A phase II experience evaluating quality of life and survival in linac-based SBRT for prostate cancer

Gantry-Mounted Linear Accelerator–Based Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer

“…Ultimately, we obtained individual patient-level data from 7 single-institution prospective phase II trials of gantry-based prostate SBRT from 2006 to 2017. 5,[8][9][10][11][12][13] The site-specific distribution of patients and their treatment characteristics, including dose and prescription specifications, fractionation schedule, margin expansions, image guidance modalities, and toxicity scoring version are displayed in Table 1. Additional details on specific treatment planning parameters and treatment delivery platforms can be found in Table E1 (available online at https://doi.org/10.1016/j.adro.2019.09.010).…”

“…Data from all 7 trials have been published in some capacity before. Four of the included trials have been previously published with no updated data in the current consortium, 9,10,12,13 although 2 others have been previously published, but the present consortium includes update data from these studies. 8,11 The seventh study contributed patient data to the Kishan et al consortium analysis as well, but the present analysis includes additional patients with prolonged follow-up, and individual patient outcomes from this trial have not been previously reported.…”

Comparison of transperineal ultrasound image guidance technique to transabdominal technique for prostate radiation therapy

“…2 Hypo-fractionated high-dose approaches such as stereotactic body radiation therapy (SBRT) of the prostate are being increasingly employed. [3][4][5][6] Several investigators have evaluated the dosimetric consequences of prostate motion and have advocated for intrafractional tracking [7][8][9][10] when high doses are delivered over a small number of fractions. 10 There are multiple technologies available for motion management of the prostate.…”