A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: Isolation and identification from methanol extract of Euonymus alatus

Jin, Un‐Ho; Lee, Ji-Young; Kang, Suk‐Ku; Kim, June-Ki; Park, Won‐Hwan; Kim, Jong-Guk; Moon, Sung‐Kwon; Kim, Cheorl-Ho

doi:10.1016/j.lfs.2005.02.028

Cited by 196 publications

(114 citation statements)

References 33 publications

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“…Chlorogenic acid (CA) has antifungal [16], neuro-protective [17], cell immune responses [18] and hepatic glucose output effects [19]. Also, it is known to inhibit tumor cell invasion and metastasis [20]. Caffeic acid has antiulcer [21], anti-inflammatory [22] antioxidant [23] and anti-HIV [24] activities.…”

Section: Introductionmentioning

confidence: 99%

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Korkor¹,

Mohamed²,

Kafie³

et al. 2017

IOSRJPBS

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Section: Introductionmentioning

confidence: 99%

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Korkor¹,

Mohamed²,

Kafie³

et al. 2017

IOSRJPBS

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“…To the best of our knowledge this is the first study reporting the anti-invasive activity of extracts of Taraxacum species and especially of TO. The exact reason for the reduction in invasion can not be explained at present, as many of the known components in the roots and leaves can contribute to the observed effect (27)(28)(29) and this also depends on the composition of the extracts of the studied species.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Sigstedt

Hooten²,

Callewaert³

et al. 2008

Int J Oncol

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Abstract. Ethnotraditional use of plant-derived natural products plays a significant role in the discovery and development of potential medicinal agents. Plants of the genus Taraxacum, commonly known as dandelions, have a history of use in Chinese, Arabian and Native American traditional medicine, to treat a variety of diseases including cancer. To date, however, very few studies have been reported on the anti-carcinogenic activity of Taraxacum officinale (TO). In the present study, three aqueous extracts were prepared from the mature leaves, flowers and roots, and investigated on tumor progression related processes such as proliferation and invasion. Our results show that the crude extract of dandelion leaf (DLE) decreased the growth of MCF-7/AZ breast cancer cells in an ERK-dependent manner, whereas the aqueous extracts of dandelion flower (DFE) and root (DRE) had no effect on the growth of either cell line. Furthermore, DRE was found to block invasion of MCF-7/ AZ breast cancer cells while DLE blocked the invasion of LNCaP prostate cancer cells, into collagen type I. Inhibition of invasion was further evidenced by decreased phosphorylation levels of FAK and src as well as reduced activities of matrix metalloproteinases, MMP-2 and MMP-9. This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents. IntroductionPlants of the genus Taraxacum, also known as dandelions, are members of the Asteraceae family. These perennial plants are widespread throughout the warmer temperate zones of the Northern Hemisphere and have been used for centuries as a remedy for various ailments by several societies. Dandelions play a pivotal role in traditional Chinese medicine (TCM) and are frequently used for treatment of breast, uterine and lung tumors as well as hepatitis and digestive diseases (1,2), while Native Americans use dandelion roots and herbs to treat kidney disease, dyspepsia and heartburn. In traditional Arabian medicine, dandelions have been applied to remedy liver and spleen disorders (3), whereas European herbalists authorize the use of dandelions for fever, boils, eye problems, diabetes and diarrhea (4).The variety of health benefits associated with the use of dandelions has been attributed to specific Taraxacum species as extracts of the whole plants or specific plant parts. Anticarcinogenic activities have been reported for the aqueous root extract of Taraxacum japonicum on mouse skin tumors (5). Further study revealed that taraxasterol and taraxerol, triterpenoids isolated from T. japonicum, were responsible for the observed effect on mouse skin tumors and that taraxasterol inhibited spontaneous mammary carcinogenesis, after oral administration (6). Taraxinic acid, isolated from Taraxacum coreanum showed potent antiproliferative activity against HL-60 cells (7) and the ethanolic extracts of the Chinese dandelion root (Taraxacum mongolicum) inhibited the growth of B16 2F2 mouse melanoma cells (8). Antitumor...

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“…The active n-BuOH fraction was subfractionated using Diaion HP-20 resin with 20%, 40%, 60%, 80%, and 100% methanol, and five fractions were obtained: fraction 1 (6.6 g), fraction 2 (2.1 g), fraction 3 (3.7 g), fraction 4 (3.8 g), and fraction 5 (1.5 g). Finally, protocatechuic acid (peak 1, Gerothanassis et al 1998), chlorogenic acid (peak 2, Jin et al 2005), 3,5-di-O-caffeoylquinic acid (peak 4, Choi et al 2004), 1,3,5-tri-O-caffeoylquinic acid (peak 6, Agata et al 1993), and kaemferol-3-O-rutinoside (peak 8, Choi et al 2004) were isolated and identified as active principle compounds from fractions 3 and 5 by Sephadex LH-20 with 50% MeOH guided by Oil Red O staining in 3T3-L1 cells (Jang et al 2016) (Figure 1). And other four unknown compounds (peak 3, 5, 7, and 9) were isolated from fractions 2 and 4.…”

Section: Identification Of Chemical Compounds In Sv Extractmentioning

confidence: 99%

Anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat

Kim

Lee

Jang

et al. 2016

Animal Cells and Systems

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In our previous report, Solidago virgaurea var. gigantea (SV) extract was shown to exhibit antiadipogenesis activity in 3T3-L1 adipocyte cells. In this study, anti-obesity activity of SV extract was investigated in in vivo animal model. Sprague-Dawley (SD) rats were administered with highfat diet, and the effect of SV extract was tested. SD rats were treated orally with SV extract for eight weeks, and their body weight was measured every week. The oral treatment of SV extract decreased body weight, fat tissue weight, blood low-density lipoprotein-cholesterol level, and blood triglycerides level. The p-AMP-activated protein kinase (AMPK) (AMP kinase) protein level in the fat tissue of the SV extract-treated SD rats increased. The protein levels of AMPKdownstream proteins, c-AMP response element binding protein and acetyl-CoA carboxylase, fatty acid synthase, and FABP4 decreased, indicating that SV extract-activated AMPK induced inhibition of adipogenesis and lipid biosynthesis in fat tissue.1 H-NMR measurements of the lipid soluble liver extract showed a decrease in the lipid metabolites, indicating that SV extractactivated fatty acid oxidation in the liver. Overall, our results suggest that orally treated SV extract has excellent anti-obesity effect against HFD-induced obesity of SD rat. ARTICLE HISTORY

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A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: Isolation and identification from methanol extract of Euonymus alatus

Cited by 196 publications

References 33 publications

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat

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