A phenazine-imidazole based ratiometric fluorescent probe for Cd²⁺ ions and its application in in vivo imaging

Abstract

A new phenazine-imidazole based Schiff base (PIS) fluorescent probe have been developed for the ratiometric detection of Cd2+ ion in aqueous media at physiological pH. PIS upon binding with Cd2+...

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

“…In Figure 7, PIS was developed as a novel ratiometric phenazine-imidazole-Schiff base fluorescent probe [76].…”

A biphenyl thiosemicarbazide based fluorogenic chemosensor for selective recognition of Cd2+: application in cell bioimaging

“…49 A phenazine-imidazole based ratiometric fluorescent probe was designed by Wang et al to recognise Cd 2+ ions only in 2022, which showed a limit of detection value of 2.10 × 10 −8 (M). 50 Although Schiff bases containing N, O, S donors binding with Cd 2+ with 2 : 1 stoichiometry are less known, Rajesh et al in 2021 published a work on a quinoline based Schiff base for detecting cadmium in semi aqueous medium with 2 : 1 stoichiometry and a LOD value of 14.8 nM. 51 Now in this present work, we have successfully designed and fabricated a simple, cost-effective biphenyl thiosemicarbazide based fluorescent “turn-on” reversible chemosensor which detects Cd 2+ with a detection limit of (1.59 ± 0.054) × 10 −8 (M), which is a pretty good value compared to many previous reports.…”

Facile synthesis of neodymium vanadate nanoribbons and its application to highly efficient determination of cadmium ions

“…Among these heavy metal ions, cadmium ions are highly toxic to human beings and lead to serious damage to the nervous system, kidney and liver, causing metabolic disorders and other related diseases 4‐6 . Cd 2+ is a priority pollutant and tolerable Cd 2+ concentrations in water are limited as 27 nmol L −1 due to the strong toxic role of cadmium ions 7,8 . However, cadmium ions may be discarded to environments with living organisms from fossil fuel combustion, phosphate fertilizer and battery industries 9‐11 .…”

“…[4][5][6] Cd 2+ is a priority pollutant and tolerable Cd 2+ concentrations in water are limited as 27 nmol L −1 due to the strong toxic role of cadmium ions. 7,8 However, cadmium ions may be discarded to environments with living organisms from fossil fuel combustion, phosphate fertilizer and battery industries. [9][10][11] Therefore, it is urgent and essential to develop a sensitive and rapid method for monitoring Cd 2+ levels in water environments and biological systems.…”