-p-hydroxycinnamate (5), p-coumaric acid (6), 2,3-dihydrozypropyl 9Z,12Z-octadecadienoate ( 7), (+)-(6S,7aS)-epilolide ( 8), (-)-(6 R,7aS)-loliolide (9), naringenin (10), 3-O-p-coumaroyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-O-βglucopyranosylpropanol (11), tricin (12), and tricin 7-O-b-D-glucopyranoside (13) were isolated from CHCl 3 , EtOAc, and BuOH fractions and then identified using nuclear magnetic resonance (NMR) spectrometry. This is an initial study on compounds 2, 3, 4, 5, 7, 8, and 9 obtained from S. quelpaertensis. Compounds 11 (IC 50 120.3 μM) and 7 (IC 50 43.62 μM) showed significant DPPH radical scavenging activity and anti-inflammatory activity, respectively. We believe these results may provide the basic data for developing effective antioxidants using the SQE.

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A phospholipase A2 inhibitor fromArisaema amurense Max. var.serratum Nakai

Cited by 12 publications

References 5 publications

Cytotoxic Pentaketide-Sesquiterpenes from the Marine-Derived Fungus Talaromyces variabilis M22734

Cytotoxic Pentaketide-Sesquiterpenes from the Marine-Derived Fungus Talaromyces variabilis M22734

<strong><em>IN- SILICO</em></strong><strong> DISCOVERY OF NATURAL LEAD HITS FROM THE GENUS OF <em>Arisaema</em> AGAINST HUMAN RHINO VIRUS</strong>

Elucidation of phytochemicals and antioxidants properties ofSasa quelpaertensis

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