Abstract:Abstract:Objectives: The aim of this phase I study is to identify the maximum tolerated dose (MTD) and recommended dose (RD) of CPT-11 in combination with UFT/LV and radiation in patients with locally recurrent rectal cancer. Methods: Patients with histologically proven rectal cancer with local recurrence were eligible for this study. Escalating doses of CPT-11 (30-60 mg/m 2 ) were administered on days 3, 10, 24, and 31. UFT (300 mg/m 2 ) and LV (75 mg/body) were given on days 1-5, 8-12, 22-26, and 29-33. Radi… Show more
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