A Phase II Trial of Human Secretin Infusion for Refractory Type B Pain in Chronic Pancreatitis

Levenick, John M.; Purich, Edward D.; Gordon, Stuart R.; Gardner, Timothy B.

doi:10.1097/mpa.0b013e318273f3ec

Pancreas

2013

DOI: 10.1097/mpa.0b013e318273f3ec

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A Phase II Trial of Human Secretin Infusion for Refractory Type B Pain in Chronic Pancreatitis

John M. Levenick¹,

Edward D. Purich²,

Stuart R. Gordon³

et al.

Abstract: In patients, especially women, with refractory type B pain from CP, intravenous sHS administration demonstrated a trend toward improvement in self-reported pain and opiate use at 30 days after infusion, although statistical significance was not achieved (clinicaltrials.gov registration number NCT01265875).

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Novel and Experimental Therapies in Chronic Pancreatitis

Jagannath

Garg

2017

Dig Dis Sci

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Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas. The currently available treatment of CP is aimed at controlling symptoms and managing complications. Unfortunately, no specific treatment is available to halt the progression of the disease process because the pathophysiological perturbations in CP are not well understood. In this review, we discuss various therapeutic targets and investigational agents acting on these targets. Among these, therapies modulating immune cells and those acting on pancreatic stellate cells appear promising and may translate into clinical benefit in near future. However, these experimental therapies are mostly in animal models and they do not recapitulate all aspects of human disease. Still they may be beneficial in developing effective therapeutic modalities to curb inflammation in chronic pancreatitis.

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Novel and Experimental Therapies in Chronic Pancreatitis

Jagannath

Garg

2017

Dig Dis Sci

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Bodnar

2016

Peptides

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