A Phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma

Jatoi, Aminah; Ellison, Neil M.; Burch, Patrick A.; Sloan, Jeff A.; Dakhil, Shaker R.; Novotny, Paul J.; Tan, Winston; Fitch, Tom R.; Rowland, Kendrith M.; Young, Charles Y.F.; Flynn, Patrick J.

doi:10.1002/cncr.11200

Cited by 264 publications

(153 citation statements)

References 14 publications

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“…Only one patient manifested a decline in serum PSA, and no patient manifested a tumor response on radiographic assessment or physical examination. Thus, a limited antineoplastic effect with a maximum response rate of 2% was seen with green tea [24]. Similar results were observed in another clinical trial involving patients with hormone refractory CaP.…”

Section: Green Teasupporting

confidence: 85%

“…A case control study, conducted in southeast China during 2001 to 2002, reported a reduced CaP risk with increasing frequency, duration, and quantity of green tea consumption [23]. In another study, patients with asymptomatic androgen-independent metastatic prostate carcinoma and progressive PSA elevation were evaluated after ingestion of 6 g of green tea per day [24]. Only one patient manifested a decline in serum PSA, and no patient manifested a tumor response on radiographic assessment or physical examination.…”

Section: Green Teamentioning

confidence: 99%

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Dietary agents for chemoprevention of prostate cancer

et al. 2008

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Prostate cancer (CaP) is the leading cause of cancer-related deaths in American men, responsible for over 29,000 deaths in the year 2007. Chemoprevention is a plausible and cost-effective approach to reduce cancer morbidity and mortality through inhibition of precancerous events before the occurrence of clinical disease. Indeed, CaP is an ideal candidate disease for chemopreventive intervention as it is typically diagnosed in the elderly population with a relatively slower rate of growth and progression. The potential of dietary substances to act as chemopreventive agents against CaP is increasingly appreciated. Furhter, epidemiological studies have identified significant correlations between CaP incidence and dietary habits. It is hoped that, combining the knowledge based on agents with targets, we will be able to build an armamentarium of naturally occurring chemopreventive substances that could prevent or slow down the development and progression of CaP. In this review, we have summarized the findings from clinical and preclinical studies on dietary agents including green tea, pomegranate, lupeol, fisetin and delphinidin that are currently being investigated in our laboratory for their chemopreventive potential against CaP.

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Section: Green Teasupporting

confidence: 85%

Section: Green Teamentioning

confidence: 99%

Dietary agents for chemoprevention of prostate cancer

et al. 2008

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“…In subsequent studies, Jatoi et al [177] and Luo et al [178] have described an antineoplastic activity in terms of biomarkers: diminished PSA levels [177] and decreased urinary 8-hydroxydeoxyguanosine [178] in patients with prostate and hepatic cancer, respectively. In these trials, patients with prostate cancer received 6 g of green tea per day in six divided doses [177], and four capsules daily containing either 500 or 1000 mg of green tea polyphenols were administrated to the patients with liver cancer [178].…”

Section: Polyphenols and Clinical Trialsmentioning

confidence: 99%

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Ramos¹

2008

Molecular Nutrition Food Res

621

499

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Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary polyphenols have become not only important potential chemopreventive, but also therapeutic, natural agents. Polyphenols have been reported to interfere at the initiation, promotion and progression of cancer. They might lead to the modulation of proteins in diverse pathways and require the integration of different signals for the final chemopreventive or therapeutic effect. Polyphenols have been demonstrated to act on multiple key elements in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis; however, these molecular mechanisms of action are not completely characterized and many features remain to be elucidated. The aim of this review is to provide insights into the molecular basis of potential chemopreventive and therapeutic activities of dietary polyphenols with emphasis in their ability to control intracellular signalling cascades considered as relevant targets in a cancer preventive approach.

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“…demonstrated that green tea extracts (GTE) are more effective when feeding (0.1% in drinking water) is started at very early stages of PCa development (presence of "in situ" histological lesions) while the chemopreventive potential decreases in animals bearing tumors of more advanced stage, finally resulting largely ineffective in animals that display moderately differentiated adenocarcinoma and occasionally metastasis [143]. To reinforce the concept that GTCs are ineffective as chemotherapeutic molecules, very limited or no effects have been observed in patients with advanced PCa [144][145][146]. At difference, we introduced for first the "Proof of Concept" that secondary chemoprevention of PCa with GTCs is feasible [17].…”

Section: Gtcs In Human Pca Chemoprevention: From Epidemiological Datamentioning

confidence: 99%

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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Green Tea Catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human Prostate Cancer (PCa) chemoprevention.In the last decades many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets including, cell surface receptors, lipid rafts and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentration that cannot be achieved in vivo.Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs bioavailability through still poor understood mechanisms. Recent efforts to develop delivery systems that increase GTCs overall bioavailability, by mean of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.

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A Phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma

Cited by 264 publications

References 14 publications

Dietary agents for chemoprevention of prostate cancer

Dietary agents for chemoprevention of prostate cancer

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

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