A Phenotypic Approach for Personalised Management of Obstructive Sleep Apnoea

Sutherland, Kate; Yee, Brendon J.; Kairaitis, Kristina; Wheatley, John R.; Chazal, Philip de; Cistulli, Peter A.

doi:10.1007/s40136-021-00346-6

Cited by 2 publications

(2 citation statements)

References 160 publications

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“…Tailoring OSA therapy based on the causes of sleep apnea in each individual has been proposed as a promising approach to precision medicine in OSA [ 21 ]. The overview of potential approaches to precision medicine in OSA, including factors beyond OSA’s physiological traits, is highlighted in other reports [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review

Chu,

Zinchuk

2024

JCM

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People with obstructive sleep apnea (OSA) are a heterogeneous group. While many succeed in the treatment of their OSA, many others struggle with therapy. Herein, we discuss how anatomical and physiological factors that cause sleep apnea (OSA traits) impact treatment response and may offer an avenue for more precise care. These OSA traits, including anatomical (upper-airway collapsibility) and physiological (loop gain, airway muscle responsiveness, and arousal threshold) factors, may help determine who can succeed with continuous positive airway pressure, oral appliances, hypoglossal nerve stimulation, or pharmacotherapy. In the future, identifying OSA traits before initiating treatment may help guide the selection of the most effective and tolerable therapy modalities for each individual.

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Section: Introductionmentioning

confidence: 99%

The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review

Chu,

Zinchuk

2024

JCM

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“…2 In recent years, there has been increasing recognition of OSA as a heterogenous disorder. 3,4 Specific phenotypes have been identified, [4][5][6] some of which have links to CVD. For example, an excessively sleepy symptom subtype has been linked to the development of CVD.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Symptom and Polysomnographic Profiles Associated with Cardiovascular Risk in a Sleep Clinic Population with Obstructive Sleep Apnoea

Kemp,

Sutherland,

Bin

et al. 2024

NSS

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Recent data have identified specific symptom and polysomnographic profiles associated with cardiovascular disease (CVD) in patients with obstructive sleep apnoea (OSA). Our aim was to determine whether these profiles were present at diagnosis of OSA in patients with established CVD and in those with high cardiovascular risk. Participants in the Sydney Sleep Biobank (SSB) database, aged 30-74 years, self-reported presence of CVD (coronary artery disease, cerebrovascular disease, or heart failure). In those without established CVD, the Framingham Risk Score (FRS) estimated 10-year absolute CVD risk, categorised as "low" (<6%), "intermediate" (6-20%), or "high" (>20%). Groups were compared on symptom and polysomnographic variables. Results: 629 patients (68% male; mean age 54.3 years, SD 11.6; mean BMI 32.3 kg/m 2 , SD 8.2) were included. CVD was reported in 12.2%. A further 14.3% had a low risk FRS, 38.8% had an intermediate risk FRS, and 34.7% had a high risk FRS. Groups differed with respect to age, sex and BMI. OSA severity increased with established CVD and increasing FRS. The symptom of waking too early was more prevalent in the higher FRS groups (p=0.004). CVD and FRS groups differed on multiple polysomnographic variables; however, none of these differences remained significant after adjusting for age, sex, and BMI. Conclusion: Higher CVD risk was associated with waking too early in patients with OSA. Polysomnographic variations between groups were explained by demographic differences. Further work is required to explore the influence of OSA phenotypic characteristics on susceptibility to CVD.

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A Phenotypic Approach for Personalised Management of Obstructive Sleep Apnoea

Cited by 2 publications

References 160 publications

The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review

The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review

Characterisation of Symptom and Polysomnographic Profiles Associated with Cardiovascular Risk in a Sleep Clinic Population with Obstructive Sleep Apnoea

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