A Phase II study of St. John's Wort for smoking cessation

Lawvere, Silvana; Mahoney, Martin C.; Cummings, K. Michael; Kepner, James L.; Hyland, Andrew; Lawrence, David; Murphy, Jill M.

doi:10.1016/j.ctim.2006.01.007

Cited by 34 publications

(27 citation statements)

References 34 publications

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“…[5] Although hypericin is a monoamine oxidase inhibitor at high dosages, these effects have not been demonstrated when SJW is consumed at dosages recommended for the treatment of depression. [6,7] Regardless, cases of serotonin syndrome have been reported when SJW was consumed concurrently with SSRIs and caution should be exercised. [8][9][10] More recent studies identified that hyperforin (C 35 H 52 O 4 ) may be another main constituent of SJW hypericum.…”

Section: St John's Wortmentioning

confidence: 95%

Natural remedies for anxiety disorders: potential use and clinical applications

2009

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Section: St John's Wortmentioning

confidence: 95%

Natural remedies for anxiety disorders: potential use and clinical applications

2009

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“…In an open-label study with 37 cigarette smokers who received 900 mg/day of SJW for 3 months, the point prevalence of smoking cessation rate at 3 months was 24% (9/37). 9 Despite …”

Section: Discussionmentioning

confidence: 99%

“…Prior studies with SJW for smoking cessation contained differing amounts of the active ingredient. 9,28 The present study used a dose of SJW with 0.3% hypericin. Different concentrations of the medication across different studies may influence the efficacy.…”

Section: Trial Of St John's Wort For Smoking Cessationmentioning

confidence: 99%

“…Overall, the treatment was well tolerated with no significant adverse effects noted. 8,9 In order to further explore the efficacy of SJW for smoking cessation, we conducted a randomized, blinded, placebocontrolled, three-arm, parallel group, dose-ranging clinical trial. We sought to obtain preliminary data on the efficacy of Mayo Clinic College of Medicine, Rochester, MN.…”

mentioning

confidence: 99%

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A Randomized Clinical Trial of St. John's Wort for Smoking Cessation

Sood

Ebbert

Prasad

et al. 2010

The Journal of Alternative and Complementary Medicine

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Introduction: St. John's wort (SJW) is a widely used herbal supplement. The predominant mechanism(s) accounting for the activity of SJW in vivo are, however, unclear. The purpose of this study was to investigate the efficacy of SJW for smoking cessation. Methods: We conducted a randomized, blinded, placebo-controlled, three-arm, dose-ranging clinical trial. A total of 118 subjects were randomly allocated to receive SJW 300 mg, 600 mg, or a matching placebo tablet 3 times a day combined with a behavioral intervention for 12 weeks. Self-reported smoking abstinence was biochemically confirmed with expired air carbon monoxide. Results: Mean age of the study participants was 37.6 AE 12.4 years; they smoked an average of 20.0 AE 6.6 cigarettes per day for 20 AE 12.1 years. The study dropout rate was high (43%). By intention-to-treat analysis, no significant differences were observed in abstinence rates at 12 and 24 weeks between SJW dose groups and placebo. SJW did not attenuate withdrawal symptoms among abstinent subjects. Abstinence rates did not differ by study group among subjects who took at least 75% of their study medication. No significant side-effects were noted with SJW. Conclusions: In this randomized trial, SJW did not increase smoking abstinence rates. Our data, in combination with data from other studies, suggest that SJW has little role in the treatment of tobacco dependence.

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“…Gerade in diesem Fall kann zur Behandlung von leichten bis mittelgradigen Depressionen, wie man sie im Klimakterium findet, Johanniskraut (Hypericum) eingesetzt werden. Zahlreiche klinische Studien und eine Meta-Analyse bestätigen die Wirksamkeit [104] .…”

Section: Phytotherapie Im Klimakteriumunclassified

Alternative Therapiemöglichkeiten im Klimakterium

Reinhard-Hennch¹,

Strowitzki²,

Hagens³

2006

Gynäkol Geburtshilfliche Rundsch

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Fragestellung: İbersicht über alternative Therapiemöglichkeiten im Klimakterium. Methoden: Literaturrecherche in Cochrane Library und Medline (1966–2006) nach Stichwörtern, zu naturheilkundlicher Intervention im Klimakterium und in Originalarbeiten oder Reviews, die zusätzlich gefunden wurden. Ergebnisse: Die Gesamtdaten zeigen, dass Cimicifuga, eventuell auch Phytoöstrogene, Hopfen und Salbei klimakterische Beschwerden, insbesondere Hitzewallungen, beeinflussen können. Johanniskraut kann moderate depressive Verstimmungen lindern. Für Phytoöstrogene gibt es Hinweise zur Knochenprotektion und Risikoreduktion von Herzerkrankungen. Zum Einfluss des Lebensstils auf Hitzewallungen gibt es keine eindeutigen Aussagen, Studien belegen eine präventive Wirksamkeit auf Knochen und Herz/Kreislauf. Schlussfolgerung: Lebensstil, Cimicifuga und Phytoöstrogene sind eine Option zur Linderung von Wechseljahresbeschwerden und Prävention chronischer Alterserkrankungen. Phytoöstrogene und Cimicifuga können bei Brustkrebspatientinnen nicht empfohlen werden.

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A Phase II study of St. John's Wort for smoking cessation

Cited by 34 publications

References 34 publications

Natural remedies for anxiety disorders: potential use and clinical applications

Natural remedies for anxiety disorders: potential use and clinical applications

A Randomized Clinical Trial of St. John's Wort for Smoking Cessation

Alternative Therapiemöglichkeiten im Klimakterium

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